Amelioratory Effect of Dietary Ingestion of Lycopene and Tomato Rich in Lycopene on Learning Impairment in Senescence-Accelerated Mice (SAMP8).

Suganuma, Hiroyuki; Kaburagi, Sachiko; Inakuma, Takahiro; Ishiguro, Yukiko

doi:10.3136/fstr.8.183

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…54,56,57,[202][203][204] Lycopene has a protective effect against neurological disorders including Alzheimer's and PD by reducing oxidative stress. [205][206][207][208][209][210][211] Lycopene supplementation of a rotenone-induced rat model of PD enhances the protective effect against oxidative stress and reduces neurobehavioral abnormalities. 208 However, bioavailability in the gastrointestinal tract was limited after oral administration.…”

Section: Nanolycopenementioning

confidence: 99%

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Ganesan¹,

Ko²,

Kim³

et al. 2015

IJN

102

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Oxidative stress plays a very critical role in neurodegenerative diseases, such as Parkinson’s disease (PD), which is the second most common neurodegenerative disease among elderly people worldwide. Increasing evidence has suggested that phytobioactive compounds show enhanced benefits in cell and animal models of PD. Curcumin, resveratrol, ginsenosides, quercetin, and catechin are phyto-derived bioactive compounds with important roles in the prevention and treatment of PD. However, in vivo studies suggest that their concentrations are very low to cross blood–brain barrier thereby it limits bioavailability, stability, and dissolution at target sites in the brain. To overcome these problems, nanophytomedicine with the controlled size of 1–100 nm is used to maximize efficiency in the treatment of PD. Nanosizing of phytobioactive compounds enhances the permeability into the brain with maximized efficiency and stability. Several nanodelivery techniques, including solid lipid nanoparticles, nanostructured lipid carriers, nanoliposomes, and nanoniosomes can be used for controlled delivery of nanobioactive compounds to brain. Nanocompounds, such as ginsenosides (19.9 nm) synthesized using a nanoemulsion technique, showed enhanced bioavailability in the rat brain. Here, we discuss the most recent trends and applications in PD, including 1) the role of phytobioactive compounds in reducing oxidative stress and their bioavailability; 2) the role of nanotechnology in reducing oxidative stress during PD; 3) nanodelivery systems; and 4) various nanophytobioactive compounds and their role in PD.

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Section: Nanolycopenementioning

confidence: 99%

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Ganesan¹,

Ko²,

Kim³

et al. 2015

IJN

102

View full text Add to dashboard Cite

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“…25) The liver tissues or the feed materials were homogenized and saponified by addition of 60% KOH and 3% butylated hydroxytoluene in ethanol, followed by heating at 50°C for 30 min. After extraction with hexane and dichloromethane (4 : 1, v/v, 5.0 ml) twice, the samples were dried and then reconstituted in a sufficient quantity of the mobile phase.…”

Section: Cd8mentioning

confidence: 99%

The Feeding of .BETA.-Carotene Down-Regulates Serum IgE Levels and Inhibits the Type I Allergic Response in Mice

Sato

Akiyama

Suganuma³

et al. 2004

Biological & Pharmaceutical Bulletin

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The incidence of type I allergic disorders is increasing; particularly, hypersensitivity to food and airborne allergens.1-3) The mechanism of Type I allergy includes a series of events, 4,5) namely, production of antigen-specific IgE, binding of IgE to the FceRI receptor on mast cells or basophiles, cross-linking of IgE with newly absorbed allergens, and release of chemical mediators such as histamine and leukotrienes from cells. Inhibition of any of the steps in this sequence leads to the attenuation of allergic symptoms. Several drugs, such as corticosteroids, epinephrine, histamine antagonists, and leukotriene synthesis inhibitors, interfere with the above reactions. 6) However, the effect of these drugs is short-lived, and thus, a more fundamental means of preventing allergies would be desirable.It has been reported in numerous observational epidemiological studies that the intake of vegetables, including carrots, is associated with the prevention of several degenerative diseases.7-13) These reports suggest that vegetables have the potential to modulate or regulate the host immune response, resulting in an overall beneficial effect on the immune response. We have already shown evidence that the feeding of carrots (Daucas carota L. var. sativa DC.) to BALB/c mice sensitized with ovalbumin (OVA) inhibited IgE and IgG1 production.14) However, it is still unclear what kind of components in carrots could exhibit this activity.b-Carotene is one of the major nutritional components and is present at high levels especially in carrots. On the other hand, much attention has also been paid to the role of bcarotene intake in the prevention of cancer and life style-related diseases, such as cardiovascular disease. [15][16][17] In the present study, we examined the feeding of bcarotene on the production of specific IgE antibody, specific IgG1 antibody and specific IgG2a antibody. We also examined the effect of feeding b-carotene on antigen-induced active systemic anaphylactic shock (ASA), such as the decrease in body temperature and the rise of serum histamine levels. Furthermore, to clarify the active mechanism by b-carotene intake in the inhibition of specific IgE production, we examined the pattern of cytokine production by spleen cells from mice fed carrots. MATERIALS AND METHODS Mice and Drinking ProtocolsFemale BALB/c mice, 3-4 weeks of age, were purchased from Japan SLC (Hamamatsu, Shizuoka, Japan). Mice were maintained in a temperature (23-25°C)-, humidity (40-60%)-and light-controlled environment. Animals were allowed free access to a powdered MF diet (Japan SLC) and water throughout the experiment. The MF diet containing b-carotene was prepared by mixing the MF diet with levels of b-carotene of 20 mg/kg. The control group (nϭ5) and the b-carotene group (nϭ5) had free access to the MF diet and the MF diet containing bcarotene, respectively.As far as dose-dependent study was concerned, spiked levels in the MF diet were 0 mg/kg (nϭ5), 2 mg/kg (nϭ5), 10 mg/kg (nϭ5) and 20 mg/kg (nϭ5). The care and use of the experime...

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“…Dietary management with aged-garlic extracts, red bell pepper (Capsicum annuum L.) and lycopene/tomato extracts enhance Lipkin (1999); Ramirez-Tortosa et al 1999;Kelloff et al (2000); Louajri et al (2001). memory and learning of senescence-accelerated mice (Youdim and Joseph 2001;Suganuma et al 2002).…”

Section: Neuroprotective Antioxidantsmentioning

confidence: 99%

Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging

Ferrari

2004

Biogerontology

193

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Aging is associated with mitochondrial dysfunctions, which trigger membrane leakage, release of reactive species from oxygen and nitrogen and subsequent induction of peroxidative reactions that result in biomolecules' damaging and releasing of metals with amplification of free radicals discharge. Free radicals induce neuronal cell death increasing tissue loss, which could be associated with memory detriment. These pathological events are involved in cardiovascular, neurodegenerative and carcinogenic processes. Dietary bioactive compounds from different functional foods, herbs and nutraceuticals (ginseng, ginkgo, nuts, grains, tomato, soy phytoestrogens, curcumin, melatonin, polyphenols, antioxidant vitamins, carnitine, carnosine, ubiquinone, etc.) can ameliorate or even prevent diseases. Protection from chronic diseases of aging involves antioxidant activities, mitochondrial stabilizing functions, metal chelating activities, inhibition of apoptosis of vital cells, and induction of cancer cell apoptosis. Functional foods and nutraceuticals constitute a great promise to improve health and prevent aging-related chronic diseases.

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Amelioratory Effect of Dietary Ingestion of Lycopene and Tomato Rich in Lycopene on Learning Impairment in Senescence-Accelerated Mice (SAMP8).

Cited by 5 publications

References 35 publications

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

The Feeding of .BETA.-Carotene Down-Regulates Serum IgE Levels and Inhibits the Type I Allergic Response in Mice

Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging

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Amelioratory Effect of Dietary Ingestion of Lycopene and Tomato Rich in Lycopene on Learning Impairment in Senescence-Accelerated Mice (SAMP8).

Cited by 5 publications

References 35 publications

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson&rsquo;s disease models

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson&rsquo;s disease models

The Feeding of .BETA.-Carotene Down-Regulates Serum IgE Levels and Inhibits the Type I Allergic Response in Mice

Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging

Contact Info

Product

Resources

About

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models