“…Thus, inhibition of RNA synthesis is accompanied by nucleolar segregation (Svoboda and Higginson, 1968), and inhibition of protein synthesis by the detachment of ribosomes from the rough-surfaced endoplasmic reticulum and the proliferation of smooth membranes (Butler, 1966;Clifford, Rees and Stevens, 1967;Svoboda and Higginson, 1968;Harley, Rees and Cohen, 1969). Apparent membrane degranulation is often seen as a response to drug challenge and accompanies the induction of enzymes associated with nascent smooth membrane and is also associated with drug detoxication (Arcos, Conney and Buu-Hoi, 1961;Orrenius and Ericsson, 1966;Conney, 1967).…”