Site predilection of extrapulmonary tuberculosis: study from a tertiary care centre

Mavila, Rajani; Kottarath, Manoj D.; Nair, Smitha; Thaha, Milan Malik

doi:10.18203/2320-6012.ijrms20151197

Cited by 8 publications

(8 citation statements)

References 7 publications

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“…Similar observations were made in the study by Ramaprakash et al, who documented 51.52% males and Mavila R et al, who reported 112 (59.9%) male as sufferers of extra-pulmonary TB. 16,17 In present series, lymph node involvement was the most common site (52.9%) followed by pleura (25.9%). Similar results were reported by Ilgazli et al, who witnessed 56.3% lymph node involvement followed by 31.1% pleural involvement out of 636 cases with EPTB.…”

Section: Discussionmentioning

confidence: 55%

Pattern of extra pulmonary tuberculosis among urban population with special reference to CBNAAT as a diagnostic tool: a retrospective study at a tertiary care hospital of Odisha, India

Rao¹,

Thakur

Subhankar

et al. 2018

Int J Res Med Sci

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Background: Diagnosis of Extra-pulmonary TB (EPTB) is a challenge. Authors wanted to assess the sites of extra-pulmonary involvement during 2013-2017 in a tertiary care hospital cum medical college. Authors also wanted to evaluate the role of Cartridge Based Nucleic Acid Amplification Test (CBNAAT) in diagnosis of EPTB and compare its efficacy with AFB Culture.Methods: Total 470 EPTB cases diagnosed between 2013 and 2017 from 840 TB treatment records maintained in designated microscopy centre. Specific samples from appropriate sites were taken up for smear for AFB, CBNAAT and AFB culture.Results: There was incremental detection and registration in both TB and EPTB cases from 96 and 50 cases in 2013 to 246 and 150 cases in 2017 respectively. Among the total 470 EPTB cases in 2013-2017 (55.9%), lymph node followed by pleura and abdomen were the organs having maximum involvement. Bone involvement was more witnessed in adult male than children (p <0.05). There was male preponderance. CBNAAT results were 100 % sensitive and 87.5% specific. Lymph node samples and pus elsewhere in the body had much better diagnostic yield than serous effusions.Conclusions: Awareness and availability of diagnostic services in tertiary care institutions has lead to increased reporting of EPTB under RNTCP services. CBNAAT can be also be utilized as a point of care testing for lymph node aspirate and pus specimen.

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Section: Discussionmentioning

confidence: 55%

Pattern of extra pulmonary tuberculosis among urban population with special reference to CBNAAT as a diagnostic tool: a retrospective study at a tertiary care hospital of Odisha, India

Rao¹,

Thakur

Subhankar

et al. 2018

Int J Res Med Sci

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“…12 Similar observations were found by Mavila R et al where extrapulmonary manifestation were lymph node (29.4%), gastrointestinal (24%), pleura (23.5%), skeletal (7.5%) and others. 13 The sputum smear results of the study subjects at DOTS clinic, KPCMCH, reflected that the results were negative in 10% patients, scanty in 3.7%, '+' in 1.2%, '++' in 7.5% and '+++' in 17.5% patients. A study conducted at Midnapur district, West Bengal, by Dey D et al showed that sputum grade at diagnosis were scanty (6.9%), negative (19.3%), '+' (44.4%), '++' (12.1%) and '+++' (17.4%).…”

Section: Resultsmentioning

confidence: 91%

A study on clinical profile of indoor patients receiving anti-tuberculosis treatment at KPC Medical College and Hospital, Kolkata, India

Karir

Biswas

Mandal

et al. 2016

Int J Community Med Public Health

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“…25 Similar observations were made in the study by Ramaprakash et al, who documented 51.52% males and Mavila R et al, who reported 112 (59.9%) male as sufferers of extra-pulmonary TB. 26,27 CBNAAT results of EPTB specimen revealed higher diagnostic yield from lymph node aspirate and pus compared to no detection from pleural fluid, CSF and peritoneal fluids. This could be explained by the hypersensitivity phenomenon; because few organisms are present in the pleural space, this is a Cell Mediated Immunity phenomenon.…”

Section: Resultsmentioning

confidence: 92%

Pattern of tuberculosis among tribal population of Central India with special reference to cartridge based nucleic acid amplification test as diagnostic tool: a descriptive study at tertiary care hospital

2019

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Background: Tuberculosis (TB) kills close to half a million Indians every year. Lack of reliable rapid diagnostic techniques for TB hampers timely diagnosis and leads to continued disease transmission, causing significant morbidity and mortality. The potential of newly recommended CBNAAT in TB and MDR-TB detection has been underutilized in our area due to lack of awareness regarding the same. Hence we utilized this rapid, logistically simplified test to study the pattern of tuberculosis among tribal population of Central India.Methods: Descriptive study of suspected TB patients in tertiary care centre from March 2016 to March 2019. Appropriate specimens from suspected TB patients were collected and subjected to CBNAAT and AFB smear to study the pattern of TB and Rifampicin- Resistant(RR) TB in our area.Results: CBNAAT detected overall 27% MTB cases; 27.72 % Pulmonary-TB cases as against smear positivity rate of 20.73% whereas 12.74% Extra-pulmonary-TB (EPTB) cases as against smear positivity rate of 1.59%.Overall 94.91% were RiF Sensitive( RS-TB) and 4.58% were RR-TB. Of the 57 (4.16%) HIV-TB coinfected cases; 96.49% were RS-TB and 5.26% were RR-TB. Co-infected patients have high incidence of EPTB(21.05%) involvement with RR-TB 3.50%. Among EPTB cases; lymph node aspirate and pus provided highest CBNAAT positive cases and almost 90.62% EPTB specimens were RS-TB .Conclusions: Availability of new diagnostic services has increased early identification of TB and RR-TB. Awareness among physicians regarding diagnostic utility of CBNAAT should be further increased as early identification of possible MDR cases is key to reducing community transmission and treatment initiation, particularly in high-burden, resource-limited settings.

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Site predilection of extrapulmonary tuberculosis: study from a tertiary care centre

Cited by 8 publications

References 7 publications

Pattern of extra pulmonary tuberculosis among urban population with special reference to CBNAAT as a diagnostic tool: a retrospective study at a tertiary care hospital of Odisha, India

Pattern of extra pulmonary tuberculosis among urban population with special reference to CBNAAT as a diagnostic tool: a retrospective study at a tertiary care hospital of Odisha, India

A study on clinical profile of indoor patients receiving anti-tuberculosis treatment at KPC Medical College and Hospital, Kolkata, India

Pattern of tuberculosis among tribal population of Central India with special reference to cartridge based nucleic acid amplification test as diagnostic tool: a descriptive study at tertiary care hospital

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