Skin Diseases of Endocrine Origin (Dyshormonal Dermatoses)

Some skin manifestations in hypoparathyroidism

“…Amongst them the frequent occurrence of keratosis palmaris et plantaris is striking. It has been observed to accompany ectodermal dysplasias by MacKee & Andrews (1924), Tobias (1925), Janitzkaja & Rjabow (1928), Clouston (1929, Bloch & Stauffer (1929), Falconer (1929), Brain (1930, Gordon & Jamieson (1931), Fleischmann (1931), Bowen (1932), Dodds (1935, Lord & Wolfe (1938), and Young (1944). L6vy-Franckel & Juster (1923, 1926 accuse a disturbance of the sympathetic and endocrine systems, and Spira (1947) a disturbance of the vegetative nervou system and the parathyroids of producing keratodermias.…”

“…It is now known (Bruhns, 1924;Bloch, 1926) that impetigo herpetiformis is not limited to pregnancy alone, and that it mayaffect non-pregnantwomen and even men as well. Whilst there can be no doubt that each one of the mentioned theories concerning its aetiology is based on very reliable and painstaking observation, it seems reasonable, in view of the recorded additional information available, to suggest that it is the sum of these theories, now further extended by our recent knowledge of the action of fluorine, which appears fully to explain all the aspects of the disease.…”

The Effects of Sulphonamide Compounds Upon Lupus Erythematosus.*

“…Personally I am a supporter ofthe third theory, and I regard these eioiptions as illustrating Bloch's (1929) dictum: "'The type and course of the allergic reaction are independent of the nature of the antigen, but vary according to the localization of the antibody, that is, according to Avhich organ (or tissue) reacts to the antigen." I have elsewhere (1929) discussed the aetiology of these eruptions and their relationship to others that are accepted as being of an allergic nature.…”