Sleep disorders and cancer: State of the art and future perspectives

Mogavero, Maria Paola; DelRosso, Lourdes M.; Fanfulla, Francesco; Bruni, Oliviero; Ferri, Raffaele

doi:10.1016/j.smrv.2020.101409

Cited by 133 publications

(128 citation statements)

References 109 publications

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“…Sleep problems are among the most frequently reported complaints in cancer patients across all stages of the disease (i.e., before, during, and after treatment) [1,2]. This issue has received research attention in patients with solid tumors but has rarely been investigated in hematological cancer patients [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Sleep problems and their interaction with physical activity and fatigue in hematological cancer patients during onset of high dose chemotherapy

Castelli

Elter

Wolf

et al. 2021

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Purpose Sleep problems reported by hematological cancer patients are usually linked to higher levels of cancer-related fatigue. Although the awareness of sleep problems in solid cancer patients is rising, there has been less attention to the issue in hematological cancer patients. The present study assesses the differences in sleep by comparing physical activity and fatigue levels among hematological cancer patients during the onset of chemotherapy. Furthermore, it investigates the relationship between sleep, physical activity, and fatigue through mediation analysis. Methods The recruited sample consists of 58 newly diagnosed hematological cancer patients (47.1 ± 15.4 yrs; 51.7% males). Subjects completed questionnaires assessing sleep (PSQI), physical activity (visual analogue scale), fatigue (MFI-20), anxiety, depression (HADS), and quality of life (EORTC QLQ-C30) within two weeks from starting treatment. Results The sample reported more sleep problems in comparison to the German population norm. The classification as good (ca 25%) or bad sleepers (ca 75%) showed less frequent physical activity (p = .04), higher fatigue (p = .032), anxiety (p = .003), depression (p = .011) and pain (p = .011) in bad sleepers. The mediation analysis revealed significant indirect effects of sleep on fatigue through physical activity habits. Conclusions This study highlights the combined action of sleep problems and physical activity on fatigue during the onset of induction chemotherapy. These two parameters could represent meaningful intervention targets to improve a patient’s status during chemotherapy. Trial registration The study was registered on the WHO trial register (DRKS00007824).

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Section: Introductionmentioning

confidence: 99%

Sleep problems and their interaction with physical activity and fatigue in hematological cancer patients during onset of high dose chemotherapy

Castelli

Elter

Wolf

et al. 2021

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“…The treatment of cancer lies not only in the disease itself and prolonging survival time, but also in improving quality of life (10,11). Long-term continuous negative emotions will affect the endocrine system, central nervous system, and other functions, causing many undesirable consequences (12,13).…”

Section: Discussionmentioning

confidence: 99%

Effect of individualized psychological intervention on negative emotion and sleep quality of patients after bladder cancer surgery: a randomized controlled trial

Zhang¹,

Han²,

Zhang³

et al. 2021

Transl Androl Urol

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“…In recent years, a series of studies have been conducted on the role of orexins not only in the field of sleep disorders but also in oncology, discovering that modulation of the orexin signaling may also unexpectedly play a therapeutic role in the treatment of some types of cancer [ 120 , 121 ]. One study demonstrated that OXA stimulates neovascularization [ 122 ].…”

Section: Orexin Cancer and Neurodegenerative Diseasesmentioning

confidence: 99%

“…More recent data on human colon cancer cell lines indicate that OXA induces autophagy [ 127 ] and that dual-agonist occupancy of OR1 and cholecystokinin A receptor heterodimers decreases migration [ 128 ]. Orexin-dependent apoptosis might be mediated by two immunoreceptor tyrosine-based inhibitory motifs in both OR1 and OR2, involvement of the phosphotyrosine phosphatase SHP2, and induction of mitochondrial apoptosis [ 120 ].…”

Section: Orexin Cancer and Neurodegenerative Diseasesmentioning

confidence: 99%

Focus on the Complex Interconnection between Cancer, Narcolepsy and Other Neurodegenerative Diseases: A Possible Case of Orexin-Dependent Inverse Comorbidity

Mogavero

Silvani

DelRosso

et al. 2021

Cancers

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Conditions such as Alzheimer’s (AD) and Parkinson’s diseases (PD) are less prevalent in cancer survivors and, overall, cancer is less prevalent in subjects with these neurodegenerative disorders. This seems to suggest that a propensity towards one type of disease may decrease the risk of the other. In addition to epidemiologic data, there is also evidence of a complex biological interconnection, with genes, proteins, and pathways often showing opposite dysregulation in cancer and neurodegenerative diseases. In this narrative review, we focus on the possible role played by orexin signaling, which is altered in patients with narcolepsy type 1 and in those with AD and PD, and which has been linked to β-amyloid brain levels and inflammation in mouse models and to cancer in cell lines. Taken together, these lines of evidence depict a possible case of inverse comorbidity between cancer and neurodegenerative disorders, with a role played by orexins. These considerations suggest a therapeutic potential of orexin modulation in diverse pathologies such as narcolepsy, neurodegenerative disorders, and cancer.

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Sleep disorders and cancer: State of the art and future perspectives

Cited by 133 publications

References 109 publications

Sleep problems and their interaction with physical activity and fatigue in hematological cancer patients during onset of high dose chemotherapy

Sleep problems and their interaction with physical activity and fatigue in hematological cancer patients during onset of high dose chemotherapy

Effect of individualized psychological intervention on negative emotion and sleep quality of patients after bladder cancer surgery: a randomized controlled trial

Focus on the Complex Interconnection between Cancer, Narcolepsy and Other Neurodegenerative Diseases: A Possible Case of Orexin-Dependent Inverse Comorbidity

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