Skin replica analysis of photodamaged skin after therapy with tretinoin emollient cream

Grove, Gary L.; Grove, Mary Jo; Leyden, James J.; Lufrano, Laura; Schwab, B.; Perry, Barbara H.; Thorne, E. George

doi:10.1016/0190-9622(91)70187-7

Cited by 87 publications

(52 citation statements)

References 7 publications

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“…In an earlier 12-week study 10 of the safety and efficacy of 0.1% tazarotene gel on photodamaged forearm skin, statistically significant smoothening of the skin surface, when compared with baseline, was detected using this method. Optical profilometry results also have been found to be consistent with clinical evaluations in reports 12 of the efficacy of 0.05% tretinoin emollient cream in the treatment of photodamaged facial skin.…”

Section: Commentsupporting

confidence: 72%

“…Excluded were any volunteers who had used topical glycolic acid, ␣-hydroxy acid, salicylic acid, lactic acid, or ␤-hydroxy acid or vitamin A, ascorbic acid-, or vitamin E-containing products within 14 days before study enrollment and those who had used topical or systemic retinoids within 6 months before study enrollment. Pregnant and nursing women were excluded, and women of childbearing potential were required to use a reliable form of contraception, have a normal menstrual cycle, and have a negative urine pregnancy test result at baseline (week 0) and at weeks 4,8,12,16,20, and 24. Written informed consent was obtained from all subjects, and the study was conducted in compliance with Good Clinical Practices, Institutional Human Review Board Regulations, and the Declaration of Helsinki.…”

Section: Study Populationmentioning

confidence: 99%

“…Evaluations were conducted at a pretreatment screening visit, at weeks 0 (baseline), 2,4,8,12,16,20, and 24, and 2 weeks posttreatment (week 26).…”

Section: Clinical Evaluationsmentioning

confidence: 99%

See 2 more Smart Citations

Tazarotene Cream for the Treatment of Facial Photodamage

Kang¹,

Leyden²,

Lowe³

et al. 2001

Arch Dermatol

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Section: Commentsupporting

confidence: 72%

Section: Study Populationmentioning

confidence: 99%

See 1 more Smart Citation

Tazarotene Cream for the Treatment of Facial Photodamage

Kang¹,

Leyden²,

Lowe³

et al. 2001

Arch Dermatol

Self Cite

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“…The clinical improvements in skin texture in these 6-months studies have been validated by skin replica measurements of the cheek and crow's feet areas [23]. Computerized analysis showed dose-related responses.…”

Section: Treatment With Topical Tretinoinmentioning

confidence: 97%

Treatment Options for Photodamaged Skin

Griffiths¹

1997

Skin Pharmacol Physiol

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Photodamage of the skin can be a detriment to physical and psychological health with a consequent negative impact on both personal and professional life. Medical treatments for photodamaged skin include topical all-trans-retinoic acid (tretinoin) as well as moisturizers, chemical peels, dermabrasion, Α hydroxy acids and cosmetic surgery. Of these treatment options, only tretinoin has been subjected to large-scale, controlled studies to substantiate its clinical efficacy and long-term benefits. This review summarizes the use of various therapies and presents available clinical and histologic results of systematic trials, including the few studies of retinoid compounds other than tretinoin. Among the extensive data on topical tretinoin are long-term treatment results that provide evidence of ultrastructural changes. These histologic findings suggest that fundamental cellular effects may be responsible for the clinical benefits, which are sustained even when treatment frequency is reduced. It thus appears that tretinoin therapy at least partially restores photodamaged skin to the predamaged state.

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“…Several categories of solutions, based on the use of active ingredients, have been developed. Among them, retinoids, a family of compounds derived from vitamin A, or molecules which interact with retinoid receptors and produce similar biological effects, decrease the severity of skin aging [19][20][21][22]. Retinoids counteract some of the physiological causes leading to the appearance of skin aging signs.…”

Section: Introductionmentioning

confidence: 99%

A Placebo-Controlled Study Demonstrates the Long-Lasting Anti-Aging Benefits of a Cream Containing Retinol, DihydroxyMethylChromone (DMC) and Hyaluronic Acid

Oddos¹,

Roure²,

Leyden³

et al. 2012

JCDSA

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Retinol is an ingredient used in cosmetic products for reducing the appearance of the signs of aging and photo-damage. Currently, most of these products contain 0.1% of retinol. However, at this concentration, some irritation can occur. We have evaluated in vitro and in a clinical study the potential efficacy of a combination of actives to improve the facial skin aging signs while using low concentration of retinol. We demonstrated, in vitro, that a chromone derivative, 5,7-di-hydroxy-2-methyl chromone (DMC), is able to enhance the collagen synthesis in culture of normal human dermal fibroblasts. The enhancement of retinol anti-wrinkle efficacy by DMC was confirmed in a small scale clinical trial. Specifically, a product associating low concentration of retinol (0.04%) and DMC (0.1%) in combination with low molecular weight hyaluronic acid fragments (50,000 Dalton of average molecular weight) has been applied topically for 8 weeks. Clinical results show significant improvement of various signs of facial skin aging such as wrinkles, pigmentary spots, tone unevenness, dullness and the overall photo-damage score. Improvements were still visible 4 weeks after the cessation of the test product application. This study demonstrates that significant lasting improvement of facial skin aging can be obtained with well tolerated low concentration of retinol when adequately formulated with other anti-aging ingredients.

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Skin replica analysis of photodamaged skin after therapy with tretinoin emollient cream

Cited by 87 publications

References 7 publications

Tazarotene Cream for the Treatment of Facial Photodamage

Tazarotene Cream for the Treatment of Facial Photodamage

Treatment Options for Photodamaged Skin

A Placebo-Controlled Study Demonstrates the Long-Lasting Anti-Aging Benefits of a Cream Containing Retinol, DihydroxyMethylChromone (DMC) and Hyaluronic Acid

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