Small polydisperse low density lipoproteins in familial hyperalphalipoproteinemia with complete deficiency of cholesteryl ester transfer activity

Yamashita, Shizuya; Matsuzawa, Yūji; Okazaki, Mitsuyo; Kako, Hiroyuki; Yasugi, Tadao; Akioka, Hisashi; Hirano, Kazuko; Tarui, Seiichiro

doi:10.1016/0021-9150(88)90094-9

Cited by 117 publications

(47 citation statements)

References 20 publications

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“…21 In addition, IR decreases lipoprotein lipase activity, resulting in a delayed clearance of TG-rich lipoproteins. 22 It is generally believed that a delayed clearance of TG-rich lipoprotein is associated with the generation of small dense LDL and lower concentrations of HDL-C. 23,24 IR was significantly correlated with TG, apoB, HDL-C, and LDL size in our school children. Taken together, these findings suggest that IR may play an important role in lipid metabolism even in school children.…”

Section: Discussionmentioning

confidence: 66%

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Relationship Between Lipid Abnormalities and Insulin Resistance in Japanese School Children

Asato

Katsuren

Ohshiro

et al. 2006

ATVB

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Objective-Dyslipidemia and insulin resistance (IR) are risk factors for coronary heart disease (CHD) in adults. To help prevent the development of CHD, it may be useful to understand the relationship between lipid abnormalities and IR during childhood. Methods and Results-IR was assessed by the homeostasis model approximation index. We studied 1175 Japanese school children (642 boys and 533 girls), aged between 7 and 12 years. Obesity was defined by the body mass index standard deviation score (BMISD) (obese: BMISD Ն2.0). BMISD was most significantly associated with IR in nonobese children (Pϭ0.000). Associations of IR with lipid-related parameters were affected by BMISD. After being corrected by BMISD, in nonobese children, log triglycerides (TG), apoB and low-density lipoprotein (LDL) size in boys and log TG, LDL size, and high-density lipoprotein (HDL) cholesterol in girls were still significantly associated with IR (Pϭ0.000 to 0.017). In obese children, all parameters except for LDL cholesterol in boys and LDL size in girls were significantly associated with IR (Pϭ0.000 to 0.030). Multiple regression analysis showed that log TG and LDL size in nonobese children, log TG in obese boys and LDL size in obese girls were independently associated with IR. Children with IIb and IV hyperlipidemia had significantly higher IR than those with normolipidemia and IIa, even after correcting for BMISD and age. Conclusion-Our results suggest that in addition to controlling body weight, it may be important for school children to characterize lipid phenotypes to prevent progression to CHD and/or type 2 diabetes and to identify subjects who are at high risk for these disorders.

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Section: Discussionmentioning

confidence: 66%

“…As mentioned, IR itself can induce hypertriglyceridemia and make LDL size smaller. [21][22][23][24] A substantial reduction of serum TG levels with fibrate treatment did not improve IR. 29,30 Improvement of IR reduced small dense LDL particles.…”

Section: Obesementioning

confidence: 95%

Relationship Between Lipid Abnormalities and Insulin Resistance in Japanese School Children

Asato

Katsuren

Ohshiro

et al. 2006

ATVB

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“…Endotoxin thus appears to have an effect on CETP that is independent of the hypertriglyceridemic effect and potentially serves to prevent or blunt the decrease in HDL cholesterol levels. That decreasing CETP levels may increase HDL cholesterol levels is suggested by an inverse relationship between plasma CETP levels and HDL cholesterol levels in CETP-deficient humans (35,36). In addition, overexpression of CETP in transgenic mice causes decreased HDL cholesterol levels (37,38), and cholesterol feeding of hamsters which increases CETP activity is associated with decreased HDL cholesterol levels (20).…”

Section: Discussionmentioning

confidence: 99%

Endotoxin and cytokines decrease serum levels and extra hepatic protein and mRNA levels of cholesteryl ester transfer protein in syrian hamsters.

Harðardóttir¹,

Moser²,

Fuller³

et al. 1996

J. Clin. Invest.

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Endotoxin alters the metabolism of lipoproteins, including that of high density lipoprotein (HDL). Cholesteryl ester transfer protein (CETP) facilitates exchange of HDL cholesterol for very low density lipoprotein (VLDL) triglyceride, leading to catabolism of HDL. We investigated the effects of endotoxin and cytokines on CETP in Syrian hamsters. Endotoxin induced a rapid and progressive decrease in serum CETP levels; by 48 h CETP had decreased to Ͻ 20% of control levels. Endotoxin also decreased CETP mRNA and protein levels in adipose tissue, heart, and muscle, the tissues with highest levels of CETP mRNA, providing a plausible mechanism for the endotoxin-

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“…22 On the other hand, the results of the present study are consistent with observations made in plasma from CETPdeficient patients. 19 - 21 Indeed, native gradient gel electrophoresis of LDL from homozygotes with virtually no CETP activity revealed an abnormally polydisperse LDL pattern, with some bands larger and others smaller than normal LDL. 20 The origin of the heterogeneity of LDL is still not fully understood.…”

mentioning

confidence: 99%

“…More recently, it has been suggested that CETP could also influence the LDL distribution profile. 19 " 22 Indeed, native gradient gel electrophoresis revealed an abnormal speciation of LDL subclasses in CETP-deficient patients compared with normal control subjects. 20 - 21 In vitro studies confirmed that lipid transfers from HDL to LDL might be a process of intravascular LDL remodeling.…”

mentioning

confidence: 99%

Influence of plasma cholesteryl ester transfer activity on the LDL and HDL distribution profiles in normolipidemic subjects.

Lagrost¹,

Gandjini²,

Athias³

et al. 1993

Arterioscler Thromb

114

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The relations of cholesteryl ester transfer protein (CETP) activity to the distribution of low density lipoproteins (LDLs) and high density lipoproteins (HDLs) were investigated in fasting plasma samples from 27 normolipidemic subjects. LDL and HDL subtractions were separated by electrophoresis on 20-160 g/L and 40-300 g/L polyacrylamide gradient gels, respectively. Subjects were subdivided into two groups according to their LDL pattern. Monodisperse patterns were characterized by the presence of a single LDL band, whereas polydisperse patterns were characterized by the presence of several LDL bands of different sizes. To investigate the influence of lipid transfers on LDL patterns, total plasma was incubated at 37°C in the absence of lecithin: cholesterol acyltransferase (LCAT) activity. The incubation induced a progressive transformation of polydisperse patterns into monodisperse patterns. Under the same conditions, initially monodisperse patterns remained unchanged. Measurements of the rate of radiolabeled cholesteryl esters transferred from HDL 3 s to very low density lipoproteins (VLDLs) and LDLs revealed that subjects with a monodisperse LDL pattern presented a significantly higher plasma CETP activity than subjects with a polydisperse LDL pattern (301±85%/hr per milliliter versus 216±47%/hr per milliliter, respectively; p<0.02). In addition, when total plasma was incubated for 24 hours at 37°C in the absence of LCAT activity, the relative mass of cholesteryl esters transferred from

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Small polydisperse low density lipoproteins in familial hyperalphalipoproteinemia with complete deficiency of cholesteryl ester transfer activity

Cited by 117 publications

References 20 publications

Relationship Between Lipid Abnormalities and Insulin Resistance in Japanese School Children

Relationship Between Lipid Abnormalities and Insulin Resistance in Japanese School Children

Endotoxin and cytokines decrease serum levels and extra hepatic protein and mRNA levels of cholesteryl ester transfer protein in syrian hamsters.

Influence of plasma cholesteryl ester transfer activity on the LDL and HDL distribution profiles in normolipidemic subjects.

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