Sleep disorder related to Parkinson’s disease

Partinen, M

doi:10.1007/bf03160564

Cited by 88 publications

(59 citation statements)

References 23 publications

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“…Sleep disturbances in PD, which include rapid eye movement behaviors disorder, sleep fragmentation, daytime somnolence, restless legs syndrome, nightmares, and sleep apnea, are estimated to occur in 60-98% of patients with PD [16,34,35,36,37,38,39]. The current analysis demonstrates that targeting only the motor symptoms of PD will not be sufficient to address the myriad NMS, including sleep complaints, described by patients with PD.…”

Section: Discussionmentioning

confidence: 97%

Associations between Severity of Motor Function and Nonmotor Symptoms in Parkinson's Disease: A Post Hoc Analysis of the RECOVER Study

Swick¹,

Friedman

Surmann

et al. 2014

Eur Neurol

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Background: RECOVER (NCT00474058), a double-blind, placebo-controlled trial in patients with Parkinson's disease (PD) and unsatisfactory early-morning motor symptom control, demonstrated significant improvements with rotigotine in early-morning motor function (Unified Parkinson's Disease Rating Scale [UPDRS] III), and nocturnal sleep disturbances (modified Parkinson's Disease Sleep Scale [PDSS-2]), and improvements in nonmotor symptoms (NMS; Non-Motor Symptom Scale [NMSS]). Methods: Post hoc analyses investigated the correlation between motor symptom and NMS severity in PD by evaluating associations between UPDRS III and both NMSS and PDSS-2 scores. Categories were defined for UPDRS III, NMSS, and PDSS-2 total scores; analyses were conducted for the full analysis set (n = 267). Results: There was a trend toward increasing PDSS-2 and NMSS total and domain scores with increasing UPDRS III category at baseline and end of maintenance (EoM). Pearson correlation coefficients between UPDRS III and both NMSS and PDSS-2 total and domain scores were r = 0.12-0.44 (r² = 0.01-0.19) at baseline, r = 0.05-0.38 (r² = 0.00-0.14) at EoM, and r = -0.02-0.36 (r² = 0.00-0.13) for change from baseline to EoM. Conclusion: There was only a small correlation between severity of early-morning motor symptoms and overall burden of NMS and nocturnal sleep disturbances in RECOVER, suggesting that motor symptoms and NMS originate, at least partly, from distinct pathophysiological pathways.

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Section: Discussionmentioning

confidence: 97%

Associations between Severity of Motor Function and Nonmotor Symptoms in Parkinson's Disease: A Post Hoc Analysis of the RECOVER Study

Swick¹,

Friedman

Surmann

et al. 2014

Eur Neurol

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“…People with PD often suffer from sleep disorders, including insomnia, periodic limb movement disorder and REMsleep disorder (7,12), which can cause excessive nighttime movement. The nighttime activity feature tracks the intensity and duration of users' nighttime movements and displays them on the app.…”

Section: Nighttime Activity Trackingmentioning

confidence: 99%

Enabling breakthroughs in Parkinson’s disease with wearable technologies and big data analytics

Cohen¹,

Bataille²,

Martig³

2016

mHealth

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Development of the IoT platform raised a number of engineering considerations, including wearable sensor choice, data management and curation, and algorithm validation. This project has successfully demonstrated proof of concept that IoT platforms, wearable technologies and the data they generate offer exciting possibilities for more robust, reliable, and low-cost research methodologies and patient care strategies.

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“…Dies gilt für Patienten mit M. Parkinson [29] und Patienten nach Schlaganfall, insbesondere aber für Patienten mit Demenz [30], wobei oftmals die Schlafstörung bei dementiellen Erkrankungen weder von den Patienten selbst noch von den Angehöri-gen in ihrem gesamten Ausmass wahrgenommen wird [31]. Die Analyse des Schlaf-EEG bei Demenz zeigt ein über die normalen physiologischen Altersveränderungen hinausgehendes pathologisches Schlaf-EEG-Profil, das neben der meist vorliegenden Schlafkontinuitätsstörung eine Reduktion des REM-Schlafs aufweist, die im Zusammenhang mit dem cholinergen Defizit dieser Patienten zu sehen ist [31,32].…”

Section: Medizinische Neurologische Und Psychiatrische Erkrankungenunclassified

Schlafstörungen im Alter

Thum¹,

Hemmeter-Spernal²,

Hemmeter³

2011

Swiss Arch Neurol Psychiatr

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Sleep disorder related to Parkinson’s disease

Abstract: Sleep disorders occur in 74-98%

Cited by 88 publications

References 23 publications

Associations between Severity of Motor Function and Nonmotor Symptoms in Parkinson's Disease: A Post Hoc Analysis of the RECOVER Study

Associations between Severity of Motor Function and Nonmotor Symptoms in Parkinson's Disease: A Post Hoc Analysis of the RECOVER Study

Enabling breakthroughs in Parkinson’s disease with wearable technologies and big data analytics

Schlafstörungen im Alter

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