Insomnia Impairs Both the Pro-BDNF and the BDNF Levels Similarly to Older Adults with Cognitive Decline: An Exploratory Study

Sánchez-García, Sergio; Moreno-Tamayo, Karla; Ramírez‐Aldana, Ricardo; García-Peña, Carmen; Medina-Campos, Raúl Hernán; García-delaTorre, Paola; Rivero-Segura, Nadia Alejandra

doi:10.3390/ijms24087387

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…EX-HN 18 is an extraordinary acupoint for insomnia, associated with cognitive decline in older adults. Treatment of insomnia can help prevent cognitive decline during ageing ( 68 , 69 ). HT 7 is a specific acupoint of the heart meridian, which can regulate the mind and emotion, research shows that later-life emotional disorder increase the risk of cognitive impairment ( 70 ), and the gut microbes are involved in the onset and development of mood disturbance ( 71 ).…”

Section: Discussionmentioning

confidence: 99%

Clinical observation and mechanism of acupuncture on amnestic mild cognitive impairment based on the gut-brain axis: study protocol for a randomized controlled trial

et al. 2023

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BackgroundAmnestic mild cognitive impairment (aMCI) is a pre-dementia condition associated with declined cognitive function dominated by memory impairment. The occurrence of aMCI is associated with the gut-brain axis. Previous studies have shown cognitive improvements in MCI after acupuncture treatment. This study evaluates whether acupuncture can produce a therapeutic effect in patients with aMCI by modulating the gut-brain axis.Methods and designThis is a prospective, parallel, multicenter randomized controlled trial. A total of 40 patients with aMCI will be randomly assigned to an acupuncture group (AG) or a waiting-list group (WG), participants in both groups will receive health education on improving cognitive function at each visit, and acupuncture will be conducted twice a week for 12 weeks in the AG. Another 20 matched healthy volunteers will be enrolled as normal control. The primary outcome will be the change in Alzheimer’s Disease Assessment Scale-cognitive scale score before and after treatment. Additionally, functional magnetic resonance imaging data, faeces, and blood will be collected from each participant to characterize the brain function, gut microbiota, and inflammatory cytokines, respectively. The differences between patients with aMCI and healthy participants, and the changes in the AG and WG groups before and after treatment will be observed. Ultimately, the correlation among brain function, gut microbiota, inflammatory cytokines, and clinical efficacy evaluation in patients with aMCI will be analyzed.DiscussionThis study will identify the efficacy and provide preliminary data on the possible mechanism of acupuncture in treating aMCI. Furthermore, it will also identify biomarkers of the gut microbiota, inflammatory cytokines, and brain function correlated with therapeutic effects. The results of this study will be published in peer-reviewed journals.Clinical trial registrationhttp://www.chictr.org.cn, identifier ChiCTR2200062084.

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Section: Discussionmentioning

confidence: 99%

Clinical observation and mechanism of acupuncture on amnestic mild cognitive impairment based on the gut-brain axis: study protocol for a randomized controlled trial

et al. 2023

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“… Authors, year Study population, insomnia definition Biomaterial Findings 1. Sanchez-Garcia et al 2023 102 Twenty-one insomnia patients and 22 healthy controls. Insomnia was defined as scoring at least 6 points on the AIS questionnaire.…”

Section: Bdnf and Stressmentioning

confidence: 99%

Investigating the Role of BDNF in Insomnia: Current Insights

Ditmer,

Gabryelska,

Turkiewicz

et al. 2023

NSS

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Insomnia is a common disorder defined as frequent and persistent difficulty initiating, maintaining, or going back to sleep. A hallmark symptom of this condition is a sense of nonrestorative sleep. It is frequently associated with other psychiatric disorders, such as depression, as well as somatic ones, including immunomediated diseases. BDNF is a neurotrophin primarily responsible for synaptic plasticity and proper functioning of neurons. Due to its role in the central nervous system, it might be connected to insomnia of multiple levels, from predisposing traits (neuroticism, genetic/epigenetic factors, etc.) through its influence on different modes of neurotransmission (histaminergic and GABAergic in particular), maintenance of circadian rhythm, and sleep architecture, and changes occurring in the course of mood disturbances, substance abuse, or dementia. Extensive and interdisciplinary evaluation of the role of BDNF could aid in charting new areas for research and further elucidate the molecular background of sleep disorder. In this review, we summarize knowledge on the role of BDNF in insomnia with a focus on currently relevant studies and discuss their implications for future projects.

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“…Pro-BDNF is cleaved and activated to BDNF by plasmin that regulates the memory process and neuronal activity. Thus, through activation of the BDNF pathway, tPA improves synaptic plasticity in AD [ 49 ]. Therefore, modulation of tPA/PAI-1 could be a therapeutic strategy in managing AD (Fig.…”

Section: Plasminogen Activating System In Admentioning

confidence: 99%

The probable role of tissue plasminogen activator/neuroserpin axis in Alzheimer’s disease: a new perspective

Ali,

Al-kuraishy,

Al-Gareeb

et al. 2023

Acta Neurol Belg

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Alzheimer’s disease (AD) is the most common type of dementia associated with amyloid beta (Aβ) deposition. Dysfunction of the neuronal clearance pathway promotes the accumulation of Aβ. The plasminogen-activating system (PAS) is controlled by various enzymes like tissue plasminogen activators (tPA). Neuronal tPA enhances the conversion of plasminogen to plasmin, which cleaves Aβ; this function is controlled by many inhibitors of PAS, including a plasminogen-activating inhibitor (PAI-1) and neuroserpin. Therefore, the objective of the present narrative review was to explore the potential role of tPA/neuroserpin in the pathogenesis of AD. PAI-1 activity is increased in AD, which is involved in accumulating Aβ. Progressive increase of Aβ level during AD neuropathology is correlated with the over-production of PAI-1 with subsequent reduction of plasmin and tPA activities. Reducing plasmin and tPA activities promote Aβ by reducing Aβ clearance. Neuroserpin plays a critical role in the pathogenesis of AD as it regulates the expression and accumulation of Aβ. Higher expression of neuroserpin inhibits the neuroprotective tPA and the generation of plasmin with subsequent reduction in the clearance of Aβ. These observations raise conflicting evidence on whether neuroserpin is neuroprotective or involved in AD progression. Thus, neuroserpin over-expression with subsequent reduction of tPA may propagate AD neuropathology. Graphical abstract

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Insomnia Impairs Both the Pro-BDNF and the BDNF Levels Similarly to Older Adults with Cognitive Decline: An Exploratory Study

Cited by 5 publications

References 48 publications

Clinical observation and mechanism of acupuncture on amnestic mild cognitive impairment based on the gut-brain axis: study protocol for a randomized controlled trial

Clinical observation and mechanism of acupuncture on amnestic mild cognitive impairment based on the gut-brain axis: study protocol for a randomized controlled trial

Investigating the Role of BDNF in Insomnia: Current Insights

The probable role of tissue plasminogen activator/neuroserpin axis in Alzheimer’s disease: a new perspective

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