Sleep Differences Among Children With Autism Spectrum Disorders and Typically Developing Peers

Elrod, Marilisa; Hood, Bradley S.

doi:10.1097/dbp.0000000000000140

Cited by 150 publications

(136 citation statements)

References 62 publications

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“…Our results were in accordance with the findings of a previous meta-analysis in children with ASD,10 in which these children also showed significantly lower total sleep time, increased sleep onset latency and worse sleep efficiency compared with typically developing children. However, these differences between groups observed during PSG were not consistent with actigraphy-defined measures since only sleep time or sleep efficiency statistically differed.…”

Section: Conclusion and Clinical Implicationssupporting

confidence: 92%

“…While a number of individual studies have been conducted, we are aware of only one meta-analysis that summarised the available body of evidence 10. However, this meta-analysis was limited to objective sleep studies, that is, studies relying on actigraphic or polysomnographic measures.…”

Section: Introductionmentioning

confidence: 99%

“…While these (in particular, polysomnography (PSG)) are considered rigorous measures of sleep, it is important to also consider sleep measures subjectively reported by patient and/or their parents via questionnaires, as they are arguably more ‘ecological’ and they reflect the subjective perception, which is important in the management process of the disorder. Furthermore, the meta-analysis by Elrod and Hood10 was published in 2015 and, as such, an update is warranted.…”

Section: Introductionmentioning

confidence: 99%

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Sleep in youth with autism spectrum disorders: systematic review and meta-analysis of subjective and objective studies

Díaz‐Román

Zhang

Delorme

et al. 2018

Evid Based Mental Health

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BackgroundSleep problems are common and impairing in individuals with autism spectrum disorders (ASD). Evidence synthesis including both subjective (ie, measured with questionnaires) and objective (ie, quantified with neurophysiological tools) sleep alterations in youth with ASD is currently lacking.ObjectiveWe conducted a systematic review and meta-analysis of subjective and objective studies sleep studies in youth with ASD.MethodsWe searched the following electronic databases with no language, date or type of document restriction up to 23 May 2018: PubMed, PsycInfo, Embase+Embase Classic, Ovid Medline and Web of Knowledge. Random-effects models were used. Heterogeneity was assessed with Cochran’s Q and I2 statistics. Publication (small studies) bias was assessed with final plots and the Egger’s test. Study quality was evaluated with the Newcastle Ottawa Scale. Analyses were conducted using Review Manager and Comprehensive Meta-Analysis. FindingsFrom a pool of 3359 non-duplicate potentially relevant references, 47 datasets were included in the meta-analyses. Subjective and objective sleep outcome measures were extracted from 37 and 15 studies, respectively. Only five studies were based on comorbidity free, medication-naïve participants. Compared with typically developing controls, youth with ASD significantly differed in 10/14 subjective parameters and in 7/14 objective sleep parameters. The average quality score in the Newcastle-Ottawa Scale was 5.9/9.Discussion and clinical implicationsA number of subjective and, to a less extent, objective sleep alterations might characterise youth with ASD, but future studies should assess the impact of pharmacological treatment and psychiatric comorbidities.

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Section: Conclusion and Clinical Implicationssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sleep in youth with autism spectrum disorders: systematic review and meta-analysis of subjective and objective studies

Díaz‐Román

Zhang

Delorme

et al. 2018

Evid Based Mental Health

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“…Rett's disorder, tuberous sclerosis, Smith–Magenis syndrome and Angelman syndrome) (Kotagal and Broomall, 2012; Elrod and Hood, 2015). The sleep disturbances exacerbate cognitive performance deficits and behavioural problems and subsequently entire family distress (Doo and Wing, 2006).…”

Section: Melatonin In the Treatment Of Circadian Rhythm And Sleep Dismentioning

confidence: 99%

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

Zisapel

2018

British J Pharmacology

550

350

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In mammals, a central circadian clock, located in the suprachiasmatic nuclei (SCN) of the hypothalamus, tunes the innate circadian physiological rhythms to the ambient 24 h light–dark cycle to invigorate and optimize the internal temporal order. The SCN‐activated, light‐inhibited production of melatonin conveys the message of darkness to the clock and induces night‐state physiological functions, for example, sleep/wake blood pressure and metabolism. Clinically meaningful effects of melatonin treatment have been demonstrated in placebo‐controlled trials in humans, particularly in disorders associated with diminished or misaligned melatonin rhythms, for example, circadian rhythm‐related sleep disorders, jet lag and shift work, insomnia in children with neurodevelopmental disorders, poor (non‐restorative) sleep quality, non‐dipping nocturnal blood pressure (nocturnal hypertension) and Alzheimer's disease (AD). The diminished production of melatonin at the very early stages of AD, the role of melatonin in the restorative value of sleep (perceived sleep quality) and its sleep‐anticipating effects resulting in attenuated activation of certain brain networks are gaining a new perspective as the role of poor sleep quality in the build‐up of β amyloid, particularly in the precuneus, is unravelled. As a result of the recently discovered relationship between circadian clock, sleep and neurodegeneration, new prospects of using melatonin for early intervention, to promote healthy physical and mental ageing, are of prime interest in view of the emerging link to the aetiology of Alzheimer's disease.Linked ArticlesThis article is part of a themed section on Recent Developments in Research of Melatonin and its Potential Therapeutic Applications. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.16/issuetoc

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“…symptoms which can manifest across a range of psychiatric disorders -occur commonly. Such characteristics can include problems with eating and 'food selectivity' (Marí-Bauset, Zazpe, Mari-Sanchis, Llopis-González & Morales-Suáres-Varella, 2014), sleep disturbance (Elrod & Hood, 2015), emotion dysregulation (Weiss, 2014), and paranoia (Blackshaw, Kinderman, Hare & Hatton, 2001). …”

mentioning

confidence: 99%

Conceptualising paranoia in ASD: A systematic review and development of a theoretical framework

Spain

Sin

Freeman

2016

Research in Autism Spectrum Disorders

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Paranoia, unfounded ideation that others deliberately intend harm, has predominately been studied in schizophrenia. Increasingly, it is recognised that there is a spectrum of severity of excessive mistrust across the general population. Relatively little is known about paranoia in individuals with Autism Spectrum Disorders (ASD), but rates could be expected to be higher given both difficulties in understanding others' mental states and frequent experiences of negative social interactions. A systematic search of English-language peer-reviewed publications was undertaken to synthesise empirical research about paranoia in ASD. Seven studies, comprising a total of 180 ASD participants, met the inclusion criteria. All the studies were cross-sectional, thereby limiting causal interpretations. Individuals with ASD were consistently found to have higher levels of paranoia compared to non-clinical controls, and lower levels than individuals with current psychotic experiences manifesting in the context of schizophrenia. Furthermore, the initial evidence indicates that paranoia in ASD may be linked with theory of mind performance, negative affect, and jumping to conclusions, but not to attributional style. As in typically-developing populations, causal and maintaining mechanisms for paranoia in ASD, against a background of genetic and environmental risk, most likely include cognitive and affective processes interacting with social factors. We hypothesise, however, that core ASD characteristics and associated neurocognitive impairments also serve to precipitate and perpetuate paranoia. A framework to guide further investigation is outlined. Conceptualising paranoia in ASD 1 AbstractParanoia, unfounded fears ideation that others deliberately intend harm, has predominately been studied in schizophrenia. Increasingly, it is recognised that there is a spectrum of severity of excessive mistrust across the general population. Relatively little is known about paranoia in individuals with Autism Spectrum Disorders (ASD), but rates could be expected to be higher given both difficulties in understanding others' mental states and frequent experiences of negative social interactions. A systematic search of English-language peer-reviewed publications was undertaken to synthesise empirical research about paranoia in ASD. Seven studies, comprising a total of 180 ASD participants, met the inclusion criteria.All the studies were cross-sectional, thereby limiting causal interpretations. Individuals with ASD were consistently found to have higher levels of paranoia compared to non-clinical controls, and lower levels than individuals with current psychotic experiences manifesting in the context of schizophrenia. Furthermore, the initial evidence indicates that paranoia in ASD may be linked with theory of mind performance, negative affect, and jumping to conclusions, but not to attributional style. As in typically-developing populations, causal and maintaining mechanisms for paranoia in ASD, against a background of genetic and environ...

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Sleep Differences Among Children With Autism Spectrum Disorders and Typically Developing Peers

Cited by 150 publications

References 62 publications

Sleep in youth with autism spectrum disorders: systematic review and meta-analysis of subjective and objective studies

Sleep in youth with autism spectrum disorders: systematic review and meta-analysis of subjective and objective studies

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

Conceptualising paranoia in ASD: A systematic review and development of a theoretical framework

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