Six new tigliane diterpenoids with anti-inflammatory activity from Euphorbia kansuensis

Yan, Xue-Long; Chen, Bei-Ling; Yuan, Fang-Yu; Zhu, Qihe; Zhang, Xu; Lin, Yi; Long, Qing-De; Liao, Shang‐Gao

doi:10.1016/j.arabjc.2022.103807

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…Base on the Boltzmann distribution theory and their relative Gibbs free energy (ΔG), the ECD spectra was produced by using SpecDis. [37][38][39] The theoretical ECD spectra of enantiomer was obtained by inverting that of calculated value.…”

Section: Nmr Calculationsmentioning

confidence: 99%

Chemical Constituents of Ajuga Lupulina and their Anti‐Ferroptosis Activity

Teng,

Shi,

Cao

et al. 2024

Chemistry & Biodiversity

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Five new compounds (1, 2, 7, 12, and 16), along with fifteen known ones, were isolated from Ajuga lupulina Maxim. Their structures were elucidated by spectroscopic data (MS, NMR) analysis, and the absolute configuration was determined by the experimental and calculated ECD spectra. Compound 16, with eight carbon atoms, was firstly isolated from the nature. All the isolates were assayed for their anti‐ferroptosis in RSL3‐induced HT22 mouse hippocampal neuronal cells. Among them, the abietane‐type diterpenoids (7‒11) significantly inhibited RSL3‐induced ferroptosis with EC50 values of 0.83 μM, 2.05 μM, 0.96 μM, 1.47 μM, and 1.19 μM, respectively.

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Section: Nmr Calculationsmentioning

confidence: 99%

Chemical Constituents of Ajuga Lupulina and their Anti‐Ferroptosis Activity

Teng,

Shi,

Cao

et al. 2024

Chemistry & Biodiversity

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Euphpepluone S, a new lathyrane diterpenoid with anti-inflammatory activity from Euphorbia peplus L.

Guan

Yang

Sun

et al. 2023

Phytochemistry Letters

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Tigliane-and daphnane-type diterpenoids from the buds of Daphne genkwa with their cytotoxic activities

Chen

Zhao

Dong

et al. 2022

Natural Product Research

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Two new tigliane-and daphnane-type diterpenoids, given the trivial names daphnegens A-B (1-2) were isolated from the buds of Daphne genkwa. Their structures were assigned on the basis of extensive spectroscopic. The absolute configurations of both compounds were determined by comparison of their calculated and experimental CD curves. In addition, compounds 1-2 were tested for their cytotoxic activities against MCF-7 and HepG-2 human cancer cell lines, and compound 2 showed remarkable cytotoxic activity against HepG-2 cell line with the IC 50 value of 11.5 μM.

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Six new tigliane diterpenoids with anti-inflammatory activity from Euphorbia kansuensis

Cited by 3 publications

References 24 publications

Chemical Constituents of Ajuga Lupulina and their Anti‐Ferroptosis Activity

Chemical Constituents of Ajuga Lupulina and their Anti‐Ferroptosis Activity

Euphpepluone S, a new lathyrane diterpenoid with anti-inflammatory activity from Euphorbia peplus L.

Tigliane-and daphnane-type diterpenoids from the buds of Daphne genkwa with their cytotoxic activities

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