Human skin condition and its associations with nutrient concentrations in serum and diet

Boelsma, Esther; Vijver, L.P.L. van de; Goldbohm, R. Alexandra; Klöpping-Ketelaars, Ineke A. A.; Hendriks, H.; Roza, Len

doi:10.1093/ajcn/77.2.348

Cited by 108 publications

(88 citation statements)

References 34 publications

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“…1A. The stratum corneum water content in the control group was significantly lower at weeks 4,6,8,10, and 12 than week 0. In the collagen group, water content was significantly higher at week 2 and lower at week 10 than week 0.…”

Section: Methodsmentioning

confidence: 80%

“…In the collagen group, water content was significantly higher at week 2 and lower at week 10 than week 0. Twelve weeks of oral administration of collagen hydrolysate caused significantly higher values in water content compared with the control group at weeks 4,6,8,10, and 12. Skin elasticity data are shown in Fig.…”

Section: Methodsmentioning

confidence: 87%

“…Collagen hydrolysate is manufactured from the hydrolysis of gelatin with proteases. Dietary supplementation with food ingredients, such as vitamins and polyphenols, helps modulate skin function (4,18,47). We have also reported that repetitive collagen hydrolysate administration improved the loss of epidermal barrier function and skin elasticity in hairless mice following a single dose or repeated doses of ultraviolet B (UV-B) irradiation (32).…”

mentioning

confidence: 99%

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Effect of orally administered collagen hydrolysate on gene expression profiles in mouse skin: a DNA microarray analysis

Oba¹,

Ito²,

Ichikawa³

et al. 2015

Physiological Genomics

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Oba C, Ito K, Ichikawa S, Morifuji M, Nakai Y, Ishijima T, Abe K, Kawahata K. Effect of orally administered collagen hydrolysate on gene expression profiles in mouse skin: a DNA microarray analysis. Physiol Genomics 47: [355][356][357][358][359][360][361][362][363] 2015. First published June 9, 2015; doi:10.1152/physiolgenomics.00009.2015.-Dietary collagen hydrolysate has been hypothesized to improve skin barrier function. To investigate the effect of long-term collagen hydrolysate administration on the skin, we evaluated stratum corneum water content and skin elasticity in intrinsically aged mice. Female hairless mice were fed a control diet or a collagen hydrolysate-containing diet for 12 wk. Stratum corneum water content and skin elasticity were gradually decreased in chronologically aged control mice. Intake of collagen hydrolysate significantly suppressed such changes. Moreover, we used DNA microarrays to analyze gene expression in the skin of mice that had been administered collagen hydrolysate. Twelve weeks after the start of collagen intake, no significant differences appeared in the gene expression profile compared with the control group. However, 1 wk after administration, 135 genes were upregulated and 448 genes were downregulated in the collagen group. This suggests that gene changes preceded changes of barrier function and elasticity. We focused on several genes correlated with functional changes in the skin. Gene Ontology terms related to epidermal cell development were significantly enriched in upregulated genes. These skin function-related genes had properties that facilitate epidermal production and differentiation while suppressing dermal degradation. In conclusion, our results suggest that altered gene expression at the early stages after collagen administration affects skin barrier function and mechanical properties. Long-term oral intake of collagen hydrolysate improves skin dysfunction by regulating genes related to production and maintenance of skin tissue. collagen hydrolysate; skin aging; epidermal barrier function; skin elasticity; DNA microarray SKIN AGING IS MAINLY CLASSIFIED into two categories: chronological aging and photoaging. Chronological aging, or so-called "physiological aging," indicates natural age-induced intrinsic changes. Chronologically aged skin is characterized by dry skin, atrophy, laxity, and wrinkling. As skin ages, the rate of cell division of keratinocytes slows down and the reduced cell number induces epidermal thinning and flattening of the epidermal-dermal junction (7, 31) and results in decreased epidermal thickness (17). Loss of natural moisture factors and intercellular lipids such as ceramide induce dry skin, and there is a reduction of epidermal barrier function (13, 39). Additionally, fibroblast dysfunction and extracellular matrix (ECM) alterations appear in the dermis with aging. Decreases in the content of glycosaminoglycan, proteoglycans, and degeneration of collagenous and elastic fibers induce a decline in skin elasticity, wrinkle formation, and sa...

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Section: Methodsmentioning

confidence: 80%

Section: Methodsmentioning

confidence: 87%

mentioning

confidence: 99%

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Effect of orally administered collagen hydrolysate on gene expression profiles in mouse skin: a DNA microarray analysis

Oba¹,

Ito²,

Ichikawa³

et al. 2015

Physiological Genomics

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show abstract

“…No association between the nutrients in diet and sebum content of the skin have been found. However, increased serum vitamin A levels were related with decreased sebum content [12]. It has been suggested that caloric restriction can reduce sebum release.…”

Section: Discussionmentioning

confidence: 99%

Relationship between diet and seborrheic dermatitis

Tamer¹

2018

Our Dermatol Online

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“…Moreover, the moisture value may also be affected by the type of consumed foods. One of the studies has shown that epidermal hydration is decreased as a result of the diet rich in saturated or monounsaturated fatty acids [43].…”

mentioning

confidence: 99%

Structural and biophysical characteristics of human skin in maintaining proper epidermal barrier function

Boer¹,

Duchnik²,

Maleszka³

et al. 2016

pdia

185

178

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A b s t r a c tThe complex structure of human skin and its physicochemical properties turn it into an efficient outermost defence line against exogenous factors, and help maintain homeostasis of the human body. This role is played by the epidermal barrier with its major part -stratum corneum. The condition of the epidermal barrier depends on individual and environmental factors. The most important biophysical parameters characterizing the status of this barrier are the skin pH, epidermal hydration, transepidermal water loss and sebum excretion. The knowledge of biophysical skin processes may be useful for the implementation of prophylactic actions whose aim is to restore the barrier function.Key words: epidermal barrier, sebum, skin hydration, transepidermal water loss, skin pH. Skin is a barrier between the human body and the external environment. It protects the body against exogenous chemical and physical factors, takes part in the metabolic processes, plays a resorptive and thermoregulatory function, being the first line of defence against pathogenic microorganisms, and it partakes in immunological processes [1]. Review paperThe complex structure of human skin and its physicochemical characteristics turn it into an effective outermost defence line against exogenous factors, and help maintain homeostasis of the human body. This role is played by the epidermal barrier, in which the corneal layer of epidermis has a particularly important function to perform [1][2][3]. It consists of 15-20 layers of fully cornified keratinocytescorneocytes. In the bottom part of the cornified layer, the cells closely adjoin each other, while in the top part they are arranged loosely and undergo scaling. Construction of the corneal layer resembles a wall in which corneocytes stand for bricks, and a fat-abundant intercellular matrix is the cement [4,5]. The interior of the corneal layer cells is filled with cytokeratin filaments bonded with filaggrin. These cells are surrounded by a stiff, cornified encasement built mostly of the loricrin protein, forming a part of the so-called protein-lipid envelope [2,3,6]. The envelope is connected with the extracellular liquid crystal matrix and constitutes the border between the hydrophilic surface of the cells and the lipophilic non-polar fatty acids of the matrix surrounding corneocytes [7].The thickness of the outer layer of the epidermis, the size of corneocytes, and the composition of superficial lipids impact the regenerative properties of the skin, which contributes to the various courses of dermatological diseases, and the process of healing alike. Anatomical areas with thick epidermis are more resistant to external factors [8]. On the other hand, the areas with a relatively thin cornified layer, such as the face, are characterized by high susceptibility to damaging factors, but also by the ability to re-establish the barrier function very fast. It is connected with a high proliferative activity, thus quick regeneration of the epidermis, intensive vascularity, good hydration, and pr...

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Human skin condition and its associations with nutrient concentrations in serum and diet

Cited by 108 publications

References 34 publications

Effect of orally administered collagen hydrolysate on gene expression profiles in mouse skin: a DNA microarray analysis

Effect of orally administered collagen hydrolysate on gene expression profiles in mouse skin: a DNA microarray analysis

Relationship between diet and seborrheic dermatitis

Structural and biophysical characteristics of human skin in maintaining proper epidermal barrier function

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