Thermoresponsive, stretchable, biodegradable and biocompatible poly(glycerol sebacate)-based polyurethane hydrogels

Abstract

Article:Frydrych, M., Román, S., Green, N.H. et al. (2 more authors) (2015) Thermoresponsive, stretchable, biodegradable and biocompatible poly(glycerol sebacate)-based polyurethane hydrogels. Polymer Chemistry, 6. 7974 -7987. ISSN 1759-9962 https://doi.org/10.1039/c5py01136a eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. This is an Accepted Manuscript, which has been through the Royal Society of Chemistry peer review process and has been accepted for publication.Accepted Manuscripts are published online shortly after acceptance, before technical editing, formatting and proof reading. Using this free service, authors can make their results available to the community, in citable form, before we publish the edited article. We will replace this Accepted Manuscript with the edited and formatted Advance Article as soon as it is available.

Thermoresponsive Polyurethane Bearing Oligo(Ethylene Glycol) as Side Chain Without Polyol at Polymer Backbone Achieved Excellent Hydrophilic and Hydrophobic Switching

“…Recently, polyurethane hydrogels have attracted attention as a polymer design to overcome such challenges due to their biodegradability and excellent mechanical properties . Polyurethane hydrogels are designed and synthesized with diisocyanates, and crosslinkers.…”

“…For example, a linear polyurethane composed of alternating hexamethylene diisocyanate (HDI) and various molecular weight PEG ( M n = 600–2,000) exhibited cloud point temperature caused by LCST behavior at 33–38 °C . As for the thermoresponsive polyurethane hydrogels, their swelling and deswelling behaviors between around 10 °C and 50 °C have been reported for several PEG‐based polyurethane hydrogels . However, this PEG‐based polyurethane showed very broad LCST and phase transition, resulting in the slight change of swelling ratios up to about two times.…”

“…[11] Recently, polyurethane hydrogels have attracted attention as a polymer design to overcome such challenges due to their biodegradability and excellent mechanical properties. [12][13][14] Poly urethane hydrogels are designed and synthesized with www.advancedsciencenews.com www.mrc-journal.de without a polyol at polymer backbone bearing OEG as the side chain so as to be soluble in water.…”

“…[15] As for the thermoresponsive polyurethane hydrogels, their swelling and deswelling behaviors between around 10 °C and 50 °C have been reported for several PEG-based poly urethane hydrogels. [12,13] However, this PEG-based poly urethane showed very broad LCST and phase transition, resulting in the slight change of swelling ratios up to about two times. In other words, the hydrophilic and hydrophobic switching ability of the conventional polyurethane is still lower than that of the typical thermoresponsive polymers such as PNIPAM and POEGMA.…”

A skin-like stretchable colorimetric temperature sensor

“…5b, pure PDMS film possessed a tensile Young's modulus, ultimate tensile strength and elongation at break of 1 MPa, 1.8 MPa and 150%, respectively. By comparison, the blue-phase PDA could sustain up to~300% stretch- [41], double network gel (DN gel) [42], poly(N-acryloyl glycinamide) gel (PNAGA gel) [43], polyurethane (PEU gel) [44], polypyrrole-grafted chitosan gel (DCh-Ppy gel) [45], nanocomposite hydrogels (NC gel) [46], hydrophobic association hydrogels (HA gel) [47], bacterial cellulose gel (BC gel) [48] and skin [49][50][51].…”