Sleep in youth with autism spectrum disorders: systematic review and meta-analysis of subjective and objective studies

Díaz‐Román, Amparo; Zhang, Junhua; Delorme, Richard; Beggiato, Anita; Cortese, Samuele

doi:10.1136/ebmental-2018-300037

Cited by 97 publications

(94 citation statements)

References 59 publications

(19 reference statements)

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“…Conditions that co‐occur with ASD have diverse pathophysiological characteristics. Studies have found gastrointestinal (GI) symptoms [Holingue, Newill, Lee, Pasricha, & Daniele Fallin, ], sleep disorders [Díaz‐Román, Zhang, Delorme, Beggiato, & Cortese, ], immune‐mediated disorders [Hughes, Mills Ko, Rose, & Ashwood, ], epilepsy [Woolfenden, Sarkozy, Ridley, Coory, & Williams, ], and many other conditions [Kohane et al, ; Mannion, Leader, & Healy, ; Muskens, Velders, & Staal, ; Rydzewska et al, ] to affect substantial numbers of individuals with ASD. Although seemingly distinct, some studies have suggested that certain COCs tend to co‐occur together [Aldinger, Lane, Veenstra‐VanderWeele, & Levitt, ; Fulceri et al, ; Hirata et al, ].…”

Section: Introductionmentioning

confidence: 99%

Clustering of co‐occurring conditions in autism spectrum disorder during early childhood: A retrospective analysis of medical claims data

et al. 2019

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Individuals with autism spectrum disorder (ASD) are frequently affected by co-occurring medical conditions (COCs), which vary in severity, age of onset, and pathophysiological characteristics. The presence of COCs contributes to significant heterogeneity in the clinical presentation of ASD between individuals and a better understanding of COCs may offer greater insight into the etiology of ASD in specific subgroups while also providing guidance for diagnostic and treatment protocols. This study retrospectively analyzed medical claims data from a private United States health plan between years 2000 and 2015 to investigate patterns of COC diagnoses in a cohort of 3,278 children with ASD throughout their first 5 years of enrollment compared to 279,693 children from the general population without ASD diagnoses (POP cohort). Three subgroups of children with ASD were identified by k-means clustering using these COC patterns. The first cluster was characterized by generally high rates of COC diagnosis and comprised 23.7% (n = 776) of the cohort. Diagnoses of developmental delays were dominant in the second cluster containing 26.5% (n = 870) of the cohort. Children in the third cluster, making up 49.8% (n = 1,632) of the cohort, had the lowest rates of COC diagnosis, which were slightly higher than rates observed in the POP cohort. A secondary analysis using these data found that gastrointestinal and immune disorders showed similar longitudinal patterns of prevalence, as did seizure and sleep disorders. These findings may help to better inform the development of diagnostic workup and treatment protocols for COCs in children with ASD.Lay Summary: Medical conditions that co-occur with autism spectrum disorder (ASD) vary significantly from person to person. This study analyzed patterns in diagnosis of co-occurring conditions from medical claims data and observed three subtypes of children with ASD. These results may aid with screening for co-occurring conditions in children with ASD and with understanding ASD subtypes.

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Section: Introductionmentioning

confidence: 99%

Clustering of co‐occurring conditions in autism spectrum disorder during early childhood: A retrospective analysis of medical claims data

et al. 2019

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“…ASD is a pervasive neurodevelopmental disorder, with prevalence between 1/34 and 1/76 (Baio et al, ). Sleep disorders are claimed to be present in up to 80% of ASD children, most often characterized by longer sleep onset latency and reduced sleep efficiency (Diaz‐Roman, Shang, Delorme, Zhang, Delorme, Beggiato, & Cortese, ; Fletcher et al, ; Souders et al, ). However, few studies have utilized polysomnography to objectively explore sleep in children with ASD.…”

Section: Introductionmentioning

confidence: 99%

Atypicalities in sleep and semantic consolidation in autism

Fletcher

Knowland

Walker

et al. 2019

Developmental Science

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Sleep is known to support the neocortical consolidation of declarative memory, including the acquisition of new language. Autism spectrum disorder (ASD) is often characterized by both sleep and language learning difficulties, but few studies have explored a potential connection between the two. Here, 54 children with and without ASD (matched on age, nonverbal ability and vocabulary) were taught nine rare animal names (e.g., pipa). Memory was assessed via definitions, naming and speeded semantic decision tasks immediately after learning (pre‐sleep), the next day (post‐sleep, with a night of polysomnography between pre‐ and post‐sleep tests) and roughly 1 month later (follow‐up). Both groups showed comparable performance at pre‐test and similar levels of overnight change on all tasks; but at follow‐up children with ASD showed significantly greater forgetting of the unique features of the new animals (e.g., pipa is a flat frog). Children with ASD had significantly lower central non‐rapid eye movement (NREM) sigma power. Associations between spindle properties and overnight changes in speeded semantic decisions differed by group. For the TD group, spindle duration predicted overnight changes in responses to novel animals but not familiar animals, reinforcing a role for sleep in the stabilization of new semantic knowledge. For the ASD group, sigma power and spindle duration were associated with improvements in responses to novel and particularly familiar animals, perhaps reflecting more general sleep‐associated improvements in task performance. Plausibly, microstructural sleep atypicalities in children with ASD and differences in how information is prioritized for consolidation may lead to cumulative consolidation difficulties, compromising the quality of newly formed semantic representations in long‐term memory.

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“…Further, we evaluated the full-texts of 86 articles and excluded 60 articles that did not meet all the criteria of this review. Finally, 26 articles meeting all the criteria were included in this umbrella review (see Table 3), including 14 systematic reviews (Arnevik and Helverschou, 2016;Hannon and Taylor, 2013;Hedley and Uljarević, 2018;Kalyva et al, 2016;Menezes et al, 2018;Nickel et al, 2019;Padgett et al, 2010;Richa et al, 2014;Segers and Rawana, 2014;Skokauskas and Gallagher, 2009;Stewart et al, 2006;Vannucchi et al, 2014;Wigham et al, 2017;Zahid and Upthegrove, 2017) and 12 meta-analyses (De Giorgi et al, 2019;Díaz-Román et al, 2018;Elrod and Hood, 2015;Hollocks et al, 2019;Hudson et al, 2019;Lai et al, 2019;Lugo-Marín et al, 2019;Lugo Marín et al, 2018;Morgan et al, 2020;van Steensel et al, 2011;van Steensel and Heeman, 2017;Zheng et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

Prevalence of comorbid psychiatric disorders among people with autism spectrum disorder: An umbrella review of systematic reviews and meta-analyses

Hossain¹,

Khan²,

Sultana³

et al. 2020

Preprint

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<p>With ever-increasing prevalence of various mental disorders worldwide, a comprehensive evaluation of the prevalence of co-occurring psychiatric disorders among individuals with autism spectrum disorder (ASD) is needed to strengthen the knowledge base. This umbrella review aims to summarize the current evidence on the prevalence of comorbid psychiatric disorders among people with ASD. A systematic search of 12 major databases and additional sources was conducted. Any systematically conducted narrative, qualitative, or meta-analytic review reporting the prevalence of psychiatric disorders among people with ASD with no age or geographical restriction were included. From a total of 2755 records, 26 articles representing 14 systematic reviews and 12 meta-analyses met the criteria of this review. The synthesized findings reveal a high burden of comorbid psychiatric disorders among people with ASD, including anxiety disorders, depressive disorders, bipolar and mood disorders, schizophrenia spectrum, suicidal behavior disorders, attention-deficit/hyperactivity disorder, disruptive, impulse-control and conduct disorders amongst diverse age groups, with a majority in younger participants. Most studies were conducted in developed nations, with limited evidence from low and middle-income countries. These synthesized findings provide high-quality evidence for clinical and policy-level decision-making from a global overview of the status of comorbid psychiatric disorders among people with ASD.</p>

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Sleep in youth with autism spectrum disorders: systematic review and meta-analysis of subjective and objective studies

Cited by 97 publications

References 59 publications

Clustering of co‐occurring conditions in autism spectrum disorder during early childhood: A retrospective analysis of medical claims data

Clustering of co‐occurring conditions in autism spectrum disorder during early childhood: A retrospective analysis of medical claims data

Atypicalities in sleep and semantic consolidation in autism

Prevalence of comorbid psychiatric disorders among people with autism spectrum disorder: An umbrella review of systematic reviews and meta-analyses

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