Sleep problems and their interaction with physical activity and fatigue in hematological cancer patients during onset of high dose chemotherapy

Castelli, Lucia; Elter, Thomas; Wolf, Florian; Watson, Matthew; Schenk, Alexander; Steindorf, Karen; Bloch, Wilhelm; Hallek, Michael; Joisten, Niklas; Zimmer, Philipp

doi:10.1007/s00520-021-06377-5

Cited by 18 publications

(10 citation statements)

References 51 publications

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“… 48 Interestingly, Castelli et al highlighted the sleep problems in hematological cancer patients. 50 Our study confirmed this result. In addition, we further found that sleep duration was the independent factor associated with depression and anxiety in patients with leukemia.…”

Section: Discussionsupporting

confidence: 87%

Short Sleep Duration as a Risk Factor for Depression, Anxiety and Fatigue in Patients with Leukemia

Yu¹,

Mujun²,

Liao³

et al. 2022

NDT

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Objective Our study aimed to investigate the level of depression, anxiety, and fatigue in patients with leukemias, and analyze the influence of sleep duration on the mental symptoms of patients with leukemias. Methods A total of 127 patients were enrolled in our study and completed the questionnaire survey. Self-Assessment Depression Scale (SDS), Self-Assessment Anxiety Scale (SAS), and the Fatigue Scale-14 (FS-14) were adopted. The patient’s lifestyle information, including exercise, alcohol abuse, and smoking, was obtained from the patient’s self-report. Results Depression score of patients with sleep duration >8 hours (long duration group) was 56.21±11.63, which was significantly lower than that of patients sleep duration between 6 and 8 hours (medium duration group) with 59.61±8.77 and patients sleep <6 hours (short duration group) with 64.82±6.42 (P = 0.007). Similarly, the anxiety score of long duration group, medium duration group and short duration group was 45.36±11.41, 48.26±6.96 and 53.53±5.87, respectively (P = 0.005). The fatigue score of short duration group is 8.47±2.45, which is higher than others (P = 0.046). To further identify the relationship, we evaluated physical fatigue and mental fatigue levels in patients with or without symptoms of depression. We found that patients with symptoms of depression have a higher score both in physical fatigue and mental fatigue (all p < 0.001). Similar trend was observed in patients with or without symptoms of anxiety (all p < 0.001). However, alzhough patients with leukemia in long duration group have the highest score of physical fatigue (p = 0.016), no significant difference in mental fatigue was found in different sleeping duration group (p = 0.587). Furthermore, multivariate analyses were conducted and revealed that sleep duration was the independent factor associated with depression (OR = 0.270, P = 0.003) and anxiety (OR = 0.473, P = 0.010). Conclusion For leukemia patients with short sleep duration, a prompt evaluation of their level of depression, anxiety, and fatigue and the initiation of timely interventions is essential.

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Section: Discussionsupporting

confidence: 87%

Short Sleep Duration as a Risk Factor for Depression, Anxiety and Fatigue in Patients with Leukemia

Yu¹,

Mujun²,

Liao³

et al. 2022

NDT

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“…In a study of 200 family caregivers, scholars found that less than half of the caregivers were willing to seek professional help on their own problems. Therefore, as a professional helper, social workers should provide services for cancer caregivers to help them out of their predicament [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Study on the Conduction Analysis and Blocking Intervention Scheme of Emotional Disorders between Cancer Patients and Their Families

Zhang

Song

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. To analyze the transmission and blocking intervention scheme of emotional disorders between cancer patients and their families. Methods. About 150 patients with cancer and 150 family members with mood disorders treated in a tertiary hospital in North China from March 2021 to Octobor2021 were enrolled. The patients were randomly assigned into control group and study group. The control group received routine intervention, and the study group received the diagnosis, intervention, and treatment strategies of doctor-patient-affective disorder. The factors related to the transmission of emotional disorders between cancer patients and their families were analyzed, and the alterations of anxiety, depression, social support, and satisfaction of the two groups were compared under different blocking intervention schemes. Results. (1) Univariate analysis indicated that there were significant differences in family age, family income, sex, location of tumor, course of disease, TNM stage, somatic symptoms, and the incidence of anxiety and depression. There exhibited no significant difference between the gender of the family, the years of education of the family, the occupational status of the family, the relationship between the family and the patient, the mode of payment of the patient’s medical expenses, the age of the patient, the mode of treatment of the patient, the degree of knowledge of the disease, and the incidence of anxiety and depression ( P > 0.05 ). The anxiety and depression status of relatives were taken as dependent variables, and the age of family members, family income status, sex of patients, location of tumor, course of disease, TNM stage, and physical symptoms of patients were taken as independent variables, and the data were analyzed by Logistic regression analysis. Logistic regression analysis indicated that family income, tumor location, disease course, TNM stage, and somatic symptoms were the risk factors of anxiety and depression in relatives. (2) Comparison of social support status and intergroup, the objective support, subjective support, support utilization, and total score of social support in the study group were higher compared to the control group. In terms of the depression score before intervention, there exhibited no significant difference ( P > 0.05 ), but after intervention, the depression score of the two groups decreased, and the depression score of the study group was lower compared to the control group before intervention, 1 week, 2 weeks, 3 weeks, and 4 weeks after intervention ( P < 0.05 ). In terms of the anxiety score before intervention, there exhibited no significant difference ( P > 0.05 ), but after intervention, the anxiety score of the two groups decreased, and the anxiety score of the study group was lower compared to the control group before intervention, 1 week, 2 weeks, 3 weeks, and 4 weeks after intervention ( P < 0.05 ). Comparison of the satisfaction between the two groups and the study group was very satisfied in 56 cases, satisfactory in 14 cases, and general in 5 cases, and the satisfaction rate was 100.00%. The control group was very satisfied in 35 cases, satisfactory in 23 cases, general in 12 cases, and dissatisfied in 5 cases, and the satisfaction rate was 93.33%. The satisfaction of the study group was higher compared to the control group ( P < 0.05 ). Conclusion. Family income, tumor location, course of disease, TNM stage, and somatic symptoms are the risk factors of anxiety and depression in relatives. After establishing the diagnosis, intervention and treatment strategies of doctor-patient-affective disorder, the emotional disorder of family members of cancer patients, is significantly promoted, and the intervention satisfaction is high, so the scheme is worth promoting.

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“…The characteristics of nocturnal sleep are fundamental indicators of the quality of life: the quantity and quality of sleep represent essential factors that can positively or negatively influence the individual psycho-physical abilities and health ( Ohayon et al, 2017 ; Castelli et al, 2022 ). Regular and efficient sleep derives from the interaction between homeostatic and circadian processes, determining the so-called sleep-wake circadian rhythm or cycle.…”

Section: Introductionmentioning

confidence: 99%

Sleep and spa therapies: What is the role of balneotherapy associated with exercise? A systematic review

et al. 2022

Self Cite

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Balneotherapy and exercise are potential factors influencing sleep through several physiological pathways and relaxing effects. This review aims to assess whether balneotherapy can improve sleep quality in concomitance or not with exercise. The research was conducted on Medline, Scopus, PubMed, Web of Science, and Cochrane Library databases. The current review followed PRISMA reporting guidelines and involves twenty-one articles grouped into four sections based on the characteristics of the balneotherapy protocol: 1.a Balneotherapy–thermal water immersion alone (five studies); 1.b Balneotherapy–thermal water immersion with other spa treatments (six studies); 2.a Balneotherapy and physical exercise–balneotherapy and out-of-the-pool physical exercise (eight studies); 2.b Balneotherapy and physical exercise–balneotherapy and in-pool physical exercise (three studies). Apart from healthy or sub-healthy subjects, patients recruited in the studies were affected by fibromyalgia, ankylosing spondylitis, osteoarthritis, musculoskeletal pain, subacute supraspinatus tendinopathy, and mental disorders. Duration, number of sessions, and study protocols are very different from each other. Only one study objectively evaluated sleep, whereas the others used subjective sleep assessment methods. Eight studies considered sleep as a primary outcome and ten as secondary. Sixteen out of twenty-one studies described improvements in self-perceived sleep quality. Thus, balneotherapy associated with other spa treatments and physical exercise seems to be effective in improving self-perceived sleep quality. However, the miscellany of treatments makes it difficult to discern the isolated effects of balneotherapy and physical exercise. Future studies should consider using an objective sleep assessment method and describing the pathways and physiological mechanisms that could provoke sleep changes during balneotherapy treatments.

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Sleep problems and their interaction with physical activity and fatigue in hematological cancer patients during onset of high dose chemotherapy

Cited by 18 publications

References 51 publications

Short Sleep Duration as a Risk Factor for Depression, Anxiety and Fatigue in Patients with Leukemia

Short Sleep Duration as a Risk Factor for Depression, Anxiety and Fatigue in Patients with Leukemia

Study on the Conduction Analysis and Blocking Intervention Scheme of Emotional Disorders between Cancer Patients and Their Families

Sleep and spa therapies: What is the role of balneotherapy associated with exercise? A systematic review

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