Small-molecule fluorescent probes for H2S detection: Advances and perspectives

Li, Haonan; Fang, Yuxi; Yan, Junjie; Ren, Xiangyu; Zheng, Chao; Wu, Bo; Wang, Siyuan; Li, Zhan‐Lin; Hua, Hui‐Ming; Wang, Peng; Li, Dahong

doi:10.1016/j.trac.2020.116117

Cited by 93 publications

(45 citation statements)

References 190 publications

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“…ity and response time of detection, fluorescent probes with superior advantages for monitoring H 2 S in real time have been widely investigated. [337][338][339][340][341][342][343][344][345][346][347][348][349][350] However, the applications for in vivo H 2 S detection are severely limited because of the low tissue penetration and spatial resolution, as well as the poor photostability. Thus, other advanced imaging techniques for superior H 2 S detection have been developed, such as NIR-I/II, PA, MR, and PET imaging, allowing for early detection and diagnosis of diseases, realtime observation of biological processes during targeted delivery, cellular uptake, and biodistribution of therapeutics in a detailed manner (Table 3).…”

Section: Bioimagingmentioning

confidence: 99%

Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy

Ding

Chang

et al. 2021

Adv Healthcare Materials

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Advances in nanotechnology have enabled the rapid development of stimuli-responsive therapeutic nanomaterials for precision gas therapy. Hydrogen sulfide (H 2 S) is a significant gaseous signaling molecule with intrinsic biochemical properties, which exerts its various physiological effects under both normal and pathological conditions. Various nanomaterials with H 2 S-responsive properties, as new-generation therapeutic agents, are explored to guide therapeutic behaviors in biological milieu. The cross disciplinary of H 2 S is an emerging scientific hotspot that studies the chemical properties, biological mechanisms, and therapeutic effects of H 2 S. This review summarizes the state-of-art research on H 2 S-related nanomedicines. In particular, recent advances in H 2 S therapeutics for cancer, such as H 2 S-mediated gas therapy and H 2 S-related synergistic therapies (combined with chemotherapy, photodynamic therapy, photothermal therapy, and chemodynamic therapy) are highlighted. Versatile imaging techniques for real-time monitoring H 2 S during biological diagnosis are reviewed. Finally, the biosafety issues, current challenges, and potential possibilities in the evolution of H 2 S-based therapy that facilitate clinical translation to patients are discussed.

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Section: Bioimagingmentioning

confidence: 99%

Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy

Ding

Chang

et al. 2021

Adv Healthcare Materials

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“…Numerous H 2 S-responsive fluorescent probes have been developed on the basis of various mechanisms, for example, nucleophilic addition 20 – 22 , copper sulfide precipitation 23 , reduction of azido or nitro group 24 , and thiolysis of dinitrophenyl ether 25 , etc 26 . These probes have been demonstrated substantial advantages for H 2 S detection in biological systems, offering a powerful tool for real-time imaging of H 2 S due to quick response, noninvasiveness, and high sensitivity 27 – 29 . Nevertheless, most of them are technically challenge to apply in vivo due to the shallow tissue penetration, poor spatial resolution, and severe photon scattering.…”

Section: Introductionmentioning

confidence: 99%

A hydrogen sulphide-responsive and depleting nanoplatform for cancer photodynamic therapy

Zhang

Fang

et al. 2022

Nat Commun

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Hydrogen sulfide (H2S) as an important biological gasotransmitter plays a pivotal role in many physiological and pathological processes. The sensitive and quantitative detection of H2S level is therefore crucial for precise diagnosis and prognosis evaluation of various diseases but remains a huge challenge due to the lack of accurate and reliable analytical methods in vivo. In this work, we report a smart, H2S-responsive and depleting nanoplatform (ZNNPs) for quantitative and real-time imaging of endogenous H2S for early diagnosis and treatment of H2S-associated diseases. We show that ZNNPs exhibit unexpected NIR conversion (F1070 → F720) and ratiometric photoacoustic (PA680/PA900) signal responsiveness towards H2S, allowing for sensitive and quantitative visualization of H2S in acute hepatotoxicity, cerebral hemorrhage model as well as colorectal tumors in living mice. ZNNPs@FA simultaneously scavenges the mitochondrial H2S in tumors leading to significant ATP reduction and severe mitochondrial damage, together with the activated photodynamic effect, resulting in efficient suppression of colorectal tumor growth in mice. We believe that this platform may provide a powerful tool for studying the vital impacts of H2S in related diseases.

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“…Among these, fluorescence-based strategies are the most used for in vitro and in vivo applications, allowing for real-time, sensitive, and simple H 2 S detection. [35,36,42] To date, numerous fluorescent H 2 S probes have been developed that rely on different mechanisms, [42] including reduction-based, [43][44][45] nucleophilicity-based, [46,47] and metal sulfide precipitation-based probes. [48,49] These detection modes take advantage of H 2 S's active reducibility, high nucleophilicity, and strong metal coordination, respectively.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity and Selectivity Analysis of Fluorescent Probes for Hydrogen Sulfide Detection

Zhou

Mazur

Liang

et al. 2022

Chemistry An Asian Journal

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Hydrogen sulfide (H 2 S) is a gasotransmitter known to regulate physiological and pathological processes. Abnormal H 2 S levels have been associated with a range of conditions, including Parkinson's and Alzheimer's diseases, cardiovascular and renal diseases, bacterial and viral infections, as well as cancer. Therefore, fast and sensitive H 2 S detection is of significant clinical importance. Fluorescent H 2 S probes hold great potential among the currently developed detection methods because of their high sensitivity, selectiv-ity, and biocompatibility. However, many proposed probes do not provide a gold standard for proper use and selection. Consequently, issues arise when applying the probes in different conditions. Therefore, we systematically evaluated four commercially available probes (WSP-1, WSP-5, CAY, and P3), considering their detection range, sensitivity, selectivity, and performance in different environments. Furthermore, their capacity for endogenous H 2 S imaging in live cells was demonstrated.

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Small-molecule fluorescent probes for H2S detection: Advances and perspectives

Cited by 93 publications

References 190 publications

Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy

Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy

A hydrogen sulphide-responsive and depleting nanoplatform for cancer photodynamic therapy

Sensitivity and Selectivity Analysis of Fluorescent Probes for Hydrogen Sulfide Detection

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