Skin Microbiome in Cutaneous T-Cell Lymphoma by 16S and Whole-Genome Shotgun Sequencing

Salava, Alexander; Deptula, Paulina; Lyyski, Annina; Laine, Pia; Paulín, Lars; Väkevä, Liisa; Ranki, Annamari; Auvinen, Petri; Lauerma, Antti

doi:10.1016/j.jid.2020.03.951

Cited by 27 publications

(28 citation statements)

References 41 publications

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“…Indeed, CTCL exhibits an impaired skin barrier and deficient expression of several AMPs leads to increased susceptibility for skin infections and bacterial toxins may play a major role in driving disease progression [55,59,67,68]. Since microbial colonization is not consistent between CTCL patients, as shown in an early study by Axelrod et al [14] and extended by two investigations utilizing microbiomics [20,21], differential microbial colonization may account for transcriptional heterogeneity.…”

Section: Single Cell Transcriptome Signatures Suggest Microbial Influ...mentioning

confidence: 99%

“…Salava et al used 16S and WMS to investigate the microbiome on early stage CTCL lesions while using non-lesional skin of the same patients as an internal control [21]. WMS data delivered higher resolution in the genus of propionibacteria as compared to 16s sequencing and subsequent analysis is therefore based on WMS.…”

Section: Microbiome On Ctcl Lesionsmentioning

confidence: 99%

“…In general, several microbiota or a dysfunctional microbial community can influence cancers and other skin diseases [18,19]. Regarding CTCL, the complex microbiome patterns possibly influencing the course of this disease have only recently begun to be investigated [20,21]. Genomic methods to study microbiota can provide deep insights into shifted microbial communities relating disease [19].…”

Section: Introductionmentioning

confidence: 99%

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Transcriptional Heterogeneity and the Microbiome of Cutaneous T-Cell Lymphoma

Licht

Mailänder

2022

Cells

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Cutaneous T-Cell Lymphomas (CTCL) presents with substantial clinical variability and transcriptional heterogeneity. In the recent years, several studies paved the way to elucidate aetiology and pathogenesis of CTCL using sequencing methods. Several T-cell subtypes were suggested as the source of disease thereby explaining clinical and transcriptional heterogeneity of CTCL entities. Several differentially expressed pathways could explain disease progression. However, exogenous triggers in the skin microenvironment also seem to affect CTCL status. Especially Staphylococcus aureus was shown to contribute to disease progression. Only little is known about the complex microbiome patterns involved in CTCL and how microbial shifts might impact this malignancy. Nevertheless, first hints indicate that the microbiome might at least in part explain transcriptional heterogeneity and that microbial approaches could serve in diagnosis and prognosis. Shaping the microbiome could be a treatment option to maintain stable disease. Here, we review current knowledge of transcriptional heterogeneity of and microbial influences on CTCL. We discuss potential benefits of microbial applications and microbial directed therapies to aid patients with CTCL burden.

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Section: Single Cell Transcriptome Signatures Suggest Microbial Influ...mentioning

confidence: 99%

Section: Microbiome On Ctcl Lesionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Transcriptional Heterogeneity and the Microbiome of Cutaneous T-Cell Lymphoma

Licht

Mailänder

2022

Cells

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“… 108 A recent study based on 16S rRNA and whole-genome shotgun sequencing revealed a relative reduction in a suite of opportunistic pathogens in active mycosis fungoides skin lesions compared with that in contralateral healthy-looking skin. 109 Moreover, increased early oral exposure to the microbiome conveys a protective role for young adult HL, 110 and maladjusted microbiota of the oral cavity and conjunctiva have been reported in cases with paediatric ALL and conjunctival MALT lymphoma, respectively. 111 , 112 While the mechanistic role is undefined, these data highlight that the commensal microbiome outside the GIT may play a role in malignant lymphocyte transformation and consequently may serve as a therapeutic target.…”

Section: Associations Of Microorganisms Beyond the Git With Lymphomamentioning

confidence: 99%

Emerging Roles for the Gut Microbiome in Lymphoid Neoplasms

Shi

Zhang

2021

Clin Med Insights Oncol

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Lymphoid neoplasms encompass a heterogeneous group of malignancies with a predilection for immunocompromised individuals, and the disease burden of lymphoid neoplasms has been rising globally over the last decade. At the same time, mounting studies delineated a crucial role of the gut microbiome in the aetiopathogenesis of various diseases. Orchestrated interactions between myriad microorganisms and the gastrointestinal mucosa establish a defensive barrier for a range of physiological processes, especially immunity and metabolism. These findings provide new perspectives to harness our knowledge of the gut microbiota for preclinical and clinical studies of lymphoma. Here, we review recent findings that support a role for the gut microbiota in the development of lymphoid neoplasms and pinpoint relevant molecular mechanisms. Accordingly, we propose the microbiota-gut-lymphoma axis as a promising target for clinical translation, including auxiliary diagnosis, novel prevention and treatment strategies, and predicting clinical outcomes and treatment-related adverse effects of the disease in the future. This review will reveal a fascinating avenue of research in the microbiota-mediated lymphoma field.

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“…Furthermore, the human microbiota has tremendous potential to impact multiple human physiological functions including immune homeostasis (Belkaid and Hand, 2014). Dysbiosis, alterations of the microbial communities that lead to detrimental effects on the host, has been proposed to contribute to the genesis of several diseases of the lymphohematopoietic system, including Hodgkin lymphoma, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, acute lymphoblastic leukemia and cutaneous T cell lymphoma (Cozen et al, 2013;Raderer et al, 2016;Rajagopala et al, 2016;Salava et al, 2020). Of them, Helicobacter pylori infection with gastric MALT lymphoma constitutes a paradigm for microbiota-driven malignancy (Raderer et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Characteristics and Clinical Implications of the Nasal Microbiota in Extranodal NK/T-Cell Lymphoma, Nasal Type

Shi

Wang

et al. 2021

Front. Cell. Infect. Microbiol.

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Natural killer/T cell lymphoma (NKTCL) most frequently affects the nasal cavity and upper aerodigestive tract (UAT) and is often mistaken for reactive disease processes, such as chronic rhinosinusitis (CRS). Recently, alterations of the nasal resident microbiota have been found in CRS. However, nasal microbial features in NKTCL have never been reported. This case-control study collected 46 NKTCL patients, 25 CRS patients and 24 matched healthy controls (HCs) to analyze nasal microbial profiles via 16S rRNA sequencing technology to improve our understanding of changes in the nasal microbiota in NKTCL. We found that alpha diversity was significantly decreased, while beta diversity was significantly increased in NKTCL compared with those in CRS and HCs. The genus Corynebacterium was significantly depleted in CRS and NKTCL versus that in HCs, while genus Staphylococcus was the most abundant in the NKTCL compared to that in the other two groups. The nasal microbial community was significantly different between UAT-NKTCL and non-UAT NKTCL patients. Importantly, based on a panel of taxa, excellent classification power with an AUC of 0.875 between UAT-NKTCL and CRS was achieved. Furthermore, the alpha diversity of the nasal microbiota was associated with several clinical covariates of NKTCL. Finally, PICRUSt analysis implicated an array of distinct functions in NKTCL that might be involved in the pathogenesis of the disease. In conclusion, the nasal microbial profile was unique in NKTCL. The nose-microbiota-UAT NKTCL axis represents a panel of promising biomarkers for clinical practice and contributes to revealing the potential pathogenesis of this malignancy.

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Skin Microbiome in Cutaneous T-Cell Lymphoma by 16S and Whole-Genome Shotgun Sequencing

Cited by 27 publications

References 41 publications

Transcriptional Heterogeneity and the Microbiome of Cutaneous T-Cell Lymphoma

Transcriptional Heterogeneity and the Microbiome of Cutaneous T-Cell Lymphoma

Emerging Roles for the Gut Microbiome in Lymphoid Neoplasms

Characteristics and Clinical Implications of the Nasal Microbiota in Extranodal NK/T-Cell Lymphoma, Nasal Type

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