Skin Lycopene Is Destroyed Preferentially over β-Carotene during Ultraviolet Irradiation in Humans

Ribaya-Mercado, Judy D.; Garmyn, Marjan; Gilchrest, Barbara A.; Russell, Robert M.

doi:10.1093/jn/125.7.1854

Cited by 180 publications

(89 citation statements)

References 32 publications

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“…The importance of ascorbic acid and ␣-tocopherol was suggested by decreases of these antioxidants in skin levels with concomitant formation of lipid hydroperoxides during UV irradiation of murine skin, and the formation of squalene hydroperoxides in human skin upon UV exposure, respectively (Yamamoto, 2001). Carotenoids such as lycopene and ␤-carotene also attenuated the disorders elicited by UV irradiation (Ribaya-Mercado et al, 1995;Stahl et al, 2001). Although feeding red bell pepper attenuated the increase in the grading score in SAMP8 in our previous study, supplementation with lycopene or tomato could not do.…”

Section: Discussioncontrasting

confidence: 54%

Amelioratory Effect of Dietary Ingestion of Lycopene and Tomato Rich in Lycopene on Learning Impairment in Senescence-Accelerated Mice (SAMP8).

Suganuma¹,

Kaburagi²,

Inakuma³

et al. 2002

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We previously reported that the dietary ingestion of red bell pepper (Capsicum annuum L.) which contained a large amount of antioxidative carotenoids ameliorated the age-related phenomena of learning disorder and degradation of hair glossiness in the senescence-accelerated mouse (SAM). As lycopene is one of the most popular carotenoids in human serum and exists in abundance in tomato, we examined the effects of dietary lycopene and tomato rich in lycopene on the age-related disorders in SAMP8//Kgm, a mouse model of accelerated decline in learning and memory, and control SAMR1//Kgm mice. SAMP8 mice that received a diet containing 0.02% (w/w) lycopene or 20% (w/w) tomato powder showed much better acquisition in passive avoidance tasks than those given the control diet. Dietary lycopene and tomato had no effect on the ability of learning and memory in SAMR1 mice. Those observations indicated that the dietary ingestion of lycopene in tomato ameliorated the learning impairment in SAMP8.

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Section: Discussioncontrasting

confidence: 54%

Amelioratory Effect of Dietary Ingestion of Lycopene and Tomato Rich in Lycopene on Learning Impairment in Senescence-Accelerated Mice (SAMP8).

Suganuma¹,

Kaburagi²,

Inakuma³

et al. 2002

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“…Although nutrients were not measured in the skin itself, previous studies showed that the profiles of carotenoids, ␣-tocopherol, and retinoids in blood and skin are comparable (26,27). Moreover, many vitamins have been shown in the skin and in skin-surface lipids derived from sebum and corneocytes, including vitamin A, ␣-and ␤-carotene, lycopene, lutein, zeaxanthin, and ␤-cryptoxanthin (28)(29)(30).…”

Section: Discussionmentioning

confidence: 99%

Human skin condition and its associations with nutrient concentrations in serum and diet

Boelsma

Vijver

Goldbohm

et al. 2003

The American Journal of Clinical Nutrition

108

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Background: Nutritional factors exert promising actions on the skin, but only scant information is available on the modulating effects of physiologic concentrations of nutrients on the skin condition of humans. Objective: The objective was to evaluate whether nutrient concentrations in serum and diet are associated with the skin condition of humans. Design: A cross-sectional study was conducted in which data on serum concentrations of nutrients, dietary intake of nutrients, and the hydration, sebum content, and surface pH of skin were obtained from 302 healthy men and women. Skin condition was measured with the use of noninvasive techniques. Dietary intake was assessed with 2 complementary food-frequency questionnaires. Multiple regression analysis was used to evaluate associations of serum vitamins and carotenoids and of dietary micro-and macronutrients with skin condition. Results: After adjustment for potential confounders, including sex, age, and smoking, statistically significant associations were shown in the total population between serum vitamin A and skin sebum content and surface pH and between the dietary intake of total fat, saturated fat, monounsaturated fat, and skin hydration. Monounsaturated fat intake was also associated with surface pH. Associations between serum ␤-cryptoxanthin and skin hydration and between surface pH and fluid and calcium intakes were observed in men only. Conclusion: Several associations between nutrients in serum and diet and skin condition were observed, indicating that changes in baseline nutritional status may affect skin condition.Am J Clin Nutr 2003;77:348-55.

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“…It has also been shown that ␤-carotene and lycopene are effective protectors of lymphocyte cells from nitrogen dioxide radical damage, but lycopene is at least twice as effective as ␤-carotene (6). RibayaMercado et al (7) showed that when skin is subjected to ultraviolet light stress, more lycopene is destroyed than ␤-carotene, suggesting a role of lycopene in mitigating oxidative damage in tissues.…”

Section: Introductionmentioning

confidence: 99%

Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage?

Riso¹,

Pinder²,

Santangelo³

et al. 1999

The American Journal of Clinical Nutrition

204

102

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Background: Lycopene, the main carotenoid in tomato, has been shown to be a potent antioxidant in vitro. However, there is no significant evidence of its antioxidant action in vivo. Objective: We evaluated the effect of tomato intake on plasma carotenoid concentrations and lymphocyte resistance to oxidative stress. Design: Ten healthy women (divided into 2 groups of 5 subjects each) ate a diet containing tomato purée (providing 16.5 mg lycopene) and a tomato-free diet for 21 d each in a crossover design. Before and after each diet period, plasma carotenoid concentrations and primary lymphocyte resistance to oxidative stress (evaluated by means of single-cell gel electrophoresis) were analyzed. Results: After the first 21-d experimental period, total plasma lycopene concentrations increased by 0.5 mol/L (95% CI: 0.14, 0.87) in the group that consumed the tomato diet and decreased by 0.2 mol/L (95% CI: Ϫ0.11, Ϫ0.30) in the group that consumed the tomato-free diet (P < 0.001). Tomato consumption also had an effect on cellular antioxidant capacity: lymphocyte DNA damage after ex vivo treatment with hydrogen peroxide decreased by 33% (95% CI: 0.8%, 61%; P < 0.05) and by 42% (95% CI: 5.1%, 78%; P < 0.05) in the 2 groups of subjects after consumption of the tomato diet. Conclusion:The consumption of tomato products may reduce the susceptibility of lymphocyte DNA to oxidative damage. Am J Clin Nutr 1999;69:712-8.

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Skin Lycopene Is Destroyed Preferentially over β-Carotene during Ultraviolet Irradiation in Humans

Cited by 180 publications

References 32 publications

Amelioratory Effect of Dietary Ingestion of Lycopene and Tomato Rich in Lycopene on Learning Impairment in Senescence-Accelerated Mice (SAMP8).

Amelioratory Effect of Dietary Ingestion of Lycopene and Tomato Rich in Lycopene on Learning Impairment in Senescence-Accelerated Mice (SAMP8).

Human skin condition and its associations with nutrient concentrations in serum and diet

Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage?

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