Prevalence of comorbid psychiatric disorders among people with autism spectrum disorder: An umbrella review of systematic reviews and meta-analyses

Hossain, Mahbub; Khan, Nusrat Nabi; Sultana, Abida; Ma, Pengtao; McKyer, E. Lisako J.; Ahmed, Helal Uddin; Purohit, Neetu

doi:10.31124/advance.11497014.v1

Cited by 34 publications

(40 citation statements)

References 32 publications

(73 reference statements)

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“…Rates of co morbid PsD in ASD population, possibly more with atypical affective disturbances [86], present a wide range and vary from 3.6-60% [87]. Also, in a recent umbrella review, the prevalence of schizophrenia spectrum and other psychotic disorders reported in eight systematic reviews and meta-analyses including adults with ASD ranged from 4-67% [25]. The study design and the characteristics of our sample might explain the low rates found in our study.…”

Section: Psychotic Disorder (Psd)mentioning

confidence: 55%

Lifetime Co-Occurring Psychiatric Disorders in Newly Diagnosed Adults with Attention Deficit Hyperactivity Disorder (ADHD) or/and Autism Spectrum Disorder (ASD)

Pehlivanidis

Papanikolaou

Mantas

et al. 2020

Preprint

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Background Co-occurring psychiatric disorders in adults with Attention Deficit Hyperactivity Disorder (ADHD) and/or Autism Spectrum Disorder (ASD) contribute to the burden of the healthcare and possibly to the delay of diagnosis. Aim of the study was to clinically assess the prevalence and compare lifetime co-occurring psychopathology in a sample of newly diagnosed ADHD and/or ASD adults and discuss the diagnostic challenges they pose.Methods The lifetime prevalence rates of ten of the most frequently co-occurring psychiatric diagnoses was registered in 336 adults of normal intelligence who underwent a thorough clinical evaluation for the diagnosis of ADHD and/or ASD for the first time in their lives. Four study groups were formed: the ADHD (n = 151), the ASD (n = 58), the ADHD + ASD (n = 28) and the nonADHD/nonASD (NN) (n = 88) group.Results At least one co-occurring psychopathology was found in 72.8% of the ADHD group, in 50% of the ASD group, in 72.4% of the ADHD + ASD group and in 76.1% of the NN group (p = 0.004). In all groups the most frequent psychiatric disorder was depressive disorder. The only significant difference regarding the patterns of psychiatric co-occurrence between the ADHD, the ASD and NN groups was found for substance use disorder (SUD) (p = 0.001). Also, the proportion of subjects with Bipolar Disorder was significantly greater in the NN group as compared to those with ASD (p = 0.025).Conclusions Our results support the high prevalence of co-occurring psychiatric disorders in adults with ADHD and/or ASD with the ASD group presenting the lowest rate. The most marked difference between the ADHD and the nonADHD groups was found for SUD. Moreover, our findings highlight the need for a thorough clinical assessment of all referred patients both in the presence and absence of ADHD and/or ASD.

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Section: Psychotic Disorder (Psd)mentioning

confidence: 55%

Lifetime Co-Occurring Psychiatric Disorders in Newly Diagnosed Adults with Attention Deficit Hyperactivity Disorder (ADHD) or/and Autism Spectrum Disorder (ASD)

Pehlivanidis

Papanikolaou

Mantas

et al. 2020

Preprint

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“…Since 2015, many umbrella reviews have been conducted evaluating the evidence base on the psychosocial epidemiology of mental health in diverse populations [19][20][21][22][23][24]. However, no umbrella review or review of the reviews was found, which can inform the mental health implications of quarantine and isolation for infection prevention at the global landscape.…”

Section: Introductionmentioning

confidence: 99%

Mental health outcomes of quarantine and isolation for infection prevention: A systematic umbrella review of the global evidence

Hossain

Sultana²,

Purohit

2020

Preprint

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Background: Transmission of infectious diseases is often prevented by quarantine and isolation of the populations at risk. These approaches restrict the mobility, social interactions, and daily activities of the affected individuals. In recent novel coronavirus disease (COVID-19) pandemic, quarantine and isolation are being adopted in many contexts, which necessitates an evaluation of global evidence on how such measures impact the mental health outcomes among populations. This umbrella review aimed to synthesize the available evidence on mental health outcomes of quarantine and isolation for preventing infectious diseases.Materials and methods: We searched nine major databases and additional sources and included articles if they were systematically conducted reviews, published as peer-reviewed journal articles, and reported mental health outcomes of quarantine or isolation in any population.Results: Among 1364 citations, only eight reviews met our criteria. Most of the primary studies in those reviews were conducted in high-income nations and in hospital settings. These articles reported a high burden of mental health problems among patients, informal caregivers, and healthcare providers who experienced quarantine or isolation. Prevalent mental health problems among the affected individuals include depression, anxiety, mood disorders, psychological distress, posttraumatic stress disorder, insomnia, fear, stigmatization, low self-esteem, lack of self-control, and other adverse mental health outcomes.Conclusion: This umbrella review found severe mental health problems among individuals and populations who have undergone quarantine and isolation in different contexts. This evidence necessitates multipronged interventions including policy measures for strengthening mental health services globally and promoting psychosocial wellbeing among high-risk populations.

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“…Psychiatric comorbidity in ASD is still under-investigated, even if nearly 70% of people with ASD, including children and adolescents, experience at least one comorbid psychiatric disorder, and around 40% may have two or more psychiatric disorders [ 9 , 26 , 27 ]. Regarding the different comorbidities in ASD, the prevalence of mood disorder among 21,797 participants with ASD has been reported as 18.8% (95% CI: 10.6–31.1) [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Suicidal Ideation and Suicidal Attempts in Referred Adolescents with High Functioning Autism Spectrum Disorder and Comorbid Bipolar Disorder: A Pilot Study

et al. 2020

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Suicidal ideation and attempts in adolescents are closely associated to bipolar disorders (BD). Growing evidence also suggests that high functioning autism spectrum disorders (HF-ASD) are at increased risk for suicidal ideation and behaviors. Although BD and HF-ASD are frequently comorbid, no studies explored suicidality in these individuals. This exploratory study addressed this issue in a clinical group of inpatient adolescents referred to a psychiatric emergency unit. Seventeen adolescents with BD and HF-ASD and severe suicidal ideation or attempts (BD-ASD-S), were compared to 17 adolescents with BD and HF-ASD without suicidal ideation or attempts (BD-ASD-noS), and to 18 adolescents with BD and suicidal ideation or attempts without ASD (BD-noASD-S), using a structured assessment methodology. Individuals with BD-ASD-S had a higher intelligence quotient, more severe clinical impairment, more lethality in suicide attempts, more internalizing symptoms, less impulsiveness, and lower social competence. Severity of ASD traits in individuals and parents did not correlate with suicidal risk. Some dimensions of resilience were protective in terms of repulsion by life and attraction to death. Main limitations are the small sample size, the lack of a control group of typically developing adolescents. However, a better understanding of the specificities of bipolar HF-ASD individuals with suicidality may improve prevention and treatment strategies.

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Prevalence of comorbid psychiatric disorders among people with autism spectrum disorder: An umbrella review of systematic reviews and meta-analyses

Cited by 34 publications

References 32 publications

Lifetime Co-Occurring Psychiatric Disorders in Newly Diagnosed Adults with Attention Deficit Hyperactivity Disorder (ADHD) or/and Autism Spectrum Disorder (ASD)

Lifetime Co-Occurring Psychiatric Disorders in Newly Diagnosed Adults with Attention Deficit Hyperactivity Disorder (ADHD) or/and Autism Spectrum Disorder (ASD)

Mental health outcomes of quarantine and isolation for infection prevention: A systematic umbrella review of the global evidence

Suicidal Ideation and Suicidal Attempts in Referred Adolescents with High Functioning Autism Spectrum Disorder and Comorbid Bipolar Disorder: A Pilot Study

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