Smart Homopolymer Modification to Single Glass Conical Nanopore Channels: Dual‐Stimuli‐Actuated Highly Efficient Ion Gating

Abstract

For the first time, the integration of a smart homopolymer poly[2(dimethylamino) ethyl methacrylate] (PDMAEMA), which undergoes both pH- and temperature-induced conformational transitions, is demonstrated in a single glass conical nanopore channel, to achieve a smart nanodevice that can be reversibly switched between the high conducting "on" state and low conducting "off " state with high gating efficiency due to the conformational changes of the homopolymer brush effected by varying the pH and temperature of the surrounding media.National Natural Science Foundation of China[20975084, 20575055, J1030415]; National Basic Research Program of China (973Program)[2007CB935600]; Science and Technology Program of Fujian Province[2009Y0046

Resistive-pulse and rectification sensing with glass and carbon nanopipettes

“…The pH and temperature gated nanopore sensors were prepared by attaching 'smart' homopolymer poly [2-(dimethylamino) ethyl methacrylate] to the inner wall of the conical nanochannel [78]. The pK a of the polymer coating was about 7.0-7.5, and the sign and density of the surface charge could be changed by varying the solution pH and, thus, influencing the rectifying behaviour of the pipette.…”

A single glass conical nanopore channel modified with 6-carboxymethyl-chitosan to study the binding of bovine serum albumin due to hydrophobic and hydrophilic interactions

“…Therefore the ionic rectified characteristics will be mainly determined by the surface chemical properties of the nanopore. Up to now, the rectification phenomenon of the conical nanopore has been widely utilized in the research of such fields like biosensing [10][11][12][13], molecular separation [4,14], and mimicry of biological channels [15,16].…”

“…Only a few of these nanosensors are based on glass materials nanopore channel [13,19,28]. Compared with polymer nanopores, glass conical nanopore channel possesses several advantages include facile and inexpensive preparation, compactness, and superb mechanical robustness [16].…”

Propagation of Concentration Polarization Affecting Ions Transport in Branching Nanochannel Array

“…Such a non-biological rectifying phenomenon was observed in 1997 by Bard in a conically shaped quartz nanopipet. 26 Since then, various ICRs based on cylindrical, [27][28][29][30][31] conical, [32][33][34][35][36][37][38][39][40][41][42] double conical, 43 cigar 44 nanopores and nanochannels have been proposed. However, all these devices are composed of single nanopore or nanochannel with asymmetric geometry.…”