Effect of exercise training on neuromuscular function of elbow flexors and knee extensors of type 2 diabetic patients

Bazzucchi, Ilenia; Vito, Giuseppe De; Felici, Francesco; Dewhurst, Susan; Sgadari, Antonio; Sacchetti, Massimo

doi:10.1016/j.jelekin.2015.06.008

Cited by 19 publications

(19 citation statements)

References 60 publications

(54 reference statements)

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“…In a study on aerobic and resistance training, it has been shown that aerobic capacity improves by 13% and muscle strength improves by 14%–20% in healthy men of the same age as our cohort when exercise is performed twice weekly for 21 weeks . In patients with diabetic neuropathy, muscle strength increases by 11%–19%, and aerobic capacity increases by 12% . In muscle diseases, an improvement of aerobic capacity of 14% was noted in congenital myopathy along with an increase in muscle strength of 60% in limb‐girdle and Becker muscular dystrophies .…”

Section: Discussionsupporting

confidence: 51%

Resistance training and aerobic training improve muscle strength and aerobic capacity in chronic inflammatory demyelinating polyneuropathy

et al. 2017

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Introduction: We investigated the effects of aerobic and resistance exercise in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Methods: Eighteen CIDP patients treated with subcutaneous immunoglobulin performed 12 weeks of aerobic exercise and 12 weeks of resistance exercise after a run-in period of 12 weeks without exercise. Three times weekly the participants performed aerobic exercise on an ergometer bike or resistance exercise with unilateral training of knee and elbow flexion/extension. Primary outcomes were maximal oxygen consumption velocity (VO 2 -max) and maximal combined isokinetic muscle strength (cIKS) of knee and elbow flexion/extension. Results: VO 2 -max and muscle strength were unchanged during run-in (24.9% 6 10.3%, P 5 0.80 and 23.7% 6 10.1%, P 5 0.17, respectively). Aerobic exercise increased VO 2 -max by 11.0% 6 14.7% (P 5 0.02). Resistance exercise resulted in an increase of 13.8% 6 16.0% (P 5 0.0004) in cIKS. Discussion: Aerobic exercise training and resistance exercise training improve fitness and strength in CIDP patients.

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Section: Discussionsupporting

confidence: 51%

Resistance training and aerobic training improve muscle strength and aerobic capacity in chronic inflammatory demyelinating polyneuropathy

et al. 2017

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“…Few studies have examined the mechanisms of fatigability among people with diabetes. Several studies have shown that for isometric contractions with lower-limb muscles (ankle dorsiflexor and knee extensor muscles), people with type 1 diabetes and diabetic polyneuropathy and people with T2D were more fatigable than controls (3,6,8). The mechanisms contributing to greater fatigability in the people with type 1 diabetes who had diabetic polyneuropathy included disruption of neuromuscular transmission indicated by a concomitant decrease in the maximal compound muscle action potential (3) and slowed motor unit conduction velocities and discharge frequencies (6).…”

Section: Introductionmentioning

confidence: 99%

“…There are no other known studies determining the fatigability during dynamic fatiguing tasks in people with T2D, and, furthermore, the mechanisms are unknown. Finally, despite potential differences in fatigability between men and women (25), studies of fatigability in people with T2D have been underpowered to determine whether there are sex-related differences among people with T2D (e.g., 8,18,28,37).…”

Section: Introductionmentioning

confidence: 99%

Mechanisms for the increased fatigability of the lower limb in people with type 2 diabetes

Senefeld

Magill

Harkins

et al. 2018

Journal of Applied Physiology

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Fatiguing exercise is the basis of exercise training and a cornerstone of management of type 2 diabetes mellitus (T2D); however, little is known about the fatigability of limb muscles and the involved mechanisms in people with T2D. The purpose of this study was to compare fatigability of knee extensor muscles between people with T2D and controls without diabetes and determine the neural and muscular mechanisms for a dynamic fatiguing task. Seventeen people with T2D [ten men and seven women: 59.6 (9.0) yr] and twenty-one age-, body mass index-, and physical activity-matched controls [eleven men and ten women: 59.5 (9.6) yr] performed one hundred twenty high-velocity concentric contractions (one contraction/3 s) with a load equivalent to 20% maximal voluntary isometric contraction (MVIC) torque with the knee extensors. Transcranial magnetic stimulation (TMS) and electrical stimulation of the quadriceps were used to assess voluntary activation and contractile properties. People with T2D had larger reductions than controls in power during the fatiguing task [42.8 (24.2) vs. 26.4 (15.0)%; P < 0.001] and MVIC torque after the fatiguing task [37.6 (18.2) vs. 26.4 (12.1)%; P = 0.04]. People with T2D had greater reductions than controls in the electrically evoked twitch amplitude after the fatiguing task [44.0 (20.4) vs. 35.4 (12.1)%, respectively; P = 0.01]. However, the decrease in voluntary activation was similar between groups when assessed with electrical stimulation [12.1 (2.6) vs. 12.4 (4.4)% decrease; P = 0.84] and TMS ( P = 0.995). A greater decline in MVIC torque was associated with larger reductions of twitch amplitude ( r = 0.364, P = 0.002). Although neural mechanisms contributed to fatigability, contractile mechanisms were responsible for the greater knee extensor fatigability in men and women with T2D compared with healthy controls. NEW & NOTEWORTHY Transcranial magnetic stimulation and percutaneous muscle stimulation were used to determine the contributions of neural and contractile mechanisms of fatigability of the knee extensor muscles after a dynamic fatiguing task in men and women with type 2 diabetes (T2D) and healthy age-, body mass index-, and physical activity-matched controls. Although neural and contractile mechanisms contributed to greater fatigability of people with T2D, fatigability was primarily associated with impaired contractile mechanisms and glycemic control.

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“…Moreover, elderly individuals exhibit lower MU discharge rates . However, the cause–effect relation in these age‐related adaptations is unknown, mainly because of the lack of methods that allow direct access to motor neurone behaviour and muscle unit properties concurrently, in large samples of MUs in vivo .…”

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confidence: 99%

Distribution of muscle fibre conduction velocity for representative samples of motor units in the full recruitment range of the tibialis anterior muscle

et al. 2017

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were decomposed into single motor unit action potentials, from which the corresponding motor unit RT, 32 MUCV, and action potential amplitude were estimated. Established relations between muscle fiber diameter 33 and CV were used to estimate the fiber size. 34Results: Within individual subjects, the distributions of MUCV and fiber diameters were unimodal and did 35 not show distinct populations. MUCV was strongly correlated with RT (mean (SD) R 2 = 0.7 (0.09), p<0.001; 36 406 motor units), which supported the hypothesis that fiber diameter is associated to RT. 37 Conclusion

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Effect of exercise training on neuromuscular function of elbow flexors and knee extensors of type 2 diabetic patients

Cited by 19 publications

References 60 publications

Resistance training and aerobic training improve muscle strength and aerobic capacity in chronic inflammatory demyelinating polyneuropathy

Resistance training and aerobic training improve muscle strength and aerobic capacity in chronic inflammatory demyelinating polyneuropathy

Mechanisms for the increased fatigability of the lower limb in people with type 2 diabetes

Distribution of muscle fibre conduction velocity for representative samples of motor units in the full recruitment range of the tibialis anterior muscle

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