Situation de la drepanocytose au Togo

Segbena, AY; Messie, A. K.; Vovor, A.; Gbadoe, AD; Assimadi, J. K.

doi:10.4314/jrsul.v7i1.47508

Cited by 4 publications

(6 citation statements)

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“…As shown by Segbena et al (2005) in Togo there is an incidence at birth of 1.17% of the homozygous form SS and the national average is 1.3% and there is an increase of HbS/HbC at the northern part of the country (Vovor et al, 2014).…”

Section: Introductionmentioning

confidence: 98%

Evaluation of the anti-sickling activity of <i>Newbouldia laevis</i> P. Beauv extracts

Dermane¹,

Kpegba²,

Metowogo³

et al. 2019

Int. J. Bio. Chem. Sci

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Sickle cell disease is a genetic disease very expanded all over the African block. In Togo like most African countries, it's one of major causes of morbidity and mortality. The available treatments are very ornamental and are most of the time remedy than cure. However, in our areas, the sicks use medicinal plants for treating themselves. It's in this scope that this study has been conducted in sight of assessing the anti-sickling activity of Newbouldia laevis extracts (leaves, roots and stem barks) based on Emmel test using 2% sodium metabisulphite. The extracts were also studied for its in vitro antioxidant activity using 2,2-diphenyl-1picrylhydrazyl (DPPH) and 2,2'-azobis (2-amidinopropane hydrochloride) (AAPH) methods. The results obtained show that the roots and the stem barks extracts have a comparable efficiency. These extracts enabled us to reduce the sickling rate respectively at 17% and 16% against 78% for the control that was incubated in the presence of 0.9% sodium chloride. The leaves extract led to hemolysis and hemolysing concentration was 5mg/ml. Light antioxidant activity in vitro was obtained for the two extracts. Our outcomes proved that in vitro, roots and stem barks of Newbouldia laevis extracts have an anti-sickling activity contrary to the hemolysing leaves extract.

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Section: Introductionmentioning

confidence: 98%

Evaluation of the anti-sickling activity of <i>Newbouldia laevis</i> P. Beauv extracts

Dermane¹,

Kpegba²,

Metowogo³

et al. 2019

Int. J. Bio. Chem. Sci

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“…In a study realized in 2002 in Togo on 5604 samples, the main abnormal hemoglobins were the S (AS trait 15.8 to 16.7%) and C (AC trait 12.1 to 15.8%) variants. SS sickle cell disease was observed in 1.2 to 2% of subjects and SC sickle disease in 4.2% (3). The national health development program for the years 2017 to 2022, prioritized the ght against non-communicable diseases including SCD in the health policy and control component (4).…”

Section: Introductionmentioning

confidence: 99%

Hemoglobin status in children attending paediatric clinics in Lomé, 2022.

Konu,

Lack,

Adama

et al. 2024

Preprint

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Aim: to estimate the prevalence of sickle cell disease among children and adolescents in the pediatric department of the Sylvanus Olympio University Hospital in 2022. Methods: in this cross-sectional study, all children and adolescents attending the study site were proposed to participate and included if: i) aged between 18 months and 19 years, ii) present in pediatric consultations or hospitalizations and iii) provided assent or parental informed consent. A 4-5 ml blood sample was collected for hemoglobin electrophoresis on a cellulose acetate plate at alkaline pH. Sickle cell disease was defined as having either SS, SC, SF or Sß hemoglobin phenotype. Results: A total of 317 children and adolescents aged 8 years (IQR: 4-12) in median were enrolled. Only in 7.3% of cases did both parents know their hemoglobin status. 68 children/adolescents had hemoglobin S (21.5%), 19 had sickle cell disease (6.0%). Approximately 15.6% of children and adolescents had sickle cell trait AS. Conclusion: This study revealed a high SCD prevalence in an a priori naïve children/adolescents’ population. We stress that policy makers should consider continued sensitization, genetic counseling and neonatal screening as prevention strategies in Togo.

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“… 2 In Togo, a country of the West African region with approximately 7.889 million people, SCD is the most common hemoglobin (Hb) abnormality. 3 The frequency of the HbS gene has been estimated at 16.1%, the prevalence of HbSS at 1.3%, and the prevalence of the double heterozygous forms (HbSC and HbS/β-thalassemia [βthal]) at 2.6%. Approximately 200,000 Togolese are estimated to have a major form of SCD (HbSS, HbSC, or HbS/βthal).…”

Section: Introductionmentioning

confidence: 99%

“…Approximately 200,000 Togolese are estimated to have a major form of SCD (HbSS, HbSC, or HbS/βthal). 3 …”

Section: Introductionmentioning

confidence: 99%

Systemic T Cell Subsets and Cytokines in Patients With Homozygous Sickle Cell Disease and Asymptomatic Urinary Tract Infections in Togo

Tchopba

Katawa

Padaro

et al. 2021

TOJ

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Background: In sickle cell disease (SCD), cytokine expression influences the pivotal pathways that contribute to disease pathogenesis. Additional infection could affect the immune profile of patients with SCD and increase disease mortality. The aim of this study was to investigate the cytokines and T helper cells profile in patients with asymptomatic urinary tract infection and homozygous SCD (HbSS). Methods: From July to September 2018, 22 HbSS subjects were recruited at Centre Hospitalier Universitaire Campus in Lomé, Togo, 12 of whom had urinary tract bacterial infections and 10 of whom were uninfected. Cytokines from plasma were measured by the enzyme-linked immunosorbent assay (ELISA) sandwich method, and immune cell profiles were performed by flow cytometry. The immunogenicity of bacteria-derived antigens isolated from the urine of HbSS subjects with asymptomatic urinary tract infections was studied in a cell culture system, and the induction of the cytokines was measured. Results: The mean age of HbSS subjects with urinary tract infections was 20.33 ± 3.58 years, and the male/female ratio was 0.09 (1:11). HbSS subjects with asymptomatic urinary tract infections had elevated plasma levels of interferon gamma (IFN-γ) and interleukin (IL)-10. CD4 + Tbet + IFN-γ + and CD4 + FoxP3 + IL-10 + T cell populations were decreased in HbSS subjects with asymptomatic urinary tract infections. Bacterial antigens from HbSS subjects induced the production of IL-10 but not IFN-γ in uninfected volunteer donors (HbAA). Conclusion: Our study demonstrated that patients with SCD and asymptomatic urinary tract infections had elevated IFN-γ and IL-10 levels. This chronic inflammatory condition could be a risk for this group of patients in terms of vaso-occlusive crisis. Systematic cytobacteriologic examination of the urine of HbSS subjects would be of interest.

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Situation de la drepanocytose au Togo

Cited by 4 publications

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Evaluation of the anti-sickling activity of <i>Newbouldia laevis</i> P. Beauv extracts

Evaluation of the anti-sickling activity of <i>Newbouldia laevis</i> P. Beauv extracts

Hemoglobin status in children attending paediatric clinics in Lomé, 2022.

Systemic T Cell Subsets and Cytokines in Patients With Homozygous Sickle Cell Disease and Asymptomatic Urinary Tract Infections in Togo

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