Small Intestinal Bacterial Overgrowth in Irritable Bowel Syndrome: Systematic Review and Meta-analysis

Negative Effects on Psychological Health and Quality of Life of Genuine Irritable Bowel Syndrome–type Symptoms in Patients With Inflammatory Bowel Disease

“…Furthermore, one-in-three CD patients had undergone intestinal resection previously and, given that bile acid diarrhea or small intestinal bacterial overgrowth may occur as a result of surgery, 10,11 and that there is overlap between the symptoms of these conditions and those of IBS, 12,13 it is possible that we have overestimated the prevalence of IBS. In addition, gold-standard investigations for IBD activity, including small bowel imaging and ileocolonoscopy were not performed routinely as the study was conducted within usual clinical practice.…”

Enhancing Diagnostic Performance of Symptom-Based Criteria for Irritable Bowel Syndrome by Additional History and Limited Diagnostic Evaluation

“…In addition, the reference standard we used in our analyses included symptom data from the questionnaire, which may have resulted in an overestimation of the accuracy of the Rome III criteria and its modifications, and a negative colonoscopy. There are other conditions that may mimic IBS, such as bile acid diarrhea, small intestinal bacterial overgrowth, or fructose and lactose intolerance, [38][39][40] which are not excluded by a negative colonoscopy. These were not screened for routinely in this study, which was conducted within usual clinical practice.…”

Irritable Bowel Syndrome and Microscopic Colitis: A Systematic Review and Meta-analysis

“…[4][5][6][7] No known structural or anatomical explanation accounts for the pathophysiology of IBS, although several mechanisms have been proposed, including low-grade mucosal inflammation, visceral hypersensitivity, alterations in fecal flora, and bacterial overgrowth. [8][9][10][11] Management guidelines for IBS recommend that a positive diagnosis is made using symptom-based diagnostic criteria, 12,13 in an attempt to minimize fruitless and repeated invasive investigation. The current gold-standard for diagnosing IBS are the Rome III criteria, 1 but their accuracy has only been assessed in one study to date, 14 and their performance in predicting IBS was modest.…”