Smart hydrogels as functional biomimetic systems

Lim, Han Liang; Hwang, Yongsung; Kar, Mrityunjoy; Varghese, Shyni

doi:10.1039/c3bm60288e

Cited by 209 publications

(180 citation statements)

References 165 publications

(181 reference statements)

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“…31 Together with the matched mechanical properties discussed above, biodegradability enables the potential application of the PEUs in soft tissue engineering. 1,[3][4][5] The use of PNIPAm-based hydrogels and its copolymers in biomedical applications are restricted, due to nonbiodegradability and toxicity of PNIPAm in its monomeric form. 4,5,49 In comparison to recently developed PGS-co-PEG block copolymers, 24,27 the PEU hydrogels presented slower degradation kinetics owing to the urethane linkages in the covalently crosslinked network.…”

Section: In Vitro Degradationmentioning

confidence: 99%

“…4,5 Ideally, hydrogels for soft tissue engineering should be structurally stable and flexible to withstand mechanical forces and deformations in demanding in vivo environments. 4,5 Tensile test results of PEU hydrogels indicated that an increase in PEG MWt from 400 to either 1000 or 1450 led to a decrease with statistical significance (p < 0.05) in the tensile Young's modulus and tensile strength as well as a significant increase in the tensile energy at break of the PEU hydrogel. PEU-1450 hydrogels presented the lowest Young's modulus of 0.02 MPa, a tensile strength of 0.07 MPa, and the highest elongation at break of 623% ( Figure 4D).…”

Section: Mechanical Properties Of Peusmentioning

confidence: 99%

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Biomimetic poly(glycerol sebacate)/poly(l-lactic acid) blend scaffolds for adipose tissue engineering

2015

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Article:Frydrych, M., Roman, S., MacNeil, S. et al. (1 more author) (2015) Biomimetic poly(glycerol sebacate)/poly(L-lactic acid) blend scaffolds for adipose tissue engineering. Acta Biomaterialia, 18. 40 -49. ISSN 1742-7061 https://doi.org/10.1016/j.actbio.2015.03.004Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/) eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request.

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Section: In Vitro Degradationmentioning

confidence: 99%

Section: Mechanical Properties Of Peusmentioning

confidence: 99%

Biomimetic poly(glycerol sebacate)/poly(l-lactic acid) blend scaffolds for adipose tissue engineering

2015

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“…31,32 The Together with the matched mechanical properties discussed above, biodegradability enables the potential application of the PEUs in soft tissue engineering. 1,[3][4][5] The use of PNIPAm-based hydrogels and its copolymers in biomedical applications are restricted, due to nonbiodegradability and toxicity of PNIPAm in its monomeric form. 4,5,49 In comparison to recently developed PGS-co-PEG block copolymers, 24,27 the PEU hydrogels presented slower degradation kinetics owing to the urethane linkages in the covalently crosslinked network.…”

Section: In Vitro Degradationmentioning

confidence: 99%

Thermoresponsive, stretchable, biodegradable and biocompatible poly(glycerol sebacate)-based polyurethane hydrogels

et al. 2015

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Article:Frydrych, M., Román, S., Green, N.H. et al. (2 more authors) (2015) Thermoresponsive, stretchable, biodegradable and biocompatible poly(glycerol sebacate)-based polyurethane hydrogels. Polymer Chemistry, 6. 7974 -7987. ISSN 1759-9962 https://doi.org/10.1039/c5py01136a eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. This is an Accepted Manuscript, which has been through the Royal Society of Chemistry peer review process and has been accepted for publication.Accepted Manuscripts are published online shortly after acceptance, before technical editing, formatting and proof reading. Using this free service, authors can make their results available to the community, in citable form, before we publish the edited article. We will replace this Accepted Manuscript with the edited and formatted Advance Article as soon as it is available.

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“…"Nature has truly been an inspiration in designing stimuli-responsive hydrogels with dynamic functions and features," says Varghese, who co-authored a review of current and potential applications 5 . He emphasizes that most of the advances are still at the proof-ofconcept phase, but as an example of the technology already on the market he cites a class of temperature-responsive polymers known as poloxamers, which are moving into drugdelivery uses 6 .…”

Section: Strong and Smart Hydrogelsmentioning

confidence: 99%

Polymers: Secrets from the deep sea

Scott¹

2015

Nature

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Smart hydrogels as functional biomimetic systems

Abstract: This review discusses the principles underlying stimuli-responsive behavior of hydrogels and how these properties contribute to their biomimetic functions and applications.

Cited by 209 publications

References 165 publications

Biomimetic poly(glycerol sebacate)/poly(l-lactic acid) blend scaffolds for adipose tissue engineering

Biomimetic poly(glycerol sebacate)/poly(l-lactic acid) blend scaffolds for adipose tissue engineering

Thermoresponsive, stretchable, biodegradable and biocompatible poly(glycerol sebacate)-based polyurethane hydrogels

Polymers: Secrets from the deep sea

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