Exploring sleep disorders in patients with chronic kidney disease

Abstract

Kidney disorders have been associated with a variety of sleep-related disorders. Therefore, researchers are placing greater emphasis on finding the role of chronic kidney disease (CKD) in the development of obstructive sleep apnea and restless legs syndrome. Unfortunately, the presence of other sleep-related disorders with CKDs and non-CKDs has not been investigated with the same clinical rigor. Recent studies have revealed that myriad of sleep disorders are associated with CKDs. Furthermore, there are a few non-CKD-related disorders that are associated with sleep disorders. In this narrative review, we provide a balanced view of the spectrum of sleep disorders (as identified in International Classification of Sleep disorders-3) related to different types of renal disorders prominently including but not exclusively limited to CKD.

Physical Symptom Cluster Subgroups in Chronic Kidney Disease

“…Significance levels were determined at p ≤ .05. LCA was estimated using Mplus V 8.1 (Muthén & Muthén, 2018); all other analyses were conducted in StataIC 15 (StataCorp., College Station, TX).…”

“…Variable-centered approaches to clustering, which seek to identify relationships among symptoms and quantify the patient's symptom experience, have been employed in patients with ESRD (Amro et al, 2015;Yu, Huang, & Tsai, 2012). Fatigue (Jhamb et al, 2013;Rodrigue et al, 2011), sleep disturbance (Nigam, Camacho, Chang, & Riaz, 2018), depression/anxiety (Assari & Burgard, 2015), pain (Song, Paul, Ward, Gilet, & Hladik, 2018), and gastrointestinal symptoms (Zhang, Bansal, Go, & Hsu, 2015) are among the most common co-occurring symptoms in CKD (Lockwood et al, 2019). Although variable center approaches are useful in examining relationships among homogeneous populations (Conley, 2017), variable-centered approaches to clustering symptoms are complicated by difficulty interpreting symptom clusters due to heterogeneity of symptom response patterns, thereby limiting their clinical utility (Conley, 2017;Lockwood et al, 2019;Ryan et al, 2019).…”

Association of Insomnia in Patients with Chronic Kidney Disease on Maintenance Hemodialysis

“…Many a time, healthcare professionals fail to recognize the kind of sleep disorder unless they know the common sleep-related issues in accordance with chronic kidney disease (CKD) [1]. Various sleep disorders are associated with CKD, which include insomnia, sleep-related breathing disorders, hypoventilation, central sleep apnea, central disorders of hypersomnolence, circadian rhythm sleep-wake disorders, parasomnias, and sleep-related movement disorders [2].…”

Co-Administration of Melatonin Effectively Enhances the Therapeutic Effects of Pioglitazone on Mesenchymal Stem Cells Undergoing Indoxyl Sulfate-Induced Senescence through Modulation of Cellular Prion Protein Expression

“…Deleterious adverse complications related to CKD and the limited feasibility of currently known therapies serve as a motivation to seek a novel, more effective therapeutic strategy for the prevention or delay of renal injury and of the progression to CKD [ 23 , 24 , 25 ]. Previous studies have suggested that patients with CKD experience sleep impairments, such as obstructive sleep apnea and restless leg syndrome, and that progression to CKD or end-stage renal disease (ESRD) may be correlated with the development of various sleep disorders [ 26 , 27 ]. Similarly, our recent study showed that melatonin ( N -acetyl-5-methoxy tryptamine) secreted by the pineal gland reduces MSCs senescence induced by uremic toxins commonly accumulated in patients with CKD, which suggested that it may offer a potential intervention to enhance MSC-derived therapy for the prevention of CKD progression [ 26 , 28 ].…”