Negative Effects on Psychological Health and Quality of Life of Genuine Irritable Bowel Syndrome–type Symptoms in Patients With Inflammatory Bowel Disease

Effect of psychological therapy on disease activity, psychological comorbidity, and quality of life in inflammatory bowel disease: a systematic review and meta-analysis

“…Only two studies examined the effect of psychological therapy in active disease. 30,31 However, observational studies in IBD populations demonstrate that often the greatest psychological burden is seen in patients with active disease, or those with quiescent disease with ongoing GI symptoms in the absence of inflammation, 8,10 suggesting it is these subgroups of patients who may benefit most from these types of treatment. Only one RCT performed a subgroup analysis in patients with "functional" symptoms, which met criteria for irritable bowel syndrome, in patients with quiescent disease.…”

“…6,7 In IBD, psychological co-morbidity, including anxiety, depression, somatisation, and perceived stress, is not only associated with active disease, but also ongoing symptoms in the absence of inflammation. [8][9][10][11][12] Although a temporal relationship between the presence of psychological co-morbidity and the onset of IBD activity has been suggested, 13 a causal relationship remains unproven. If this association is genuine, activation of the brain-gut axis, involving autonomic nervous system-mediated catecholamine release and hypothalamicpituitary-adrenal axis secretion of stress hormones, and the GI response to this, may contribute.…”

The relationship between different information sources and disease‐related patient knowledge and anxiety in patients with inflammatory bowel disease

“…Clinical data were collected at this point. This study was published elsewhere and received approval from the local research ethics committee in November 2012 . These participants were sent a single postal invitation to provide additional data via a paper‐based questionnaire for this current study.…”

The influence of the brain–gut axis in inflammatory bowel disease and possible implications for treatment

“…Even among patients with IBD in histological remission, almost one-inthree meet criteria for IBS. 7 Moreover, there appears to be a consistent association between reporting of abdominal pain or IBS-type symptoms and impaired psychological wellbeing, 4,6 and this relationship is durable over time. 9 Psychological disorders, including anxiety and depression, affect more than 30% of patients with IBD.…”

“…Investigating the prevalence and impact of these type of symptoms in patients with IBD has been the subject of multiple recent research efforts. In patients with quiescent disease, it is estimated that around 10% report frequent abdominal pain, 4 and between 11% and 35% report IBS-type symptoms, [5][6][7][8] distinct from ongoing, continuous abdominal pain that is unrelated to defaecation, with a higher prevalence in CD compared with UC. Even among patients with IBD in histological remission, almost one-inthree meet criteria for IBS.…”