Skeletal Muscle in Alloxan Diabetes: A Comparison of Isometric Contractions in Fast and Slow Muscle

Paulus, Stephen F; Grossie, J.

doi:10.2337/diab.32.11.1035

Cited by 38 publications

(34 citation statements)

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“…Ashton & Webb (1980) reported no change in absolute twitch tension of soleus muscle after 2 weeks of diabetes. Paulus & Grossie (1983) also found no change after this time but by 4 weeks absolute twitch tension was decreased and relative twitch tension had increased in comparison with age-matched controls. Although in the present study these variables were not significantly different compared with either control group a similar trend is seen in comparison with the age-matched group.…”

Section: Discussionmentioning

confidence: 84%

“…A brief report (Ashton & Webb, 1980) suggested differential effects on the fast extensor digitorum longus (EDL) and slow soleus muscles after 2 weeks of streptozotocin diabetes. Grossie (1982) and Paulus & Grossie (1983) examined the properties of EDL and soleus muscles in vitro after 2-4 weeks of alloxan diabetes. Although all the authors were in agreement on some aspects of diabetic muscle changes, there were marked differences; for example, Ashton and Webb reported a speeding in relaxation of EDL, while Grossie found no change.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Long‐term Streptozotocin Diabetes on the Contractile and Histochemical Properties of Rat Muscles

et al. 1989

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SUMMARYContractile and histochemical properties of soleus (a slow-twitch muscle) and extensor digitorum longus (EDL, a fast-twitch muscle) were studied in mature rats after 3 months of streptozotocin-induced diabetes. Results were compared with age-and weight-matched controls. Diabetes produced profound wasting of fast muscles and particularly of the fast glycolytic (FG) fibres. Slow muscle fibres, both within the mixed EDL and in soleus, were less atrophied. Strength performance of EDL was reduced by diabetes, but maintained in soleus. Diabetes was without effect on the time to peak tension (TTP) and half-relaxation time (HRT) of EDL. However it produced profound slowing of soleus muscles, particularly of the relaxation phase. Part of the slowing effect of diabetes may be related to a histochemically demonstrable loss of fast oxidative glycolytic (FOG) fibres in soleus. Histochemical staining for the oxidative marker succinic dehydrogenase (SDH) revealed marked disruption of reaction product distribution in soleus, indicating an impairment of oxidative capacity.

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Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Effects of Long‐term Streptozotocin Diabetes on the Contractile and Histochemical Properties of Rat Muscles

et al. 1989

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“…1977;Krotkiewski and Bjorntorp 1986;Lillioja et al 1987;Gaster et al 2001;29 Oberbach et al 2006). The change in contractile properties is further described by 1 animal studies reporting a more marked diabetes-induced strength loss in fast-twitch 2 muscles (Cotter et al 1989;Sanchez et al 2005) and in skinned fast-twitch single 3 fibers (Paulus and Grossie 1983;Sanchez et al 2005) than in slow-twitch muscles. 4…”

Section: Muscle Fatigue 10mentioning

confidence: 90%

Effect of exercise training on neuromuscular function of elbow flexors and knee extensors of type 2 diabetic patients

Bazzucchi

Vito

Felici

et al. 2015

Journal of Electromyography and Kinesiology

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Massimo (2015) Effect of exercise training on neuromuscular function of elbow flexors and knee extensors of type 2 diabetic patients. Journal of Electromyography and Kinesiology, 25 (5). pp. 815-823.Downloaded from: http://insight.cumbria.ac.uk/2048/ Usage of any items from the University of Cumbria's institutional repository 'Insight' must conform to the following fair usage guidelines.Any item and its associated metadata held in the University of Cumbria's institutional repository Insight (unless stated otherwise on the metadata record) may be copied, displayed or performed, and stored in line with the JISC fair dealing guidelines (available here) for educational and not-for-profit activities provided that• the authors, title and full bibliographic details of the item are cited clearly when any part of the work is referred to verbally or in the written form• a hyperlink/URL to the original Insight record of that item is included in any citations of the work • the content is not changed in any way• all files required for usage of the item are kept together with the main item file. You may not• sell any part of an item• refer to any part of an item without citation • amend any item or contextualise it in a way that will impugn the creator's reputation• remove or alter the copyright statement on an item.The full policy can be found here. Alternatively contact the University of Cumbria Repository Editor by emailing insight@cumbria.ac.uk. Accepted Manuscript

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“…Supporting this hypothesis is the recent finding that long-term diabetes impairs contractile function by affecting presynaptic control at the neuromuscular junction as well as at the muscle cells [19]. There is also evidence that diabetes can directly impair the contractile/regulatory system of a subpopulation of fast-twitch fibres [18,39]. It is interesting to note, in this regard, that nNOS is enriched in fasttwitch compared with slow-twitch fibres [12,26].…”

Section: Discussionmentioning

confidence: 50%

Mechanism of impaired nitric oxide synthase activity in skeletal muscle of streptozotocin-induced diabetic rats

2000

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Type I (insulin-dependent) diabetes mellitus is characterised by pronounced insulin resistance for glucose disposal in skeletal muscle [1,2]. This metabolic impairment is at least in part related to a post-insulin signalling defect in the expression and translocation of GLUT4 glucose transporters to the muscle cell surface [3±5]. The lack of insulin action on glucose metabolism in muscle of people with Type I diabetes could also be explained by an impaired vasodilatory effect of insulin on the muscle vasculature [2], although this impairment has not been confirmed in a more recent study [1]. Several studies have shown that endothelium-dependent relaxation is altered in Abstract Aims/hypothesis. The aims of our study were to investigate whether nitric oxide synthase (NOS) activity is impaired in skeletal muscle of insulin-deficient [Type I (insulin-dependent)] diabetic rats and if the case, to determine the mechanism of NOS dysregulation in this disorder. Methods. Rats were rendered diabetic by streptozotocin injection (65 mg/kg, i. v.) and NOS activity and expression in gastrocnemius muscles were studied 1, 2, 3 or 4 weeks after diabetes induction. Results. The diabetic state was associated with a progressive reduction (down to 42 % of control values after 4 weeks) in muscle NOS activity compared with control rats. Using reverse transcriptase-polymerase chain reaction, we could not detect statistically significant changes in the expression of either neuronal NOS (nNOS) or endothelial NOS (eNOS) mRNAs in diabetic muscle. The contents of nNOS and eNOS protein were, however, progressively reduced in muscle homogenates of diabetic rats and these alterations were prevented by insulin treatment. Subcellular fractionation of skeletal muscle showed that both nNOS and eNOS proteins are mainly localised to the plasma membrane with lower abundance in T-tubules and not detectable in sarcoplasmic reticulum-enriched fractions. After 1 week of diabetes, eNOS protein content was decreased only in the plasma membrane whereas nNOS protein abundance was not affected at this time. Neither the expression nor the interaction of caveolin-1 and caveolin-3 with NOS enzymes was found to be altered in muscle of diabetic rats. Conclusion/interpretation. These results show that skeletal muscle NOS activity is impaired during the progression of insulin-deficient diabetes and reduced NOS activity is associated with a decreased abundance of both nNOS and eNOS proteins, which appears to involve post-transcriptional mechanisms.

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Skeletal Muscle in Alloxan Diabetes: A Comparison of Isometric Contractions in Fast and Slow Muscle

Cited by 38 publications

References 0 publications

Effects of Long‐term Streptozotocin Diabetes on the Contractile and Histochemical Properties of Rat Muscles

Effects of Long‐term Streptozotocin Diabetes on the Contractile and Histochemical Properties of Rat Muscles

Effect of exercise training on neuromuscular function of elbow flexors and knee extensors of type 2 diabetic patients

Mechanism of impaired nitric oxide synthase activity in skeletal muscle of streptozotocin-induced diabetic rats

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