Size Distribution and Morphology of Liposome Aerosols Generated By Two Methodologies

Chattopadhyay, Saptarshi; Modesto-López, Luis B.; Venkataraman, Chandra; Biswas, Pratim

doi:10.1080/02786826.2010.498797

Cited by 22 publications

(15 citation statements)

References 32 publications

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“…Additionally, this technology can produce aerosols from dispersed dosage forms . Electrospraying of negatively charged nanoliposomes of DPPC, 1,2‐Dipalmitoyl‐sn‐Glycerol‐3‐[Phospho‐rac‐(1‐glycerol)] sodium salt (DPPGNa) and cholesterol presented a bimodal size distribution (peaks at 35 and 100 nm) caused by different agglomeration patterns inside the capillary nozzle during aerosolization . Head‐to‐tail and side‐by‐side juxtaposition were identified during aerosolization of suspensions with high lipid mass concentration.…”

Section: Emerging Nebulizersmentioning

confidence: 99%

The function and performance of aqueous aerosol devices for inhalation therapy

Carvalho

McConville

2016

Journal of Pharmacy and Pharmacology

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Objectives In this review paper, we explore the interaction between the functioning mechanism of different nebulizers and the physicochemical properties of the formulations for several types of devices, namely jet, ultrasonic and vibrating-mesh nebulizers; colliding and extruded jets; electrohydrodynamic mechanism; surface acoustic wave microfluidic atomization; and capillary aerosol generation. Key findings Nebulization is the transformation of bulk liquids into droplets. For inhalation therapy, nebulizers are widely used to aerosolize aqueous systems, such as solutions and suspensions. The interaction between the functioning mechanism of different nebulizers and the physicochemical properties of the formulations plays a significant role in the performance of aerosol generation appropriate for pulmonary delivery. Certain types of nebulizers have consistently presented temperature increase during the nebulization event. Therefore, careful consideration should be given when evaluating thermo-labile drugs, such as protein therapeutics. We also present the general approaches for characterization of nebulizer formulations. Summary In conclusion, the interplay between the dosage form (i.e. aqueous systems) and the specific type of device for aerosol generation determines the effectiveness of drug delivery in nebulization therapies, thus requiring extensive understanding and characterization.

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Section: Emerging Nebulizersmentioning

confidence: 99%

The function and performance of aqueous aerosol devices for inhalation therapy

Carvalho

McConville

2016

Journal of Pharmacy and Pharmacology

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“…38 This state is contrary to that in transmission electron microscopy analyses in which drying of the samples is required which leads to liposome shrinkage. 39 In DLS analyses we have obtained polydispersity index values close to 0 for both empty and panomycocin loaded SCLLs. This showed that the liposomes were monodisperse as a polydispersity index value closer to 0 in the range of 0-1 is the indication of monodispersity which is a significant factor in the efficacy of drug delivery and the stability studies.…”

Section: Discussionmentioning

confidence: 93%

Stratum corneum lipid liposome-encapsulated panomycocin: preparation, characterization, and the determination of antimycotic efficacy against <em>Candida</em> spp. isolated from patients with vulvovaginitis in an in vitro human vaginal epithelium tissue model

İzgü¹,

Bayram²,

Tosun³

et al. 2017

IJN

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In this study, a liposomal lyophilized powder formulation of panomycocin was developed for therapeutic purposes against vulvovaginal candidiasis which affects 80% of women worldwide. Panomycocin is a potent antimycotic protein secreted by the yeast Wickerhamomyces anomalus NCYC 434. This study involved the preparation of panomycocin-loaded stratum corneum lipid liposomes (SCLLs), characterization of the SCLLs, and determination of antimycotic efficacy of the formulation against Candida albicans and Candida glabrata clinical vaginal isolates in a human vaginal epithelium tissue model. The encapsulation and loading efficiencies of SCLLs were 73% and 76.8%, respectively. In transmission electron microscopy images, the SCLLs appeared in the submicron size range. Dynamic light scattering analyses showed that the SCLLs had uniform size distribution. Zeta potential measurements revealed stable and positively charged SCLLs. In Fourier transform infrared spectroscopy analyses, no irreversible interactions between the encapsulated panomycocin and the SCLLs were detected. The SCLLs retained >98% of encapsulated panomycocin in aqueous solution up to 12 hours. The formulation was fungicidal at the same minimum fungicidal concentration values for non-formulated pure panomycocin when tested on an in vitro model of vaginal candidiasis. This is the first study in which SCLLs and a protein as an active ingredient have been utilized together in a formulation. The results obtained in this study led us to conduct further preclinical trials of this formulation for the development of an effective topical anti-candidal drug with improved safety.

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“…The basic steps in all the gas/vapor phase nanoparticle synthesis are nucleation and condensation of gases and vapor molecules of the precursor, followed by cluster formation and coagulation leading to the formation of primary particles which may further grow into aggregates by sintering, agglomeration and aggregation [72–74]. Various inorganic and organic base nanoparticles including, but not limited to, magnetite, silica, graphene, lipid and titanium dioxide, are used widely as MRI contrast agents, coatings, drug carriers, sensors and coloring agents, as discussed in the previous section, has been reported to be synthesized by flame [75–79], furnace [80], aerosol chemical vapor deposition [81, 82] and electrospray [17, 20, 83, 84]. A typical process of aerosol based nanoparticles and nanostructure synthesis of nanoparticle can be seen in Figure 2.…”

Section: Synthesis Of Nanoparticlesmentioning

confidence: 99%

“…Nanoparticle behavior (toxic or compatible) in the biological matrix depends not only on the type of nanoparticles, but also on the size, shape, crystal phase, surface charge, chemical composition, and agglomeration state [20, 84, 109–111]. Jiang et al, [110] studied reactive oxygen species (ROS) generation capacity of TiO 2 nanoparticles, independent of size range (4–195 nm) and crystal phase (anatase, rutile, amorphous, and mixed phase).…”

Section: Morphological and Physicochemical Characterizationmentioning

confidence: 99%

Perspective on Nanoparticle Technology for Biomedical Use

Raliya¹,

Chadha²,

Haddad³

et al. 2016

CPD

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This review gives a short overview on the widespread use of nanostructured and nanocomposite materials for disease diagnostics, drug delivery, imaging and biomedical sensing applications. Nanoparticle interaction with a biological matrix/entity is greatly influenced by its morphology, crystal phase, surface chemistry, functionalization, physicochemical and electronic properties of the particle. Various nanoparticle synthesis routes, characteristization, and functionalization methodologies to be used for biomedical applications ranging from drug delivery to molecular probing of underlying mechanisms and concepts are described with several examples (150 references).

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Size Distribution and Morphology of Liposome Aerosols Generated By Two Methodologies

Cited by 22 publications

References 32 publications

The function and performance of aqueous aerosol devices for inhalation therapy

The function and performance of aqueous aerosol devices for inhalation therapy

Stratum corneum lipid liposome-encapsulated panomycocin: preparation, characterization, and the determination of antimycotic efficacy against <em>Candida</em> spp. isolated from patients with vulvovaginitis in an in vitro human vaginal epithelium tissue model

Perspective on Nanoparticle Technology for Biomedical Use

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