Site-Specific Phosphorylation of Ikaros Induced by Low-Dose Ionizing Radiation Regulates Cell Cycle Progression of B Lymphoblast Through CK2 and AKT Activation

Transcriptome analysis of low-dose ionizing radiation-impacted genes in CD4+ T-cells undergoing activation and regulation of their expression of select cytokines

“…In a previous report (Cho et al 2016), it was noted that LDIR could regulate B-cell lympho-proliferation in an Ikaros-dependent manner. In particular, LDIR <100 mGy specifically induced Ikaros phosphorylation to regulate cell cycle progression.…”

Low-dose radiotherapy effects the progression of anti-tumor response

“…Research on the effects of low-dose radiation on humoral immunity is limited; however, it is hypothesized that low-dose radiation may act as a unique weak antigen to stimulate the repeated polyclonal activation of B cells, thereby inducing immunoglobulin formation and enhancing humoral immune function [55] . Studies have indicated that LDRT might increase Ikaros gene protein phosphorylation by activating casein kinase 2 and Akt, consequently promoting B lymphocyte proliferation, stimulating specific cytokine secretion, and activating related cellular pathways to eliminate tumor cells [ 56 , 57 ]. EOM et al.…”

Hormetic Response to Low-Dose Radiation: Focus on the Immune System and Its Clinical Implications

“…LDR could enhance B lymphoblast proliferation by elevation of cyclin E and cyclin-dependent kinase 2 (CDK2), as well as elevation of the phosphorylation level of Ikaros protein, a member of the zinc finger-containing transcription factor family [59]. LDR can also modulate B cell differentiation through the activation of NF-κB and the induction of cell differentiation molecule CD23 expression [60].…”