Smoking and AMH levels in women with normal reproductive history

Dafopoulos, Alexandros; Dafopoulos, Konstantinos; Georgoulias, Panagiotis; Γαλάζιος, Γεώργιος; Limberis, V.; Tsikouras, Panagiotis; Koutlaki, N; Maroulis, Georgios

doi:10.1007/s00404-010-1425-1

Cited by 39 publications

(25 citation statements)

References 30 publications

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“…Although there is evidence that smoking decreases ovarian reserve (21, 43), our study and others have not found a relationship between current smoking and AMH (44, 45). Given the relatively young age of our cohort, it is possible that smoking has less of an impact on ovarian reserve in young women.…”

Section: Discussioncontrasting

confidence: 96%

Novel correlates between antimüllerian hormone and menstrual cycle characteristics in African-American women (23–35 years-old)

Marsh

Bernardi

Steinberg

et al. 2016

Fertility and Sterility

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Objective To characterize normative anti-Müllerian hormone (AMH) levels and ascertain which factors are associated with AMH in a large cohort of reproductive-aged women. Design Cross-sectional study. Setting Study of the Environment, Lifestyle and Fibroids (SELF), a longitudinal study performed by the National Institute of Environmental Health Sciences in conjunction with a major health care provider in Detroit, Michigan. Patients 1,654 African-American women (AAW) aged 23-34 at recruitment. Intervention None Main Outcome Measure Serum AMH measured using an ultrasensitive ELISA. Results The median AMH was 3.18 ng/ml, and there was a significant, but nonlinear, relationship between age and AMH, with levels peaking at age 25. As AMH was not normally distributed, log transformation was performed and used for all analyses. In a multivariable age-adjusted model, body mass index, current use of hormonal contraception, and history of a thyroid condition were inversely associated with AMH, while history of abnormal menstrual bleeding and menstrual cycles longer than 35 days were positively associated with AMH. Conclusions While age is correlated with AMH, it accounts for only a portion of the variation seen. This study adds valuable information to the existing literature on normative AMH levels in young reproductive-aged women. While our findings fill a critical data gap for ovarian reserve in AAW, the insights gained will be of benefit for all women.

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Section: Discussioncontrasting

confidence: 96%

Novel correlates between antimüllerian hormone and menstrual cycle characteristics in African-American women (23–35 years-old)

Marsh

Bernardi

Steinberg

et al. 2016

Fertility and Sterility

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“…The changes of sex hormones caused by smoking were already described in cross-sectional studies including large ones [28][29][30], but as to our knowledge no study was focused on the variability of sex hormone levels. Therefore, these data support the hypothesis that the rate of hormonal changes could be more important than absolute magnitude of changes and could be strongly modified by smoking.…”

Section: Discussionmentioning

confidence: 95%

Menopausal transition enhances the atherogenic risk of smoking in middle aged women

Piťha

Lesná

Sekerkova

et al. 2013

International Journal of Cardiology

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“…Six new studies examining the relationship between smoking and sex hormone levels have been conducted on premenopausal women. Although one study observed no significant differences in sex hormones by smoking status [25], the remaining five studies noted significant differences. Smokers had higher progesterone [26•], higher testosterone [18, 26•], and lower absolute levels and less menstrual phase variation of estrogen [26•, 27].…”

Section: Smoking and Sex Hormonesmentioning

confidence: 99%

Women and Smoking: The Effect of Gender on the Epidemiology, Health Effects, and Cessation of Smoking

2014

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Smoking is still the leading cause of premature morbidity and mortality. This paper examines new research on gender differences and the epidemiology of smoking, smoking-related morbidity and mortality, and factors that affect smoking cessation. The rate of decline in the prevalence of smoking has been slowing, especially among adolescent girls. New research suggests that, compared with men, women may be more susceptible to smoking-related morbidity and mortality. Gender-related barriers to smoking cessation include weight gain, sex hormones, and mood. Furthermore, the sensory aspects of smoking may have more of an effect on smoking treatment for women than for men. We discuss new studies that examine smoking-cessation interventions that may be particularly beneficial for women, including exercise (as an adjunct intervention), very low nicotine content cigarettes, and a variety of pharmacotherapy. Further research is needed to identify and target the gender-specific needs of smokers.

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Smoking and AMH levels in women with normal reproductive history

Abstract: Aging significantly decreases AMH levels in women with normal cycles and normal reproductive history, while smoking does not seem to have significant effects on AMH levels.

Cited by 39 publications

References 30 publications

Novel correlates between antimüllerian hormone and menstrual cycle characteristics in African-American women (23–35 years-old)

Novel correlates between antimüllerian hormone and menstrual cycle characteristics in African-American women (23–35 years-old)

Menopausal transition enhances the atherogenic risk of smoking in middle aged women

Women and Smoking: The Effect of Gender on the Epidemiology, Health Effects, and Cessation of Smoking

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