Small Cell Undifferentiated (Neuroendocrine) Carcinoma of the Uterine Cervix

Weed, John C.; Graff, Adam T; Shoup, Brenda; Tawfik, Ossama

doi:10.1016/s1072-7515(03)00120-0

Cited by 65 publications

(53 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, some reports have suggested that the incidence is increasing [16]. This may be attributed to the fact that response rates for many systemic chemotherapies have improved, resulting in clinicians detecting recurrent disease in unforeseen sites [9,10,11].…”

Section: Discussionmentioning

confidence: 99%

Rapid Manifestation of CNS Metastatic Disease in a Cervical Carcinoma Patient: A Case Report

Brown

Epstein²,

Kim

et al. 2007

Oncology

View full text Add to dashboard Cite

Objectives: Brain metastases originating from primary cervical carcinoma are very rare. Despite surgery and adjuvant therapy, patient prognosis is extremely unfavorable. Prior studies have reported that the median time from the primary disease’s diagnosis to development of CNS metastases is approximately 18 months. Case Report: A 60-year-old woman was initially diagnosed and treated for FIGO clinical stage IB2 cervical carcinoma in March 2007. She underwent a radical hysterectomy, bilateral salpingo-oophorectomy and peri-aortic lymphadenectomy. Two weeks later, the patient presented with dysmetria and homonymous hemianopsia, which was related to a large right occipital CNS metastasis. The patient had surgery to resect the brain tumor and then received Gamma Knife stereotactic radiosurgery and chemotherapy. The neurological deficits were resolved and the patient’s disease status has since remained stable, with five months of follow-up. Conclusion: The incidence of brain metastases originating from primary cervical carcinoma is very rare. Furthermore, the occurrence of CNS metastatic disease manifesting itself within a couple weeks following diagnosis of the primary disease is even more unusual. Since the presenting symptoms of CNS metastatic disease are not well characterized and patient prognosis is very poor, oncology physicians should anticipate the presence of this condition in order to provide prompt and comprehensive treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Rapid Manifestation of CNS Metastatic Disease in a Cervical Carcinoma Patient: A Case Report

Brown

Epstein²,

Kim

et al. 2007

Oncology

View full text Add to dashboard Cite

show abstract

“…This tumor type has the worst prognosis and is reported to have an increased incidence of central nervous system metastases differing from other cervical malignancies [9][10][11] . In a recent analysis of the Surveillance Epidemiology and End Results data, it was stated that neuroendocrine tumors of the cervix are extremely aggressive and survival is poor regardless of the stage at diagnosis when compared with squamous cell types [12] .…”

Section: Discussionmentioning

confidence: 99%

High-Grade Neuroendocrine Carcinoma of the Cervix

Baykal

Al²,

Tulunay³

et al. 2005

Gynecol Obstet Invest

View full text Add to dashboard Cite

Neuroendocrine tumor of the uterine cervix is a rare and aggressive malignancy. Despite controversial, multimodal treatment methods, prognosis and treatment outcomes are worst in advanced stages. We report an early-stage case treated with the multimodal approach. The nomenclature proposed for this tumor type in 1997 by the College of American Pathologists still has some points of discussion. As in our case some of the tumors cannot be defined exactly into small or large cell types, and this causes confusion at least for nomenclature purposes. A ‘mixed’ type for this tumor may be appropriate.

show abstract

“…29,30 Similar to small cell lung cancer, cervical small cell carcinoma is difficult to manage and usually follows an aggressive clinical course, with death within a few years after diagnosis. [24][25][26][27][28][29][30][31] Unlike small cell lung cancer, however, the expression of c-kit protein in cervical small cell c-kit in cervical small cell carcinomas HL Wang and DW Lu carcinomas has not been well investigated. In fact, there has been only one study to date that has included two cases of cervical small cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…26 The current study was specifically designed to investigate c-kit protein expression in small cell carcinomas of the uterine cervix, a rare but highly aggressive neoplasm. [27][28][29][30][31] Our results demonstrate that unlike small cell lung cancers, cervical small cell carcinomas did not frequently overexpress this potentially important therapeutic target protein.…”

mentioning

confidence: 84%

“…Although the exact underlying mechanisms remain to be investigated, we hypothesize that this difference may be related to different etiopathogenetic mechanisms involved in these two types of malignancies in spite of their identical morphology. It has been well established that small cell carcinomas of the uterine cervix, usually occurring in younger women around 40 years of age, [27][28][29][30][31][39][40][41] is etiologically associated with high-risk types of human papillomavirus. [39][40][41][42][43][44][45] In contrast, small cell lung cancer is associated with cigarette smoking and usually occurs in older individuals.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Overexpression of c-kit protein is an infrequent event in small cell carcinomas of the uterine cervix

Wang

2004

Modern Pathology

View full text Add to dashboard Cite

Primary small cell carcinomas of the uterine cervix are uncommon but highly aggressive malignancies. The recent observations that c-kit proto-oncogene, a tyrosine kinase, is overexpressed in small cell lung cancers and that advanced c-kit-expressing gastrointestinal stromal tumors were successfully treated with a selective tyrosine kinase inhibitor STI-571 (Gleevec, imatinib mesylate) prompted us to investigate c-kit protein expression in cervical small cell carcinomas. Using a polyclonal antibody against c-kit protein (CD117), our immunohistochemical studies demonstrated a cytoplasmic staining in six of 22 cases (27%) of cervical small cell carcinoma. However, in five of these c-kit-positive cases, the immunoreactivity was focal and/or weak. Only one case (5%) exhibited a strong and diffuse staining pattern comparable to that seen in gastrointestinal stromal tumors. This was in contrast to small cell lung cancers where a positive staining for c-kit was observed in nine of 14 cases (64%) included in the study for comparison. Among them, five (36%) exhibited a strong and diffuse staining pattern. These results indicate that overexpression of c-kit protein is an infrequent event in small cell carcinomas of the uterine cervix. In comparison with small cell lung cancers, the findings presented in this report may reflect the difference in etiopathogenetic mechanisms underlying these two types of small cell carcinomas.

show abstract

Small Cell Undifferentiated (Neuroendocrine) Carcinoma of the Uterine Cervix

Cited by 65 publications

References 23 publications

Rapid Manifestation of CNS Metastatic Disease in a Cervical Carcinoma Patient: A Case Report

Rapid Manifestation of CNS Metastatic Disease in a Cervical Carcinoma Patient: A Case Report

High-Grade Neuroendocrine Carcinoma of the Cervix

Overexpression of c-kit protein is an infrequent event in small cell carcinomas of the uterine cervix

Contact Info

Product

Resources

About