Sleeping Disorders in Early Chronic Kidney Disease

Santo, Rosa Maria De; Bartiromo, Marilú; Cesare, Maria Concetta; Iorio, Biagio Di

doi:10.1016/j.semnephrol.2005.06.014

Cited by 38 publications

(13 citation statements)

References 26 publications

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“…These findings corroborate the results of clinical studies demonstrating that CKD patients experience short and fragmented sleep that is associated with a worse quality of life (9, 44). Our results demonstrating the sleep problems that occurred since the beginning of the disease (CKD30) are consistent with the findings of De Santo and colleagues (14,15), who reported that sleep disorders occur even during the early stages of CKD, when patients do not require therapies such as dialysis or kidney transplantation.…”

Section: Discussionsupporting

confidence: 92%

Sleep pattern in an experimental model of chronic kidney disease

Hirotsu

Tufik²,

Bergamaschi

et al. 2010

American Journal of Physiology-Renal Physiology

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The prevalence of sleep disorders is significantly elevated in chronic kidney disease (CKD) patients. Numerous factors likely contribute to the high prevalence of sleep problems in uremic patients. The objective of this study was to evaluate the long-term sleep pattern changes in uremic rats during disease progression. Sleep recordings of the rats were monitored during light and dark periods that lasted 12 h each. These recordings were performed on days 7, 30, 60, and 90 after CKD induction. Cardiovascular, hormonal, and biochemical changes were evaluated at these same time points in control and uremic rats. CKD progression was reflected by the presence of hypertension and progressive increases in urea, creatinine, and cholesterol levels. We also observed hormonal fluctuations of corticosterone and ACTH, which indicated a potential alteration in the hypothalamic-pituitary-adrenal axis in diseased rats. In addition, rats with CKD demonstrated fragmented sleep with a greater number of arousals and decreased sleep efficiency in the light period during disease progression. In the dark period, there was an initial increase in sleep efficiency in CKD rats, but after 90 days of CKD, these animals slept less compared with the control group. Collectively, these metabolic and cardiovascular changes were associated with the persistent alterations in sleep architecture observed in CKD rats.

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Section: Discussionsupporting

confidence: 92%

Sleep pattern in an experimental model of chronic kidney disease

Hirotsu

Tufik²,

Bergamaschi

et al. 2010

American Journal of Physiology-Renal Physiology

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“…It is very common for hemodialysis patients to have sleep problems 7–10. Many factors in hemodialysis patients, such as blood urea level, creatinine level, parathyroid hormone level, systolic and diastolic blood pressure, and bone pain, increase the prevalence of sleep problems 11, 12. It has been reported that 50%–80% of dialysis patients experience sleep problems, and sleep problems significantly decrease an individual's quality of life 8, 13, 14…”

mentioning

confidence: 99%

Quality of Sleep in Hemodialysis Patients

Tel

Esmek

2007

Dialysis & Transplantation

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Humans have physical, social, emotional, and intellectual needs. Physical and psychological health depends on sufficiently meeting these basic needs. Sleep is a basic physical need. 1,2 Although sleep functions are not clearly understood, it is accepted that sleep is necessary for maintaining health and a state of wellness. 2 Sleep quality is an important concept in clinical practice and sleep-related research. Sleep quality is measured by whether an individual feels energetic, active, and ready to start a new day.Complaints about sleep quality are very common, and poor quality of sleep is an important indicator of many illnesses. 3,4 Defects in sleep quality can disturb emotions, thoughts, and motivation. Individuals with poor quality of sleep show many physical and cognitive symptoms, such as tiredness, exhaustion, difficulty concentrating, decreased pain threshold, loss of appetite, nervousness, anxiety, and depression. [4][5][6] Sleep disorders have a significant effect on mortality and morbidity. 7 For this reason, a complaint of difficulties with sleep is considered a significant health problem that may negatively affect quality of sleep, quality of life, and state of wellness. 1,2 It is very common for hemodialysis patients to have sleep problems. 7-10 Many factors in hemodialysis patients, such as blood urea level, creatinine level, parathyroid hormone level, systolic and diastolic blood pressure, and bone pain, increase the prevalence of sleep problems. 11,12 It has been reported that 50%-80% of dialysis patients experience sleep problems, and sleep problems significantly decrease an individual's quality of life. 8,13,14 Studies have shown that more than 85% of hemodialysis patients have sleep problems serious enough to affect their quality of life. 14,15 Nephrologists and nephrology nurses who work with hemodialysis patients commonly hear patients complain about sleep disorders, and there is increased interest in studying sleep problems. 16,17 The quality of the sleep of hemodialysis patients, who have a high rate of relapse with sleep problems because they have a combination of poor physical health and emotional problems such as anxiety and depression, needs to be evaluated and improved. The purpose of this study was to evaluate the sleep quality in these patients. Methods and MaterialsOne hundred and fifty patients receiving hemodialysis treatment in a university hospital hemodialysis unit participated in this study. Permission to conduct the study was received from the hospital administration. The purpose of the study was explained to the patients, and their informed consent was received. Patients were included in the study if they were older than age 18, were able to read and write, did not have a barrier to communication or a psychological problem, and agreed to participate. Five patients chose not to participate, and were not included in the study. MeasurementsData were collected using a personal information form and the Pittsburgh

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“… 7 Among the physiological risk factors, kidney dysfunction likely leads to an imbalance of various metabolites influencing sleep, which might cause abnormalities in sleep. 8 – 10 …”

Section: Introductionmentioning

confidence: 99%

“… 100 Low levels of iron have been implicated as the primary cause of RLS and is directly linked to CKD and dialysis. 8 , 16 A measurement of serum ferritin provides a definitive diagnosis as it relates to the levels of serum iron and has been implicated in anemia in case of chronic disease. 94 , 95 …”

Section: Introductionmentioning

confidence: 99%

Exploring sleep disorders in patients with chronic kidney disease

Nigam

Camacho

Chang

et al. 2018

NSS

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Kidney disorders have been associated with a variety of sleep-related disorders. Therefore, researchers are placing greater emphasis on finding the role of chronic kidney disease (CKD) in the development of obstructive sleep apnea and restless legs syndrome. Unfortunately, the presence of other sleep-related disorders with CKDs and non-CKDs has not been investigated with the same clinical rigor. Recent studies have revealed that myriad of sleep disorders are associated with CKDs. Furthermore, there are a few non-CKD-related disorders that are associated with sleep disorders. In this narrative review, we provide a balanced view of the spectrum of sleep disorders (as identified in International Classification of Sleep disorders-3) related to different types of renal disorders prominently including but not exclusively limited to CKD.

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Sleeping Disorders in Early Chronic Kidney Disease

Cited by 38 publications

References 26 publications

Sleep pattern in an experimental model of chronic kidney disease

Sleep pattern in an experimental model of chronic kidney disease

Quality of Sleep in Hemodialysis Patients

Exploring sleep disorders in patients with chronic kidney disease

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