Sleep Disorders in Atypical Parkinsonism

Abbott, Sabra M.; Videnović, Aleksandar

doi:10.1002/mdc3.12025

Cited by 45 publications

(26 citation statements)

References 112 publications

(209 reference statements)

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“…A previous study [ 21 ] found that sleep in PSP is more severely impaired than in PD by polysomnography, but no difference in sleep was found by using PD Sleep Scale (PDSS) questionnaire, indicating that PSP patients rate their sleep problems differently from PD patients. The preferential degeneration of the pontine tegmental nuclei in the brainstem, particularly the pedunculopontine tegmental nuclei (PPTg), may explain these findings [ 22 ]. PPTg is thought to be important for the generation of REM sleep, and the connections between the PPTg and the reticular nuclei of the thalamus are important for generating spindles.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Nonmotor Symptoms in Progressive Supranuclear Palsy

Song

Wei

et al. 2016

Parkinson's Disease

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Objectives. To explore the clinical correlates of nonmotor symptoms (NMS) in progressive supranuclear palsy (PSP) and their differences from healthy controls and patients with Parkinson's disease (PD). Methods. Twenty-seven PSP patients, 27 age- and gender-matched healthy controls (HC), and 27 age- and gender-matched PD patients were included for this case-control study. NMS were assessed using the Nonmotor Symptoms Scale (NMSS, including 9 domains). Results. All PSP patients reported NMS. The frequency and severity of “sleep/fatigue,” “mood/apathy,” “attention/memory,” “gastrointestinal,” “sexual dysfunction,” and “miscellaneous” domains in PSP group were significantly higher than those in HC group (P < 0.05). The frequency of “mood/apathy,” “attention/memory,” and “sexual dysfunction” domains and the severity of “attention/memory” and “gastrointestinal” domains in PSP group were significantly higher than those in PD group (P < 0.05). The “attention/memory” domain in PSP had a significant but weak-to-moderate correlation with age (R = 0.387, P = 0.046) and onset age (R = 0.406, P = 0.036). Conclusions. NMS are common in PSP patients. Patients with PSP seem to be subjected to more frequent and severe specific NMS compared to healthy aging subjects and PD patients. Older PSP patients and late-onset patients are likely to be subjected to cognitive decline.

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Section: Discussionmentioning

confidence: 99%

Characteristics of Nonmotor Symptoms in Progressive Supranuclear Palsy

Song

Wei

et al. 2016

Parkinson's Disease

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“…[123] RBD is common in and strongly correlated with alpha-synucleinopathies (SPs), with the prevalence varying by diseases: 30–50% in PD and 80–95% in MSA. [4] In addition, idiopathic RBD is considered a harbinger of neurodegenerative disorders.…”

Section: Introductionmentioning

confidence: 99%

Tonic Electromyogram Density in Multiple System Atrophy with Predominant Parkinsonism and Parkinson's Disease

Wang

Shen

Xiong

et al. 2017

Chinese Medical Journal

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Background:Both Parkinson's disease (PD) and multiple system atrophy (MSA) have associated sleep disorders related to the underlying neurodegenerative pathology. Clinically, MSA with predominant parkinsonism (MSA-P) resembles PD in the manifestation of prominent parkinsonism. Whether the amount of rapid eye movement (REM) sleep without atonia could be a potential marker for differentiating MSA-P from PD has not been thoroughly investigated. This study aimed to examine whether sleep parameters could provide a method for differentiating MSA-P from PD.Methods:This study comprised 24 MSA-P patients and 30 PD patients, and they were of similar age, gender, and REM sleep behavior disorder (RBD) prevalence. All patients underwent clinical evaluation and one night of video-polysomnography recording. The tonic and phasic chin electromyogram (EMG) activity was manually quantified during REM sleep of each patient. We divided both groups in terms of whether they had RBD to make subgroup analysis.Results:No significant difference between MSA-P group and PD group had been found in clinical characteristics and sleep architecture. However, MSA-P patients had higher apnea-hypopnea index (AHI; 1.15 [0.00, 8.73]/h vs. 0.00 [0.00, 0.55]/h, P = 0.024) and higher tonic chin EMG density (34.02 [18.48, 57.18]% vs. 8.40 [3.11, 13.06]%, P < 0.001) as compared to PD patients. Subgroup analysis found that tonic EMG density in MSA + RBD subgroup was higher than that in PD + RBD subgroup (55.04 [26.81, 69.62]% vs. 11.40 [8.51, 20.41]%, P < 0.001). Furthermore, no evidence of any difference in tonic EMG density emerged between PD + RBD and MSA - RBD subgroups (P > 0.05). Both disease duration (P = 0.056) and AHI (P = 0.051) showed no significant differences during subgroup analysis although there was a trend toward longer disease duration in PD + RBD subgroup and higher AHI in MSA - RBD subgroup. Stepwise multiple linear regression analysis identified the presence of MSA-P (β = 0.552, P < 0.001) and RBD (β = 0.433, P < 0.001) as predictors of higher tonic EMG density.Conclusion:Tonic chin EMG density could be a potential marker for differentiating MSA-P from PD.

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“…Neuronal loss was confined to the substantia nigra and locus coeruleus in the brainstem, potentially suggesting these systems, in association with some white matter dysfunction, may play a larger role than appreciated in these symptoms. Such symptoms have also been described by others in the few autopsy-confirmed MSA-P cases with prolonged disease durations [3,5], with REM sleep behaviour disorder strongly associated with MSA [16] and visual hallucinations found in 9% of MSA cases [17]. Cognitive impairment is considered an exclusion criterion for MSA according to the latest consensus statement [9], and the presence of this symptom at the end of a long disease course is considered more indicative of PD.…”

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confidence: 82%