Emerging Roles for the Gut Microbiome in Lymphoid Neoplasms

Shi, Zhuangzhuang; Zhang, Mingzhi

doi:10.1177/11795549211024197

Cited by 14 publications

(13 citation statements)

References 127 publications

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“…Of note, alterations of the gut microbiota have been associated with increased estrogen deconjugation through the secretion of βglucuronidase, suggesting the possibility of estrogen-related malignancy developing due to microbiota alteration [28] . In addition, gut microbiota closely participates in the development of lung cancer [29] . Furthermore, a supportive role for the gut microbiota has been shown in the development of lymphoid neoplasms [30] .…”

Section: Gut-cancer Axis In Carcinogenesismentioning

confidence: 99%

Roles of gut dysbiosis, anti-proliferative proteins, and post-transcriptional regulation in carcinogenesis

Sawamura¹,

Taniguchi²,

Ikeda³

et al. 2022

J Transl Genet Genom

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The potentially powerful impact of microbiota has attracted much attention. For example, dysbiosis of the gut microbiota could be linked to various cancers. It is probable that DNA damage and DNA repair impairment due to inflammation from gut dysbiosis would be of importance in carcinogenesis and/or preventing carcinogenesis. In fact, the signature of the gut microbiome has been shown to be associated with responses and/or successful survival rate to certain immune-blockade therapy in several cancers. Conversely, living cells have to cope with the danger of reactive oxygen species (ROS) disturbing the integrity of biomolecules, which can eventually lead to carcinogenesis if otherwise untreated. Gut microbiota could modulate considerable levels of ROS and oxidative damage. Interestingly, an anti-proliferative family (APRO) characterized by several immediate early responsive gene products might be deeply involved in the mechanism of carcinogenesis. It has been described that APRO proteins also participate in a variety of cellular processes including cell division, DNA repair, and mRNA stability. The biological function of APRO proteins seems to be quite complicated; however, they might be a key modulator of microRNAs (miRNAs) for post-transcriptional regulation. The next generation of therapy would likely contain strategies for modifying the redox background as well as the regulation of ROS in cells and/or for better DNA repair machinery with the APRO proteins via the modulation of miRNA-derived post-transcriptional regulation in a sustainable manner. Given the important function of the gut microbiota in balancing the immune network, carcinogenesis could therefore be prevented by suitable gut microbiota via the roles of APRO proteins. Consequently, probiotics might play a key role in the modulation of gut immune system in keeping healthy and/or preventing cancers.

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Section: Gut-cancer Axis In Carcinogenesismentioning

confidence: 99%

Roles of gut dysbiosis, anti-proliferative proteins, and post-transcriptional regulation in carcinogenesis

Sawamura¹,

Taniguchi²,

Ikeda³

et al. 2022

J Transl Genet Genom

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“…H. pylori-associated gastric mucosa-associated lymphoid tissue lymphomas (MALT lymphomas) are usually treated with just antibiotics leading to clinical remission [ 50 , 51 ]. Changes in the composition of microbiota are associated with T-cell lymphoma, cutaneous B-cell lymphoma, MALT, and Hodgkin’s lymphomas [ 52 , 53 ]. Gut microbiota also influences chemotherapy toxicity.…”

Section: Reviewmentioning

confidence: 99%

Diagnostic and Therapeutic Uses of the Microbiome in the Field of Oncology

Anipindi¹,

Bitetto²

2022

Cureus

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Cancer is a leading cause of death worldwide and it can affect almost every part of the human body. Effective screening and early diagnosis of cancers is extremely difficult due to the multifactorial etiology of the disease and delayed presentation of the patients. The available treatments are usually not specific to the affected organ system, leading to intolerable systemic side effects and early withdrawal from therapies. In vivo and in vitro studies have revealed an association of specific microbiome signatures with individual cancers. The cancer-related human microbiome has also been shown to affect the response of tissues to chemotherapy, immunotherapy, and radiation. This is an excellent opportunity for us to design specific screening markers using the microbiome to prevent cancers and diagnose them early. We can also develop precise treatments that can target cancer-affected specific organ systems and probably use a lesser dose of chemotherapy or radiation for the same effect. This prevents adverse effects and early cessation of treatments. However, we need further studies to exactly clarify and characterize these associations. In this review article, we focus on the association of the microbiome with individual cancers and highlight its future role in cancer screenings, diagnosis, prognosis, and treatments.

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“…Shi et al [43] reviewed recent reports that support a role for the gut microbiota in the occurrence of lymphoid neoplasms and pinpoint relevant molecular mechanisms. Accordingly, they proposed the microbiota-gut-lymphoma axis as a promising target for clinical translation, including auxiliary diagnosis, novel prevention, and treatment strategies [43]. They predicted clinical outcomes and treatment-related side effects of the disease in the future [43].…”

Section: Gut Microbiome Dysbiosis In Various Malignanciesmentioning

confidence: 99%

“…Accordingly, they proposed the microbiota-gut-lymphoma axis as a promising target for clinical translation, including auxiliary diagnosis, novel prevention, and treatment strategies [43]. They predicted clinical outcomes and treatment-related side effects of the disease in the future [43]. The gut microbiota has been shown to be an important determinant of the efficacy of immune checkpoint inhibitions (ICI) for patients with cancer [44].…”

Section: Gut Microbiome Dysbiosis In Various Malignanciesmentioning

confidence: 99%

New Horizon on Gut Microbiome and Cancers: Recent Information on Pathogenesis and Treatment

Fukui¹

2022

AJIM

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An increasing number of studies have suggested that gut microbiota is closely related to tumor pathogenesis and their treatments. Among cancers, there have been many reports concerning gut microbiome and colon cancer (CRC), where microbial dysbiosis with depressing the population of "benign microbes" and increasing "harmful microbes" can lead to chronic enterocolitis and cancer development with progression. In addition, gut dysbiosis may change the metabolism of bile acids promoting CRC, which would offer a potential preventive therapeutic change in CRC by regulating gut microbiome and bile acid metabolism. Recently, SARS-CoV-2 impacts the gut microbiota, and the effects will have on CRC carcinogenesis. Obesity is estimated as an important factor that increases the risk of CRC. There has been accumulating evidence that the modulation of the gut microbiota composition by probiotics, prebiotics, and diets protects patients with CRC. Hepatocellular carcinoma (HCC) as the third leading cause of worldwide cancer mortality. Development of HCC in cirrhotic patients is related to changes in intestinal microbiome, including an escalation of dysbiosis and reduced bacterial richness. The species richness of fecal microbiota of hepatitis B-HCC patients was much high. The alterations of fecal microbiome may affect the process of Helicobacter pylori (H. pylori)-related progression of gastric lesion. Patients with gastric cancer have distinct microbiome in the stomach with lower biodiversity. Some bacteria from gastric microbiome are potentially carcinogenic as they are changed in gastric cancer. Patients with pancreas cancer and cholangiocarcinoma have also been related to gut dysbiosis. Other malignancies outside the gut like breast cancer (BC) might be related to gut microbiome as they might affect through metabolic, neural, and endocrine signal and immune function in the occurrence and progression of BC. Finally, cancer cachexia might be also associated with gut dysbiosis as it is closely related to bile acids (BA) metabolism regulation. The effects and side effects by variable cancer therapies such as chemotherapy, radiotherapy and also immunotherapy may be reconsidered from gut microbiome.

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Emerging Roles for the Gut Microbiome in Lymphoid Neoplasms

Cited by 14 publications

References 127 publications

Roles of gut dysbiosis, anti-proliferative proteins, and post-transcriptional regulation in carcinogenesis

Roles of gut dysbiosis, anti-proliferative proteins, and post-transcriptional regulation in carcinogenesis

Diagnostic and Therapeutic Uses of the Microbiome in the Field of Oncology

New Horizon on Gut Microbiome and Cancers: Recent Information on Pathogenesis and Treatment

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