Hydrogen Sulfide: An Emerging Precision Strategy for Gas Therapy

Abstract

Advances in nanotechnology have enabled the rapid development of stimuli-responsive therapeutic nanomaterials for precision gas therapy. Hydrogen sulfide (H 2 S) is a significant gaseous signaling molecule with intrinsic biochemical properties, which exerts its various physiological effects under both normal and pathological conditions. Various nanomaterials with H 2 S-responsive properties, as new-generation therapeutic agents, are explored to guide therapeutic behaviors in biological milieu. The cross disciplinary of H 2 S is an emerging scientific hotspot that studies the chemical properties, biological mechanisms, and therapeutic effects of H 2 S. This review summarizes the state-of-art research on H 2 S-related nanomedicines. In particular, recent advances in H 2 S therapeutics for cancer, such as H 2 S-mediated gas therapy and H 2 S-related synergistic therapies (combined with chemotherapy, photodynamic therapy, photothermal therapy, and chemodynamic therapy) are highlighted. Versatile imaging techniques for real-time monitoring H 2 S during biological diagnosis are reviewed. Finally, the biosafety issues, current challenges, and potential possibilities in the evolution of H 2 S-based therapy that facilitate clinical translation to patients are discussed.

Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications

“…Furthermore, H 2 S is able to promote the angiogenesis, activate the anti-apoptotic pathways and accelerate the cell cycle of cancer cells to facilitate cancer development. The excessive generation of H 2 S has been demonstrated in numerous types of cancer cells, which has also become potential targets in anticancer therapy to develop H 2 S-triggered theranostic nanoagents for the diagnosis and treatment of cancer [ [137] , [138] , [139] , [140] , [141] , [142] ]. However, this strategy is beyond the scope of our review.…”

Luminescent Sensors Based on the Assembly of Coinage Metal Nanoclusters

“…Hydrogen sulfide is a flammable and explosive gaseous pollutant. It also plays a variety of physiological functions under normal and pathological conditions [87]. In 2017, Wang et al synthesized a new nanohybrid using AgNCs and mercapto-modified silica spheres [88].…”

Hydrogen sulfide-releasing polyurethane/gelatin/keratin–TA conjugate mats for wound healing

“…Hydrogen sulfide (H 2 S) plays a critical regulatory role in physiological and pathological processes. 7,8 For wound healing, H 2 S can promote wound angiogenesis, improve the wound healing environment, and regulate the levels of various growth factors. 9 Nevertheless, H 2 S-based therapy in clinics is still restricted due to its gaseous state and short half-life.…”