Synthesis of amphiphilic alginate derivatives and electrospinning blend nanofibers: a novel hydrophobic drug carrier

Abstract

As a kind of novel hydrophobic drug carrier materials, the drug-loaded nanofibers were successfully fabricated using amphiphilic alginate derivative (AAD) and poly (vinyl alcohol) (PVA) by electrospinning method. The AAD was synthesized by amide linkage attachment of octylamine onto the carboxylic group of alginate, which was characterized by the means of elemental analysis, FT-IR spectrometer, 1 H NMR spectrometer and fluorescence measurement. Experimental results showed the amidation of alginate was successful, in which the degree of modification was 0.27 and the critical aggregation concentration in 0.15 mol/L aqueous NaCl solution was 0.43 mg/mL. The octyl groups of AAD could effectively make alginate chains flexible and enhance chain entanglements through the hydrophobic interactions between octyl groups. In contrast to sodium alginate (SA)/ PVA blend solutions, AAD/PVA blend solutions showed more excellent electrospinnability. Additionally, the different volume ratios of SA or AAD to PVA played an important role in the formation and morphology of the electrospun blend nanofibers. Although the amidation of alginate could not fundamentally alter the spinnability of alginate, the content of alginate in the blend nanofibers was appropriately increased. The new generated drug-loaded AAD/PVA (20/80) blend nanofibers exhibited relatively continuous and uniform nanofibers with the average diameter of 191.72 nm. Compared to the drug-loaded SA/PVA (20/80) blend nanofibers, the drug-loaded AAD/PVA (20/80) blend nanofibers presented a sustained release performance with the slow release of about 76 % k-cyhalothrin during the initial period of 10 h.

<p>Hexyl alginate derivative, an amphiphilic innovative buccal film-forming material of promising mechanical and release characteristics for the improvement of repaglinide bioavailability</p>

“…AHAD concentration showed positive effect on tensile strength as indicated by the positive value of its coefficient in the quadratic nonlinear model equation. The far higher value of its coefficient in comparison with other significant factor coefficients is an indication that A has the major significant effect on tensile strength that can be referred to the high elasticity nature of the AHAD as film forming polymer, where the polymer chain flexibility improved due to decreasing carboxyl moieties by hexyl amidation 42Figure 2A shows that the tensile strength was increased from 112.87 to 147.82 g/cm 2 (at least B level) and 101.92 to 137.98 g/cm 2 (at highest B level) when C is hold constant.…”

Synthesis of a benzyl-grafted alginate derivative and its effect on the colloidal stability of nanosized titanium dioxide aqueous suspensions for Pickering emulsions

“…The results indicated that the graing of hydrophobic benzyl groups could destroy the original intramolecular hydrogen bonding of alginate, which could enhance its molecular exibility. [33][34][35] The successful synthesis of BAD was further proved by 1 H NMR. As shown in Fig.…”

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“…Nanofibers are ultrafine solid fibers having very small diameters, they are generally defined as nanostructured materials with a diameter under 1000 nm and typically a lengthto-width ratio greater than 50 1,2,3,4 . Nanofibers are of remarkable interests for a multiplicity of applications due to their worthwhile properties such as high surface area and porosity with small pore sizes 5 .…”