Sleep and mild cognitive impairment

Cassidy-Eagle, Erin; Siebern, Allison T.

doi:10.1186/s41606-017-0016-5

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…In fact, the neurotrophin hypothesis proposes that stress-related mental disorders result from a stress-induced decrease in BDNF expression [ 15 ]. In this sense, both primary and secondary sleep disorders have been associated with reduced serum BDNF levels [ 16 , 17 ] and with the subsequent development of cognitive impairment, as seen during aging [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Insomnia Impairs Both the Pro-BDNF and the BDNF Levels Similarly to Older Adults with Cognitive Decline: An Exploratory Study

Sánchez-García

Moreno-Tamayo

Ramírez‐Aldana

et al. 2023

IJMS

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Sleep disorders, including insomnia, are common during aging, and these conditions have been associated with cognitive decline in older adults. Moreover, during the aging process, neurotransmitters, neurohormones, and neurotrophins decrease significantly, leading to the impairment of cognitive functions. In this sense, BDNF, the most abundant neurotrophic factor in the human brain, has been suggested as a potential target for the prevention and improvement of cognitive decline during aging; however, the current evidence demonstrates that the exogenous administration of BDNF does not improve cognitive function. Hence, in the present study, we quantified pro-BDNF (inactive) and BDNF (active) concentrations in serum samples derived from older individuals with insomnia and/or cognitive decline. We used linear regression to analyze whether clinical or sociodemographic variables impacted the levels of BNDF concentration. We observed that insomnia, rather than cognitive decline, is significantly associated with BDNF concentration, and these effects are independent of other variables. To our knowledge, this is the first study that points to the impact of insomnia on improving the levels of BDNF during aging and suggests that opportune treatment of insomnia may be more beneficial to prevent cognitive decline during aging.

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Section: Introductionmentioning

confidence: 99%

Insomnia Impairs Both the Pro-BDNF and the BDNF Levels Similarly to Older Adults with Cognitive Decline: An Exploratory Study

Sánchez-García

Moreno-Tamayo

Ramírez‐Aldana

et al. 2023

IJMS

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“…Approximately 40% of geriatric patients aged 65 and above experience sleep disturbances. [1] There are several continuous and profound changes that contribute to the aging process and affect sleep in the elderly. Both physical and psychological changes that occur during aging can influence a person's sleep quality and quantity.…”

Section: Introductionmentioning

confidence: 99%

Sleep and Cognitive Impairment in the Elderly

Kencana Dewi,

Laksmidewi,

Widyastuti

2023

Int J Sci Healthcare Res

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Elderly people have various types of health problems, not only related to degenerative processes but sleep disturbances are also one of the problems that are often faced by elderly patients. Elderly sleep disorders are very varied and cannot be underestimated. Sleep disorders in the elderly can be in the form of insomnia, obstructive sleep apnea, and sleep related movement. Good management will help the elderly to have good quality sleep and prevent long-term drug use. Sleep disorders in the elderly also cannot be ruled out from various metabolic diseases and psychological stress, so an understanding of sleep disorders in the elderly is needed. This review aims to present a brief review of sleep disorders in the elderly, so that understanding regarding sleep disorders can be further understood. Keywords: Elderly, Sleep disorder, Good Quality of Sleep

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“…There exist evidences that circadian rhythm disruption is a symptom of neurodegeneration, which in turn changes ADLs patterns [33][34][35]. Recently, a relationship has been suggested between sleep characteristics and cognitive decline in the older adults, emphasizing the fact that sleep and cognition are closely related [36][37][38][39][40][41][42]. The authors in [43] present a one year study with 77 older adults (21 mild AD, 27 moderate to severe AD and 29 control subjects).…”

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confidence: 99%

Anomaly Detection in Activities of Daily Living with Linear Drift

et al. 2020

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Background: Anomaly detection in Activities of Daily Living (ADL) plays an important role in e-health applications. An abrupt change in ADL taken by a subject might indicate that she/he needs some help. Another important issue related with e-health application is the case where the change in ADL experiments a linear drift, this is the case in cognitive decline, Alzheimer disease or dementia. Methods: This work presents a novel method for detecting a linear drift in ADL modeled as circular normal distributions. The method is based on techniques commonly used in Statistical Process Control, and is able to detect and estimate the change point in time when a linear drift started.

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Sleep and mild cognitive impairment

Cited by 4 publications

References 39 publications

Insomnia Impairs Both the Pro-BDNF and the BDNF Levels Similarly to Older Adults with Cognitive Decline: An Exploratory Study

Insomnia Impairs Both the Pro-BDNF and the BDNF Levels Similarly to Older Adults with Cognitive Decline: An Exploratory Study

Sleep and Cognitive Impairment in the Elderly

Anomaly Detection in Activities of Daily Living with Linear Drift

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