Effects of Maskne Cosmetics to Inflammation Elicited by Volatile Organic Compounds (VOC)

Abstract

Wearing a mask is still advised since COVID-19 continues to spread. However, masks may also irritate the skin and cause mask acne, often known as “maskne”, which is a type of acne mechanica caused by friction between the skin and clothing. Therefore, there is a need to develop an effective maskne cosmetic. In this study, we made the maskne cosmetics containing <i>Humulus lupulus</i> extract and Copper tripeptide-1 and investigated its stability, safety and anti-inflammatory efficacy. The results indicated that the samples were stable after centrifugation, temperature cycling, viscosity, and pH tests. The cell viability range of maskne cosmetics was within 71%-80% at 2.5 mg/mL, which presented a weak cytotoxicity. In addition, cosmetic safety test results revealed that maskne cosmetics containing <i>humulus lupulus</i> extract and copper tripeptide-1 did not cause any skin responses. Expression levels of IL-1β and IL-6 were lowest in HS68 cells after treatment with a lotion containing 3%<i>humulus lupulus</i> extract and 3% Copper tripeptide-1. It was confirmed that maskne cosmetics containing <i>Humulus lupulus extract</i> and Copper tripeptide-1 reduce the expression of inflammatory cytokines IL-1, and IL-6 caused by wearing a mask. These findings indicate that prepared lotion containing 3% <i>Humulus lupulus</i> extract and 3% Copper tripeptide-1 is a promising maskne cosmetic with commercial potential.