Smart magnetocaloric coatings for implants: Controlled drug release for targeted delivery

Komlev, Aleksei S.; Gimaev, Radel R.; Zverev, V. I.

doi:10.1016/j.physo.2021.100063

Cited by 16 publications

(10 citation statements)

References 31 publications

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“…All these steps will lead to increased tissue healing speed [ 16 , 17 , 18 ]. It is particularly promising to use localized therapeutic strategies because they have a better bioavailability, and they result in immediate bone healing as opposed to systemic therapies [ 19 , 20 , 21 ]. An effective way to enhance bone healing and regeneration is to administer biologically active compounds that induce messages that influence bone healing in a controlled manner [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advancements in Metallic Drug-Eluting Implants

et al. 2023

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Over the past decade, metallic drug-eluting implants have gained significance in orthopedic and dental applications for controlled drug release, specifically for preventing infection associated with implants. Recent studies showed that metallic implants loaded with drugs were substituted for conventional bare metal implants to achieve sustained and controlled drug release, resulting in a desired local therapeutic concentration. A number of secondary features can be provided by the incorporated active molecules, including the promotion of osteoconduction and angiogenesis, the inhibition of bacterial invasion, and the modulation of host body reaction. This paper reviews recent trends in the development of the metallic drug-eluting implants with various drug delivery systems in the past three years. There are various types of drug-eluting implants that have been developed to meet this purpose, depending on the drug or agents that have been loaded on them. These include anti-inflammatory drugs, antibiotics agents, growth factors, and anti-resorptive drugs.

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Section: Introductionmentioning

confidence: 99%

Recent Advancements in Metallic Drug-Eluting Implants

et al. 2023

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“…Apart from the hyperthermic effect, the prominent magnetocaloric effect in MSM Heuslers is an aspect to be explored as a new mechanism for hyperthermia/hypothermia under biological conditions. The initial reports on this phenomenon have been recently shown in Gd and FeRh. − The principle of the effect is based on the magnetically driven adiabatic phase transformation of the material that gives rise to a temperature change. The magnetically driven temperature change can be transferred into surrounding cells in biological environments.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Shape-Memory Heuslers Turn to Bio: Cytocompatibility of Ni–Mn–Ga Films and Biomedical Perspective

Takhsha,

Furlani,

Panseri

et al. 2023

ACS Appl. Bio Mater.

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Magnetic shape-memory (MSM) Heuslers have attracted great attention in recent years for both caloric and magnetomechanical applications. Thanks to their multifunctional properties, they are also promising for a vast variety of biomedical applications. However, this topic has been rarely investigated so far. In this communication, we present the first report on the absence of cytotoxicity of MSM Heuslers in Ni−Mn−Ga epitaxial thin films and the perspective toward bioapplications. Qualitative and quantitative biological characterizations reveal that Ni−Mn− Ga films can promote the adhesion and proliferation of human fibroblasts without eliciting any cytotoxic effect. Additionally, our findings show that the morphology, composition, microstructure, phase transformation, and magnetic characteristics of the films are well preserved after the biological treatments, making the material a promising candidate for further investigations.

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“…The use of small-sized iron oxide in vivo (a study taking place inside a living organism) diagnostic applications dates to about 60 years ago when iron oxide was used on a microscale to identify the cancerous tumor in the lymph system [8]. These days, MNPs are preferred the non-magnetic materials due to their ease of delivery to the target site, biocompatibility, excellent magnetic, and their most miniature hazardous nature in the human body [9,10]. Considering these unique properties, MNPs have many applications in drug delivery, tissue repair, magnetic hyperthermia, MRI to enhance the contrast of images, and cellular separation [9,[11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…These days, MNPs are preferred the non-magnetic materials due to their ease of delivery to the target site, biocompatibility, excellent magnetic, and their most miniature hazardous nature in the human body [9,10]. Considering these unique properties, MNPs have many applications in drug delivery, tissue repair, magnetic hyperthermia, MRI to enhance the contrast of images, and cellular separation [9,[11][12][13][14][15]. MNPs consist of a metallic core made of materials such as Co, Fe, and Ni.…”

Section: Introductionmentioning

confidence: 99%

“…They possess superparamagnetic properties, low toxicity, and high oxidation resistance compared to other metal oxides. However, the tendency to aggregate and oxidization of MNPs in human vessels can lead to severe problems which can be solved by surface characterization and stabilization [9,10], including coating the surface of iron oxides with stabilizer agents and functionalizing with inorganic compounds [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of smart carriers based on tryptophan-functionalized magnetic nanoparticles and its application in 5-fluorouracil delivery

et al. 2022

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Multifunctional nanocarriers, specifically for tumor targeting and traceable features, have been increasingly considered in cancer therapies. Herein, a novel targeting agent (TA), tryptophan (TRP), was proposed for the synthesis of functionalized (3-aminopropyl) triethoxysilane-iron oxide nanoparticles using two methods, creating a smart drug delivery system (DDS). In one method, two-step, glutaraldehyde (GA) as a linker, bonded TRP and amino-functionalized magnetite, and in the second method, one step, TRP binding was carried out by (3-dimethyl aminopropyl)-N’-ethyl carbodiimide hydrochloride (EDC)/N-hydroxysuccinimide ester. The synthesis yield of the second method was 7% higher than the first method. After synthesizing DDS, 5-fluorouracil (5-FU) was loaded on nanocarriers and was observed TRP functionalized nanoparticles by GA have better loading efficiency, which was 50% greater than the product from the one-step method. A pH-sensitive release profile was also studied for 5-FU/DDS with the release of almost 75% and 50% at pH 5.5 and 7.4, respectively. To analyze the biological aspects of nanocarriers, human breast cancer, MCF-7, and embryonic kidney, HEK293, cell lines were used for cellular uptake and 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assays. In vitro studies confirmed that TRP can act as a TA as its cellular uptake through cancerous cells was 40% greater than normal cells, and the MTT assay confirmed that using DDS can increase and decrease the cell viability of normal cells and cancerous cells, respectively, compared to free drug. Therefore, it was concluded that advanced nano-assembly is a great candidate for breast cancer cell-targeted delivery.

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Smart magnetocaloric coatings for implants: Controlled drug release for targeted delivery

Cited by 16 publications

References 31 publications

Recent Advancements in Metallic Drug-Eluting Implants

Recent Advancements in Metallic Drug-Eluting Implants

Magnetic Shape-Memory Heuslers Turn to Bio: Cytocompatibility of Ni–Mn–Ga Films and Biomedical Perspective

Synthesis of smart carriers based on tryptophan-functionalized magnetic nanoparticles and its application in 5-fluorouracil delivery

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