Tazarotene Cream for the Treatment of Facial Photodamage

Efficacy of 0.1% Tazarotene Cream for the Treatment of Photodamage

“…The percentage of patients achieving at least a 1-grade improvement in fine wrinkling, mottled hyperpigmentation, lentigines, and elastosis was significantly higher in tazarotenetreated patients than in vehicle-treated patients (PՅ.05). 4 In addition, 0.1% tazarotene cream showed greater levels of improvement than lower concentration formulations of tazarotene. To further evaluate the long-term efficacy and safety of 0.1% tazarotene cream in the treatment of photodamage, a 12-month study was performed.…”

“…1,2 Tazarotene has been shown to offer efficacy in the treatment of photodamage. 3,4 In a pilot, double-blind, randomized, paired comparison of 10 healthy volunteers, oncedaily applications of 0.1% tazarotene gel to moderately photodamaged forearm skin for 12 weeks resulted in significantly fewer peaks and valleys in silicone skin surface replicas (indicating smoothening of the skin surface) and significantly reduced pigmentary mottling (PՅ.05). 3 Positive changes in cellular architecture were also evident histologically, both in this study 3 as well as in a larger histological safety study (unpublished data, 2001), with a reduction in atypia and a restoration of keratinocyte po- Clinical efficacy has also been confirmed in a larger 6-month, double-blind, randomized, dose-ranging study involving 349 patients with photodamaged facial skin.…”

A review of tazarotene in the treatment of photodamaged skin

“…In order to further investigate the use of tazarotene in photodamaged skin, Kang et al conducted a larger multicenter randomized double-blind vehicle-controlled parallel comparison of 0.01%, 0.025%, 0.05% and 0.1% tazarotene creams against 0.05% tretinoin emollient cream and vehicle cream applied once daily for 24 weeks (Kang et al 2001). Allergan Inc. funded the study of 349 volunteers aged 18 years or over with moderate facial photodamage as based on a 6-point scale at baseline using a photonumeric guideline (0 indicates no photodamage; 3, moderate photodamage; 5 very severe photodamage).…”

Retinoids for the Cosmetic Patient

“…A second retinoid used for cosmetic indications is tazoratene. Tazoratene has been shown to be at least as effective as tretinoin for remodeling of the epidermis and dermis (Kang et al 2001 ). At the present time, this molecule has been marketed as a treatment for acne and psoriasis as well as photorejuvenation.…”