Sleep disturbances in progressive supranuclear palsy

Gross, Robert A.; Spehlmann, Rainer; Daniels, James C.

doi:10.1016/0013-4694(78)90337-1

Cited by 56 publications

(12 citation statements)

References 15 publications

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“…In one of the first case series to evaluate sleep architecture in PSP using PSG, all 4 patients had significantly decreased total sleep time and REM sleep, along with a significant increase in the number and duration of nocturnal awakenings. Non‐REM sleep was also abnormal, with decreased spindles and an increase in alpha‐frequency activity throughout sleep . Additional case reports have also reported decreased total sleep time and fragmented sleep with decreased slow wave and REM sleep .…”

Section: Pspmentioning

confidence: 89%

“…Non-REM sleep was also abnormal, with decreased spindles and an increase in alpha-frequency activity throughout sleep. 89 Additional case reports have also reported decreased total sleep time 90 and fragmented sleep with decreased slow wave and REM sleep. 91 A larger case series of 10 patients found a correlation between the severity of the disease and the decrease in total sleep time.…”

Section: Sleep Architecture Changesmentioning

confidence: 96%

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Sleep Disorders in Atypical Parkinsonism

Abbott

Videnović

2014

Movement Disord Clin Pract

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Sleep disorders are commonly seen in atypical parkinsonism, with particular disorders occurring more frequently in specific parkinsonian disorders. Multiple systems atrophy (MSA) is a synucleinopathy often associated with nocturnal stridor which is a serious, but treatable condition highly specific to MSA. In addition, this disorder is strongly associated with rapid eye movement (REM) sleep behavior disorder (RBD), which is also seen in dementia with Lewy bodies (DLB). RBD is far less prevalent in progressive supranuclear palsy (PSP), which is a tauopathy. Insomnia and impaired sleep architecture are the most common sleep abnormalities seen in PSP. Corticobasilar degeneration (CBD) is also a tauopathy, but has far fewer sleep complaints associated with it than PSP. In this manuscript we review the spectrum of sleep dysfunction across the atypical parkinsonian disorders, emphasize the importance of evaluating for sleep disorders in patients with parkinsonian symptoms, and point to sleep characteristics that can provide diagnostic clues to the underlying parkinsonian disorder.

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Section: Pspmentioning

confidence: 89%

Section: Sleep Architecture Changesmentioning

confidence: 96%

Sleep Disorders in Atypical Parkinsonism

Abbott

Videnović

2014

Movement Disord Clin Pract

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“…Shy-Drager syndrome is associated with sleep apnoea syndromes [5] $4 and an increased incidence of rapid eye movement (REM) sleep behaviour disorder [19]. Patients with progressive supranuclear palsy exhibit reduced total sleep time, fragmentation of nocturnal sleep and markedly reduced REM sleep [9].…”

Section: Introductionmentioning

confidence: 99%

Sleep disorder related to Parkinson’s disease

Partinen¹

1997

J Neurol

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“…Reduced, low amplitude, or even absent sleep spindles have been observed in patients with progressive supranuclear palsy (PSP), a degenerative neurological disorder characterized by impaired voluntary gaze, dysarthria, progressive dystonic axial rigidity, postural instability, bradykinesia, pseudobulbar palsy, and subcortical dementia [60][61][62]. EEG patterns of sleep in PSP are similar to those reported in patients with vascular or mass lesions involving the pontine tegmentum bilaterally, like a stroke [63], a mass lesion [64], or a hematoma [65].…”

Section: Neurodegenerative Disordersmentioning

confidence: 99%

Sleep Spindle Deficit in Schizophrenia: Contextualization of Recent Findings

Castelnovo

D’Agostino

Casetta

et al. 2016

Curr Psychiatry Rep

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Sleep spindles are wax and waning brain oscillations at a frequency range of 11-16 Hz, lasting 0.5-2 s, that define non-rapid eye movement sleep stage 2. Over the past few years, several independent studies pointed to a decrease of sleep spindles in schizophrenia. The aim of this review is to contextualize these findings within the growing literature on these oscillations across other neuro-psychiatric disorders. Indeed, spindles reflect the coordinated activity of thalamocortical networks, and their abnormality can be observed in a variety of conditions that disrupt local or global thalamocortical connectivity. Although the broad methodological variability across studies limits the possibility of drawing firm conclusions, impaired spindling activity has been observed in several neurodevelopmental and neurodegenerative disorders. Despite such lack of specificity, schizophrenia remains the only condition with a typical late adolescence to young adulthood onset in which impaired spindling has been consistently reported. Further research is necessary to clearly define the pathogenetic mechanisms that lead to this deficit and the validity of its widespread use as a clinical biomarker.

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Sleep disturbances in progressive supranuclear palsy

Cited by 56 publications

References 15 publications

Sleep Disorders in Atypical Parkinsonism

Sleep Disorders in Atypical Parkinsonism

Sleep disorder related to Parkinson’s disease

Sleep Spindle Deficit in Schizophrenia: Contextualization of Recent Findings

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