Small Bowel Obstruction Due to Mycosis Fungoides: An Unusual Presentation

Velagapudi, Poonam; Turagam, Mohit K.; Graham, David L.; Uzoaru, Ikechukwu

doi:10.1097/maj.0b013e31821389da

Cited by 13 publications

(8 citation statements)

References 10 publications

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“…Other T‐cell lymphomas that can rarely involve the GI tract and need to be considered in the differential diagnosis of indolent T‐cell LPDs include, T‐cell prolymphocytic leukemia, angioimmunoblastic T‐cell lymphoma, Mycosis fungoides/Sezary syndrome, HTLV‐1 associated adult T‐cell leukemia/lymphoma and peripheral T‐cell lymphoma, NOS . Apart from the cytomorphologic appearance and unique phenotypic features, the pattern of organ involvement (e.g.…”

Section: Indolent Nk‐cell Lpds Of the Gi Tractmentioning

confidence: 99%

Indolent T‐ and NK‐cell lymphoproliferative disorders of the gastrointestinal tract: a review and update

Matnani

Ganapathi

Lewis

et al. 2016

Hematological Oncology

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Primary gastrointestinal (GI) T-and NK-cell lymphomas are usually aggressive neoplasms associated with high morbidity and mortality. Over the past two decades, however, cases of primary GI lymphoproliferative disorders (LPDs) or lymphomas of T-or NK-cell derivation with indolent behavior have been reported. These LPDs are rare and they can be challenging to diagnose as they share clinical and pathological features with both, inflammatory disorders and aggressive T-and NK-cell lymphomas. Primary, indolent clonal T-cell proliferations of the GI tract, which can be CD4+, CD8+ or CD4À CD8À, have been included as a provisional entity in the newly revised World Health Organization (WHO) classification of lymphoid neoplasms and designated 'indolent T-cell LPD of the GI tract'. It is currently unclear whether the indolent NK-cell LPDs represent reactive or neoplastic proliferations. In this review, we describe the clinical, morphologic, immunophenotypic and genetic features of indolent GI T-and NK-cell LPDs and provide guidance in differentiating them from other inflammatory and neoplastic diseases. We believe that greater awareness of these LPDs amongst physicians and the research community will lead to timely and accurate diagnoses, stimulate investigations into the pathogenetic mechanisms underlying different entities thereby enhancing our understanding of disease biology and enable the development of effective therapeutic regimens.

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Section: Indolent Nk‐cell Lpds Of the Gi Tractmentioning

confidence: 99%

Indolent T‐ and NK‐cell lymphoproliferative disorders of the gastrointestinal tract: a review and update

Matnani

Ganapathi

Lewis

et al. 2016

Hematological Oncology

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“…MF can affect, albeit rarely, every section of the GI tract from the mouth to the rectum, but also the biliary tract and pancreas. The involvement of the GI tract in most cases �an��n�to�pi�ly��isplaying�non�sp��i��symptoms.�How�v��,� some reports showed abrupt and fatal complications such as small bowel obstruction (20) and massive haemorrhage from an ulcerated tumor's nodule in the stomach (5). In our case MF had an indolent course for several years until gastric involvement became apparent.…”

Section: Discussionmentioning

confidence: 99%

“…The involvement of the GI tract in most cases can run torpidly displaying non-specific symptoms. However, some reports showed abrupt and fatal complications such as small bowel obstruction ( 20 ) and massive haemorrhage from an ulcerated tumor's nodule in the stomach ( 5 ). In our case MF had an indolent course for several years until gastric involvement became apparent.…”

Section: Discussionmentioning

confidence: 99%

Mycosis fungoides and gastric T‑cell lymphoma: A case report

et al. 2020

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Mycosis fungoides (MF) is a cutaneous malignant lymphoma with an extended clinical course. MF presents in series of dermatological manifestations, beginning with patches and plaques of the skin, and eventually evolving into tumours. Often MF can occur for extended periods without worsening of external symptoms, while the disease advances internally in organs such as lymph nodes, liver, spleen, lung, bone marrow, gastrointestinal tract, pancreas and kidney. The present report presents a clinical case in which gastrointestinal symptomatology�o��a��a��a�t��t��st��matolog� �o��a��a��a�t��t��st��matolog� ��st��matolog� ical manifestation. Immunohistochemical analysis of the skin, along with small bowel biopsies revealed evidence of gastric T��ll�lymp�oma.�To�t��b�st�o��o��knowl��g�,�t��p��s�nt� st��y�is�t��st�to��s��ib��s��a��as��in�t��lit��at��.� Case report A 65 years old woman came along to our observation at Dermatology Department in January 2012, presenting a cuta� neous eruption characterized by the occurrence of multiple an��xt�nsiv��inflammato�y��yt��mato�s�pat��s,�slig�tly� scaly. The main diameter of patches ranged, in average, from 2 cm to more than 10 cm and lesions were primarily located

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“…There have been reports of MF cases throughout the GI tract, including the small intestine (Table 1) [3, 4, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43]. Briefly, there have been 67 cases of GI MF in the reported literature.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Mycosis Fungoides in the Oral Cavity and Small Intestine Complicated by Perforation

et al. 2016

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Extracutaneous involvement in mycosis fungoides (MF) carries a poor prognosis. Oral and gastrointestinal (GI) tract lesions are both rare locations of disease. We describe the clinical findings of one case with oral and GI MF complicated by perforation after systemic antineoplastic treatment, and review the relevant literature. The patient had a 1-year history of MF before development of tongue and palate tumors. He was treated with local electron beam radiation, but re-presented to the hospital after what was found to be small intestine perforation following systemic antineoplastic therapy. The case reveals key insights into the progression and complications of lymphomas with GI tract involvement.

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Small Bowel Obstruction Due to Mycosis Fungoides: An Unusual Presentation

Cited by 13 publications

References 10 publications

Indolent T‐ and NK‐cell lymphoproliferative disorders of the gastrointestinal tract: a review and update

Indolent T‐ and NK‐cell lymphoproliferative disorders of the gastrointestinal tract: a review and update

Mycosis fungoides and gastric T‑cell lymphoma: A case report

A Rare Case of Mycosis Fungoides in the Oral Cavity and Small Intestine Complicated by Perforation

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