Abstract:Several previous studies have investigated the skin aging prevention effects of ceramide, hyaluronic acid, and natural or fermented plant materials. Recently, oral administration and dermal application of probiotics or probiotic lysates have shown antiaging effects. The purpose of this study is to optimize the preparation of probiotic lysates with a high concentration of nucleotides and to confirm the effects of probiotic lysates on the skin. Probiotic lysates were prepared by heating at 121°C for various peri… Show more
Wearing a mask is still advised since COVID-19 continues to spread. However, masks may also irritate the skin and cause mask acne, often known as “maskne”, which is a type of acne mechanica caused by friction between the skin and clothing. Therefore, there is a need to develop an effective maskne cosmetic. In this study, we made the maskne cosmetics containing <i>Humulus lupulus</i> extract and Copper tripeptide-1 and investigated its stability, safety and anti-inflammatory efficacy. The results indicated that the samples were stable after centrifugation, temperature cycling, viscosity, and pH tests. The cell viability range of maskne cosmetics was within 71%-80% at 2.5 mg/mL, which presented a weak cytotoxicity. In addition, cosmetic safety test results revealed that maskne cosmetics containing <i>humulus lupulus</i> extract and copper tripeptide-1 did not cause any skin responses. Expression levels of IL-1β and IL-6 were lowest in HS68 cells after treatment with a lotion containing 3%<i>humulus lupulus</i> extract and 3% Copper tripeptide-1. It was confirmed that maskne cosmetics containing <i>Humulus lupulus extract</i> and Copper tripeptide-1 reduce the expression of inflammatory cytokines IL-1, and IL-6 caused by wearing a mask. These findings indicate that prepared lotion containing 3% <i>Humulus lupulus</i> extract and 3% Copper tripeptide-1 is a promising maskne cosmetic with commercial potential.
Wearing a mask is still advised since COVID-19 continues to spread. However, masks may also irritate the skin and cause mask acne, often known as “maskne”, which is a type of acne mechanica caused by friction between the skin and clothing. Therefore, there is a need to develop an effective maskne cosmetic. In this study, we made the maskne cosmetics containing <i>Humulus lupulus</i> extract and Copper tripeptide-1 and investigated its stability, safety and anti-inflammatory efficacy. The results indicated that the samples were stable after centrifugation, temperature cycling, viscosity, and pH tests. The cell viability range of maskne cosmetics was within 71%-80% at 2.5 mg/mL, which presented a weak cytotoxicity. In addition, cosmetic safety test results revealed that maskne cosmetics containing <i>humulus lupulus</i> extract and copper tripeptide-1 did not cause any skin responses. Expression levels of IL-1β and IL-6 were lowest in HS68 cells after treatment with a lotion containing 3%<i>humulus lupulus</i> extract and 3% Copper tripeptide-1. It was confirmed that maskne cosmetics containing <i>Humulus lupulus extract</i> and Copper tripeptide-1 reduce the expression of inflammatory cytokines IL-1, and IL-6 caused by wearing a mask. These findings indicate that prepared lotion containing 3% <i>Humulus lupulus</i> extract and 3% Copper tripeptide-1 is a promising maskne cosmetic with commercial potential.
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