Low-dose radiotherapy effects the progression of anti-tumor response

Gao, Lei; Zhang, Anqi

doi:10.1016/j.tranon.2023.101710

Cited by 4 publications

(2 citation statements)

References 86 publications

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“…The findings of various studies have demonstrated that LDRT possesses the ability to reprogram the TME and facilitate extensive immune cell infiltration ( 18 , 29 ). We evaluated the effect of whole-lung LDRT on the development of TLSs in mouse lung cancer.…”

Section: Resultsmentioning

confidence: 99%

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Low-dose radiotherapy promotes the formation of tertiary lymphoid structures in lung adenocarcinoma

Wang,

Huang,

Qian

et al. 2024

Front. Immunol.

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PurposeA tertiary lymphoid structure (TLS) refers to an organized infiltration of immune cells that is linked to a positive prognosis and improved response to immunotherapy. However, methods that promote TLS formation are limited and challenging to implement in clinical settings. In this study, we aimed to promote the formation and maturation of TLSs in lung adenocarcinoma (LUAD) by combining low-dose radiotherapy (LDRT) with immunotherapy.MethodsTissue sections from 198 patients who had undergone surgery were examined. Risk factors for patient survival were assessed, and the relationship between TLSs and five-year survival was analyzed. The Kras-LSL-G12D spontaneous lung cancer mouse model was used to screen the optimal irradiation dose (0/1/2 Gy whole lung irradiation) for promoting TLS formation. LDRT combined with anti-PD-1 was used to promote the formation and maturation of TLSs.ResultsTLS+, TLSHigh, TLS+GC+ and CD8High within TLS+ were associated with a favorable prognosis. LDRT increased the formation of early TLSs in the Kras-LSL-G12D lung cancer mouse model. In addition, LDRT combined with anti-PD-1 treatment can significantly improve the maturity of TLSs in mouse LUAD, resulting in greater antitumor effects. This antitumor effect was strongly associated with the number of CD8+ T cells within the TLSs.ConclusionWe successfully applied LDRT combined with PD-1 inhibitor therapy for the first time, which increased both the quantity and maturity of TLSs in lung cancer. This approach achieved a promising antitumor effect.

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Section: Resultsmentioning

confidence: 99%

“…However, these methods are challenging to implement in a clinical setting. In recent years, low-dose radiotherapy (LDRT) with doses ranging up to 2 Gy per segment has emerged as a promising approach to enhancing antitumor immunity ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

Low-dose radiotherapy promotes the formation of tertiary lymphoid structures in lung adenocarcinoma

Wang,

Huang,

Qian

et al. 2024

Front. Immunol.

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Radiotherapy of high-grade gliomas: dealing with a stalemate

Frosina

2023

Critical Reviews in Oncology/Hematology

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Frequent CT Scan Radiation Activates Interferon Responses and Antitumor T-Cell Immunity

Dong,

Wang,

et al. 2024

Preprint

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Objective: This study aims to elucidate the impact of repeated whole-body computed tomography (CT) scans on systemic immunity, the tumor immune microenvironment, and tumor control. This inquiry was prompted by clinical observations indicating a decrease in the levels of IFN-β and IFN-γ in patients' blood following whole-body CT scans. Methods: A Lewis lung carcinoma (LLC) xenograft mouse model was established and divided into two groups: a control group and a group subjected to multiple whole-body CT scanning radiation (WBCTSs). The study monitored tumor growth trends across both groups and employed a comprehensive set of analytical techniques—including enzyme-linked immunosorbent assay (ELISA), flow cytometry analysis, immunohistochemistry, RNA sequencing, and single-cell sequencing—to assess differences in cytokine profiles (IFN-β and IFN-γ), proportions of key immune cells, and gene expression variations between the groups. Results: Repeated CT scan radiation demonstrated a trend toward delaying tumor progression. In tumors exposed to multiple CT scans, there was an observed increase in the proportion of CD8+ T cells and an upregulation of genes associated with IFNγ in CD8+ T cells and IFN-β in macrophages. Concurrently, interferon levels within the tumor tissue also showed an increase.Conversely, the radiation from multiple whole-body CT scans resulted in a decreased proportion of CD8+ T cells in the blood and spleen, accompanied by a downregulation of genes associated with IFNγ in CD8+ T cells and IFN-β in macrophages, as well as a reduction in serum interferon levels. Conclusion: Our results suggest that repeated whole-body CT scanning radiation induces systemic immunosuppression as well as immune activation in tumor tissue. Multiple CT scans do not exacerbate cancer, but rather may act as a barrier to cancer progression.

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Low-dose radiotherapy effects the progression of anti-tumor response

Cited by 4 publications

References 86 publications

Low-dose radiotherapy promotes the formation of tertiary lymphoid structures in lung adenocarcinoma

Low-dose radiotherapy promotes the formation of tertiary lymphoid structures in lung adenocarcinoma

Radiotherapy of high-grade gliomas: dealing with a stalemate

Frequent CT Scan Radiation Activates Interferon Responses and Antitumor T-Cell Immunity

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