Biomimetic poly(glycerol sebacate)/poly(l-lactic acid) blend scaffolds for adipose tissue engineering

Abstract

Article:Frydrych, M., Roman, S., MacNeil, S. et al. (1 more author) (2015) Biomimetic poly(glycerol sebacate)/poly(L-lactic acid) blend scaffolds for adipose tissue engineering. Acta Biomaterialia, 18. 40 -49. ISSN 1742-7061 https://doi.org/10.1016/j.actbio.2015.03.004Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/) eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request.

Synthesis, Characterization and 3D Micro-Structuring via 2-Photon Polymerization of Poly(glycerol sebacate)-Methacrylate–An Elastomeric Degradable Polymer

“…Polydispersity increased from 2.4 to 5.2, as reaction lengths increased. These results were comparable to other studies where PGS prepolymer was synthesized using a 1:1 molar ratio of glycerol and sebacic acid [1,16,17,19,23,26]. This ratio favors polymer chain extension over chain branching as reaction duration increases, due to the increased reactivity of the two primary hydroxyl groups of the glycerol monomer compared to its secondary hydroxyl group [27].…”

“…PGS is simple to produce as a soluble prepolymer, through a polycondensation reaction. However, to crosslink PGS into an insoluble matrix requires the application of high temperatures (typically >110 • C) and vacuum to thermally cure the polymer [1,4,[16][17][18][19]. These conditions make the creation of accurate geometries difficult and prevent the use of the polymer in directly incorporating cells or temperature sensitive molecules.…”

Thermoresponsive, stretchable, biodegradable and biocompatible poly(glycerol sebacate)-based polyurethane hydrogels

“…The higher MWt PEGs showed faster degradation over the 31 days studied and this was only slightly enhanced in the presence of the enzyme (which catalyses the hydrolysis of the ester bonds of the PGS segments). 31,32 The Together with the matched mechanical properties discussed above, biodegradability enables the potential application of the PEUs in soft tissue engineering. 1,[3][4][5] The use of PNIPAm-based hydrogels and its copolymers in biomedical applications are restricted, due to nonbiodegradability and toxicity of PNIPAm in its monomeric form.…”

Strategies for Bioengineered Scaffolds that Support Adipose Stem Cells in Regenerative Therapies

“…The blending of poly(glycerol sebacate) (PGS), a biodegradable and biocompatible synthetic elastomer specifically designed to imitate the mechanical behavior of soft tissue, with PLA (to overcome the quality and flexibility concerns of using PGS alone) has shown promise. Frydrych et al showed that ASCs seeded onto the surface of a PGS/PLA scaffold exhibited significant amounts of cellular penetration and substantial collagen accumulation over 21 days [79]. However, in vitro degradation assays determined that degradation appeared to progress too rapidly (50% loss after ~30 days) for this scaffold to support the growth of target tissue, a phenomenon also observed by Patrick et al [77].…”