Slow release formulations of metribuzin based on alginate-kaolin-linseed oil

Pepperman, Armand B.; Kuan, Jui-Chang W.

doi:10.1016/0168-3659(93)90205-j

Cited by 50 publications

(30 citation statements)

References 9 publications

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“…Several factors affected the release rate including the ratio of oil/metribuzin in the formulation, the temperature of drying the formulation, and aging of the dried formulation. The use of lignin in combination with alginate also produced a granular formulation with reduced release rates [12,13].…”

Section: Introductionmentioning

confidence: 98%

A study towards release dynamics of thiram fungicide from starch–alginate beads to control environmental and health hazards

Singh

Sharma

Gupta

2009

Journal of Hazardous Materials

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Section: Introductionmentioning

confidence: 98%

A study towards release dynamics of thiram fungicide from starch–alginate beads to control environmental and health hazards

Singh

Sharma

Gupta

2009

Journal of Hazardous Materials

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“…It has been regarded as an excellent polysaccharide for drug delivery system due to its good properties such as nontoxicity, immunogenicity, biocompatibility and biodegradability [14][15][16][17]. However, pure alginate has its inherent drawbacks such as poor mechanical strength, uncontrolled degradation and extensive water uptake properties [18,19], which restrict its real applications [20]. It has been reported that amphiphilic alginate derivative modified by introducing the hydrophobic groups into the hydrophilic polysaccharide is not only a good candidate for the formation of nanoparticles, but also an effective way to enhance its affinity to the hydrophobic drug [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of amphiphilic alginate derivatives and electrospinning blend nanofibers: a novel hydrophobic drug carrier

et al. 2015

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As a kind of novel hydrophobic drug carrier materials, the drug-loaded nanofibers were successfully fabricated using amphiphilic alginate derivative (AAD) and poly (vinyl alcohol) (PVA) by electrospinning method. The AAD was synthesized by amide linkage attachment of octylamine onto the carboxylic group of alginate, which was characterized by the means of elemental analysis, FT-IR spectrometer, 1 H NMR spectrometer and fluorescence measurement. Experimental results showed the amidation of alginate was successful, in which the degree of modification was 0.27 and the critical aggregation concentration in 0.15 mol/L aqueous NaCl solution was 0.43 mg/mL. The octyl groups of AAD could effectively make alginate chains flexible and enhance chain entanglements through the hydrophobic interactions between octyl groups. In contrast to sodium alginate (SA)/ PVA blend solutions, AAD/PVA blend solutions showed more excellent electrospinnability. Additionally, the different volume ratios of SA or AAD to PVA played an important role in the formation and morphology of the electrospun blend nanofibers. Although the amidation of alginate could not fundamentally alter the spinnability of alginate, the content of alginate in the blend nanofibers was appropriately increased. The new generated drug-loaded AAD/PVA (20/80) blend nanofibers exhibited relatively continuous and uniform nanofibers with the average diameter of 191.72 nm. Compared to the drug-loaded SA/PVA (20/80) blend nanofibers, the drug-loaded AAD/PVA (20/80) blend nanofibers presented a sustained release performance with the slow release of about 76 % k-cyhalothrin during the initial period of 10 h.

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“…The leaching of pesticides during the preparation of alginate beads has been improved by synthesizing bi-polymeric beads of alginate with other natural polysaccharides. Alginateclay complexes have been used for various pesticides: diquat bromide [7], 2,6-dichlorobenzonitrile [8], carbofuran [9], thiobencarb [10], metribuzin and alachlor [11,12] and diuron [13]. Starch has been incorporated into alginateclay formulations of thiram [14,15].…”

Section: Introductionmentioning

confidence: 99%

Environmentally Friendly Formulations of Trifluralin Based on Alginate Modified Starch

Onyido¹,

Sha’Ato²,

Nnamonu³

2012

JEP

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In line with global efforts towards sustainable agriculture, the use of starch modified with alginate in the preparation of slow release formulations of the herbicide trifluralin was investigated. Trifluralin was encapsulated in starch-alginate beads, and the resulting slow release formulations (SRFs) characterized using scanning electron microscopy (SEM) and Fourier Transform infrared (FTIR) spectroscopy. Herbicide release from the SRFs was studied in water and compared to release of technical grade trifluralin. Three sets of formulations were made by extrusion into 0.25 M calcium chloride solution: starch/alginate (SSTRF), amylose starch/alginate (ASSTRF) and amylose starch/alginate/groundnut oil (ASTRGNO) beads, and the fourth was from gelatinized starch at 75˚C (SSTRF2). The results showed highly porous spherical beads, the amylose/alginate beads bigger and less porous than the starch/alginate beads with diameters of 2.79 ± 0.01 and 2.37 ± 0.01 mm; porosity of 54.67 ± 0.2 and 60.59% ± 0.2% and swelling of 54.09 ± 0.2 and 61.22% ± 0.2%, respectively. All sets of beads exhibited reduced crystallinity of trifluralin. FTIR revealed a shift to lower wavelength of the carbonyl stretching vibrations from 1750 to 1725 cm -1 and a reduction in intensity of the carboxylate peaks of alginate, suggesting interactions between the formulation components that make for good slow release. 96% of technical grade trifluralin (TGTRF) was released into a 50:50 pH 6.5 Buffer/Methanol aqueous medium in 24 hrs. However, for the starch/TRF formulation, SSTRF, only 9.33% herbicide was released after 24 hrs and 34.94% after 672 hrs (28 days). The amylose starch/TRF formulation released 13.61% herbicide in 24 hrs and 46.95% in 672 hrs, a 12% increase in release of TRF over the starch formulation. Encapsulation in starch produced 65% slow release of TRF and gelatinization achieved 84% retardation. Use of amylose starch as matrix caused 53.15% delay and addition of groundnut oil resulted in 80.87% retardation of TRF release. Encapsulation of TRF in starch/alginate beads is a veritable way of reducing negative environmental effects.

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Slow release formulations of metribuzin based on alginate-kaolin-linseed oil

Cited by 50 publications

References 9 publications

A study towards release dynamics of thiram fungicide from starch–alginate beads to control environmental and health hazards

A study towards release dynamics of thiram fungicide from starch–alginate beads to control environmental and health hazards

Synthesis of amphiphilic alginate derivatives and electrospinning blend nanofibers: a novel hydrophobic drug carrier

Environmentally Friendly Formulations of Trifluralin Based on Alginate Modified Starch

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