Small Choroidal Melanocytic Lesions

Singh, Arun D.; Mokashi, A; Bena, James; Jacques, R; Rundle, Paul; Rennie, I G

doi:10.1016/j.ophtha.2006.01.053

Cited by 59 publications

(10 citation statements)

References 14 publications

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“…Flat choroidal nevi usually are regarded as benign with little malignant potential unless there is demonstrated growth. 22 However, the carcinogenic potential of flat choroidal melanomas seems to differ from their ability to serve as antigenic foci in autoimmune-susceptible individuals. Both of our patients with choroidal nevi (patients 1066 and 3361 in Table 2) had central scotomata, antiretinal antibodies, and severe ERG changes similar to the other patients with MAR.…”

Section: Resultsmentioning

confidence: 99%

Melanoma-Associated Retinopathy

Lu¹

2009

Arch Ophthalmol

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Section: Resultsmentioning

confidence: 99%

Melanoma-Associated Retinopathy

Lu¹

2009

Arch Ophthalmol

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“…There are several reasons for this controversy, but first and foremost there is a lack of any uniformly accepted terminology or diagnostic criteria of small choroidal melanoma [8,9]. The second issue is the lack of a randomized prospective trial to compare prompt treatment with deferred treatment until the diagnosis is confirmed (documented growth) [10].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…In a large cohort of patients, the risk of growth can be estimated according to the presence or absence of associated clinical features [9,11,12]. Nevertheless, in an individual patient, the distinction between small choroidal melanoma and choroidal nevus is not absolute [9,11]. This limitation exists because most of the risk factors predictive of growth, such as the presence of orange pigment and subretinal fluid, indicate secondary effects on adjacent tissues rather than the intrinsic composition of the lesion [9].…”

Section: Discussionmentioning

confidence: 99%

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De novo Evolution of a Small Choroidal Melanoma

Aleksidze

Singh

2014

Ocul Oncol Pathol

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Aim: To report the evolution of a de novo choroidal melanoma. Method: This is a case report of a 22-year-old white male patient who has been undergoing periodic examination for a choroidal ‘freckle' since 10 years of age. Results: In 2007, a fundus photograph of the left eye showed a nondescript area of choroidal hyperpigmentation temporal to the fovea. Progressive growth was observed and, by 2012, the lesion had become well circumscribed and raised. One year later, a 4.5 × 4.5 × 1.5 mm, dome-shaped, pigmented, choroidal mass with subretinal fluid and orange pigmentation was evident. The lesion was classified as a small choroidal melanoma. Six months after plaque radiotherapy, tumor regression with total resolution of the subretinal fluid was documented. Conclusion: The distinction between small choroidal melanoma and choroidal nevus is not absolute; therefore, some choroidal melanomas may initially be mislabeled as choroidal nevi because of their small size until continued growth identifies them to be small choroidal melanomas. In our case, the documented growth of the choroidal lesion on each consecutive visit and its high-risk features strongly suggest that it had been a melanoma from the beginning. To our knowledge, this is only the second documented case of a de novo evolution of a small choroidal melanoma. © 2014 S. Karger AG, Basel

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“…The likelihood of tumour growth is related to the number of such risk factors that are present. The presence of subretinal fluid (SRF) overlying the tumour is a strong predictor of tumour growth [3][4][5] ; however, subtle retinal detachment can be difficult to see ophthalmoscopically. Optical coherence tomography (OCT) has greatly enhanced the detection of retinal pathology [6] .…”

Section: Introductionmentioning

confidence: 99%

Assessment of indeterminate melanocytic choroidal tumours with optical coherence tomography: A cohort study

Garnier¹,

Grange²,

Kodjikian

2012

JBGC

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Background: It is difficult to differentiate large choroidal naevi from small melanomas. The management of patients with such 'indeterminate melanocytic tumours' is controversial. This is because over-treatment of naevi can cause unnecessary visual loss whereas delayed treatment of melanoma may have fatal consequences. Several studies have shown that serous retinal detachment overlying an indeterminate melanocytic choroidal tumour predicts growth of these tumours; however, these studies have mostly been based on ophthalmoscopy. Optical coherence tomography (OCT) facilitates the detection of subtle retinal detachment. It is not known, however, whether minimal retinal detachment is clinically relevant. The aim of our study was to evaluate OCT as a tool for predicting growth of indeterminate melanocytic choroidal tumours.

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Small Choroidal Melanocytic Lesions

Cited by 59 publications

References 14 publications

Melanoma-Associated Retinopathy

Melanoma-Associated Retinopathy

De novo Evolution of a Small Choroidal Melanoma

Assessment of indeterminate melanocytic choroidal tumours with optical coherence tomography: A cohort study

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