Small Intestinal Submucosa Aneurysm Sac Embolization for Endoleak Prevention after Abdominal Aortic Aneurysm Endografting: A Pilot Study in Sheep

Tissue-Engineered Extracellular Matrices (ECMs) as Adjuvant Scaffolds for Endovascular Aneurysmal Repair (EVAR)

“…A reliable method that prevents these complications from occurring is an attractive option. (Brown et al 2006, Schoder et al, 2004, Niyyati et al 2005, Yavuz et al 2006 suggest that tissue-engineered extracellular matrix (ECM) scaffolds derived from xenogenic sources may have the potential to overcome limitations that are associated with traditional mechanical solutions.…”

“…It should also be noted that both SIS endografts and bare nitinol stent exhibited eccentric intimal hyperplasia with eventual occlusion of the stented vessel during the follow www.intechopen.com ) 313 up period. A study by Schoder et al also investigated SIS in the setting of EVAR repair (Schoder et al 2004). In this study the SIS scaffold was suspended against the wall of the aorta as illustrated in Fig.…”

“…A detailed analysis of the remodelling response revealed an established endothelium along the distal and proximal regions of the scaffold with poor endothelialisation of its central portion. (Schoder et al, 2004) In 2005 Niyyati et al assessed the potential for SIS as an intrahepatic protocaval shunt. Only one device remained functional in 6 animals after a 14 day experimental time period (Niyyati et al 2005).…”

Experimental Models of Abdominal Aortic Aneurysms: An Overview

“…Endoleak thrombosis was induced in this model resulting in elimination of the endoleak [202]. In a sheep AAA model of endoleak after endograft placement, embolization with embolic material was employed that consisted of compressed dehydrated small intestinal submucosal (SIS) sponge tightly wrapped in a SIS sheet [203]. In a sheep AAA model of endoleak after endograft placement, embolization with embolic material was employed that consisted of compressed dehydrated small intestinal submucosal (SIS) sponge tightly wrapped in a SIS sheet [203].…”

“…In a sheep AAA model of endoleak after endograft placement, embolization with embolic material was employed that consisted of compressed dehydrated small intestinal submucosal (SIS) sponge tightly wrapped in a SIS sheet [203]. The results of this study indicated that SIS sponge is a promising embolization material for occlusion of the residual sac after EVAR [203]. SIS is a non-immunogenic collagen-rich acellular material that plays the role of a resorbable constructive bioscaffold for tissue repair, structurally and functionally similar to the target tissue [204][205][206].…”