Melanoma-Associated Retinopathy

Choroidal Neovascularization and Chorioretinal Atrophy in a Patient With Melanoma-Associated Retinopathy After Ipilimumab/Nivolumab Combination Therapy

“…These atypical fundus findings of MAR were similar to those found in our patient. Although different antiretinal autoantibodies were reported by Roberts et al, 2 antiretinal autoantibodies against a retinal 60 kDa protein, as found in our patient, have previously been reported in MAR by Lu et al 11 As our patient was on a different medication than the case described by Roberts et al, 2 we suspect these chorioretinal lesions may be a class effect of checkpoint inhibitor therapy. The functionally impaired None of the authors has any financial/conflicting interests to disclose.…”

Choroidal Neovascularization and Chorioretinal Atrophy in a Patient With Melanoma-Associated Retinopathy After Ipilimumab/Nivolumab Combination Therapy

“…These atypical fundus findings of MAR were similar to those found in our patient. Although different antiretinal autoantibodies were reported by Roberts et al, 2 antiretinal autoantibodies against a retinal 60 kDa protein, as found in our patient, have previously been reported in MAR by Lu et al 11 As our patient was on a different medication than the case described by Roberts et al, 2 we suspect these chorioretinal lesions may be a class effect of checkpoint inhibitor therapy. The functionally impaired None of the authors has any financial/conflicting interests to disclose.…”

Melanoma-Associated Retinopathy 28 Years After Diagnosis

“…Objective measures of bipolar cell function can be fundamental to making the diagnosis, with on-off responses during electroretinography (ERG) showing a characteristic b-wave depression . This result can be supported by immunohistochemical analysis, indirect immunoassay, and Western blotting for autoantibodies to bipolar cells; however, although these laboratory tests are used in investigative studies, they have not been established as clinically useful.…”

Ocular adverse events associated with immune checkpoint inhibitors: a novel multidisciplinary management algorithm

“…One patient with pre-existing glaucoma experienced ocular IrAE as the only IrAE, occurring after her first dose of pembrolizumab, and this led to treatment discontinuation. Four patients were diagnosed with anterior uveitis, one had intermediate uveitis, one had melanoma-associated retinopathy (MAR) 19 , 20 and one had suspected ocular ischaemic syndrome. 21 All patients had bilateral eye involvement.…”

Choroidal Neovascularization and Chorioretinal Atrophy in a Patient With Melanoma-Associated Retinopathy After Ipilimumab/Nivolumab Combination Therapy

“…These atypical fundus findings of MAR were similar to those found in our patient. Although different antiretinal autoantibodies were reported by Roberts et al, 2 antiretinal autoantibodies against a retinal 60 kDa protein, as found in our patient, have previously been reported in MAR by Lu et al 11 As our patient was on a different medication than the case described by Roberts et al, 2 we suspect these chorioretinal lesions may be a class effect of checkpoint inhibitor therapy. The functionally impaired None of the authors has any financial/conflicting interests to disclose.…”

Melanoma-Associated Retinopathy 28 Years After Diagnosis

“…Objective measures of bipolar cell function can be fundamental to making the diagnosis, with on-off responses during electroretinography (ERG) showing a characteristic b-wave depression . This result can be supported by immunohistochemical analysis, indirect immunoassay, and Western blotting for autoantibodies to bipolar cells; however, although these laboratory tests are used in investigative studies, they have not been established as clinically useful.…”

Ocular adverse events associated with immune checkpoint inhibitors: a novel multidisciplinary management algorithm

“…One patient with pre-existing glaucoma experienced ocular IrAE as the only IrAE, occurring after her first dose of pembrolizumab, and this led to treatment discontinuation. Four patients were diagnosed with anterior uveitis, one had intermediate uveitis, one had melanoma-associated retinopathy (MAR) 19 , 20 and one had suspected ocular ischaemic syndrome. 21 All patients had bilateral eye involvement.…”

Choroidal Neovascularization and Chorioretinal Atrophy in a Patient With Melanoma-Associated Retinopathy After Ipilimumab/Nivolumab Combination Therapy

“…These atypical fundus findings of MAR were similar to those found in our patient. Although different antiretinal autoantibodies were reported by Roberts et al, 2 antiretinal autoantibodies against a retinal 60 kDa protein, as found in our patient, have previously been reported in MAR by Lu et al 11 As our patient was on a different medication than the case described by Roberts et al, 2 we suspect these chorioretinal lesions may be a class effect of checkpoint inhibitor therapy. The functionally impaired None of the authors has any financial/conflicting interests to disclose.…”

Melanoma-Associated Retinopathy 28 Years After Diagnosis

“…Objective measures of bipolar cell function can be fundamental to making the diagnosis, with on-off responses during electroretinography (ERG) showing a characteristic b-wave depression . This result can be supported by immunohistochemical analysis, indirect immunoassay, and Western blotting for autoantibodies to bipolar cells; however, although these laboratory tests are used in investigative studies, they have not been established as clinically useful.…”

Ocular adverse events associated with immune checkpoint inhibitors: a novel multidisciplinary management algorithm

“…One patient with pre-existing glaucoma experienced ocular IrAE as the only IrAE, occurring after her first dose of pembrolizumab, and this led to treatment discontinuation. Four patients were diagnosed with anterior uveitis, one had intermediate uveitis, one had melanoma-associated retinopathy (MAR) 19 , 20 and one had suspected ocular ischaemic syndrome. 21 All patients had bilateral eye involvement.…”