Site of Action of Aflatoxin on Human Liver Cells in Culture

Zuckerman, A. J.; Rees, K. R.; Inman, D. R.; Petts, Valerie

doi:10.1038/214814b0

Cited by 29 publications

(5 citation statements)

References 4 publications

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“…Nesbitt et al (1962) and Asao et al (1963) reported that the LD50 of G1 was three times that of B1 to 1-day-old ducklings. Zuckerman, Rees, Inman & Petts (1967) showed that the necrotizing dose of G1 was three times that of B1 in human-liver cells grown on culture. Certain of the aflatoxins are carcinogenic and there is a variation in their carcinogenicity.…”

Section: Discussionmentioning

confidence: 99%

The effect of the aflatoxins B1, G1, and G2 on protein and nucleic acid synthesis in rat liver

Clifford¹,

Rees²,

Stevens³

1967

Biochemical Journal

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A comparison has been made of the difference spectra obtained by causing various aflatoxins (B(1), G(1) and G(2)) to interact with calf-thymus DNA. The effect of these toxins on RNA and protein synthesis by rat-liver slices has been measured. The extent of their inhibitory action on the synthetic reactions was proportional to the degree of spectral shift obtained with their interaction with DNA. It is proposed that their toxicity depends on this interaction. It was demonstrated that the RNA polymerase of nucleoli isolated from the livers of aflatoxin B(1)-poisoned rats was inhibited. This finding is in agreement with the proposed mechanism for the hepatotoxic action of aflatoxin.

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Section: Discussionmentioning

confidence: 99%

The effect of the aflatoxins B1, G1, and G2 on protein and nucleic acid synthesis in rat liver

Clifford¹,

Rees²,

Stevens³

1967

Biochemical Journal

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“…This enzyme was identified as versicolorin B synthase and was studied intensively by Townsend’s laboratory [114,133,134,135,136]. The gene was cloned and named vbs [114,134,136]. The expected cyclase activity was demonstrated by the expressed recombinant protein of the vbs gene [134,135].…”

Section: Genetics and Molecular Biology Of Aflatoxin Biosynthesismentioning

confidence: 99%

Current Understanding on Aflatoxin Biosynthesis and Future Perspective in Reducing Aflatoxin Contamination

2012

Toxins

283

270

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Traditional molecular techniques have been used in research in discovering the genes and enzymes that are involved in aflatoxin formation and genetic regulation. We cloned most, if not all, of the aflatoxin pathway genes. A consensus gene cluster for aflatoxin biosynthesis was discovered in 2005. The factors that affect aflatoxin formation have been studied. In this report, the author summarized the current status of research progress and future possibilities that may be used for solving aflatoxin contamination.

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“…The evidence to date indicates that aflatoxins interfere with the transcription of nuclear DNA by RNA and DNA polymerases, either by modifying the template activity of DNA or by directly interacting with the polymerases (Clifford & Rees, 1966;Clifford, Rees and Stevens, 1967;Zuckerman, Rees, Inman & Petts, 1967).…”

Section: Discussionmentioning

confidence: 99%

Aflatoxin-induced tumors in mice

Louria¹,

Finkel²,

Smith³

et al. 1974

Med. Mycology

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Mice were given a mixture of aflatoxins B and G subcutaneously ( 100 ~zg/day), by force feeding ( 100 ~g/day) or by aerosol ( 1 mg/ml) for up to one year. Those given the aflatoxins subcutaneously developed local sarcomas in dose-related fashion. Those given aflatoxins by any route showed an incidence of lymphatic leukaemia significantly greater than age-matched control mice.Aflatoxins, derived from Aspergilli or occasionally from strains of Peniciltium can

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Site of Action of Aflatoxin on Human Liver Cells in Culture

Cited by 29 publications

References 4 publications

The effect of the aflatoxins B1, G1, and G2 on protein and nucleic acid synthesis in rat liver

The effect of the aflatoxins B1, G1, and G2 on protein and nucleic acid synthesis in rat liver

Current Understanding on Aflatoxin Biosynthesis and Future Perspective in Reducing Aflatoxin Contamination

Aflatoxin-induced tumors in mice

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